Sentences with phrase «of tumor heterogeneity»
This is particularly true for immunotherapy, in which characterization of tumor heterogeneity is essential for choosing the most effective therapy.
sciencemag.org
Presently, the development of more effective therapies is hampered by the large degree of tumor heterogeneity, both between different patients and in a single tumor.
His area of interest is exploring the effects of tumor heterogeneity on relapse and resistance to therapies in sarcomas.
The Ignatius laboratory is interested in understanding the effects of tumor heterogeneity on relapse and resistance to therapies in Rhabdomyosarcoma and other sarcomas.
Interest in liquid biopsy has escalated in recent years due to the minimally invasive sampling method, potential to overcome the challenges of tumor heterogeneity, and the potential for longitudinal monitoring of tumor burden through serial sampling.
The traditional model of tumor heterogeneity suggests that sequential mutations over time lead to the emergence of fitter cells that continue to grow and take over the tumor — called the clonal selection model.
These studies will lead to in - depth investigations of tumor heterogeneity and the dynamic regulation of genes that define subpopulations with specialized biologic functions.
[16] Second, we investigated the degree of tumor heterogeneity, which has been shown to be quite significant in primary kidney cancer [33].