Sentences with phrase «of tumor invasion»

CT scan of the bulla is the most diagnostic test to see the internal structure of the bulla and extent of tumor invasion

In one study, median survival time was 118 days for dogs with evidence of tumor invasion of other local organs compared with 218 days for dogs with no evidence of invasion beyond the urinary bladder.

Not exact matches

According to ICES Director J. Tinsley Oden, mathematical models of the invasion and growth of tumors in living tissue have been «smoldering in the literature for a decade,» and in the last few years, significant advances have been made.

Published in the February 27 issue of Cell, the study found that tumor cells that reach the brain — and successfully grow into new tumors — hug capillaries and express specific proteins that overcome the brain's natural defense against metastatic invasion.

In recent years, atypical protein kinase C signaling has been found in the tissue invasion and metastasis of multiple tumors.

Instead of displaying the full complement of incriminating proteins on the tumor cell's surface, the dog cancer displays just a few, obfuscating the invasion underway.

For their own part, Lowe and his team will next examine the consequences of Apc reactivation in tumors that progress beyond local invasion to produce distant metastases.

A neuro - oncology research team at Dartmouth's Norris Cotton Cancer Center, led by the Director Mark A. Israel, MD with first author Gilbert J. Rahme, PhD, recently identified the transcription factor Id4 as a suppressor of tumor cell invasion in glioblastoma.

«By understanding how stress accelerates invasion in aggressive breast tumor cells, this work will inform future studies into whether beta - blockers could be a useful adjuvant therapy in the treatment of some aggressive breast cancers.»

«This finding suggests a novel therapeutic target to decrease invasion of tumor cells in patients and may also provide a novel biomarker that could help predict survival of patients with glioblastoma,» explained Israel.

Their results demonstrate that specific rhoptry and dense granule effector proteins that T. gondii secretes before and after host cell invasion, respectively, control the development of an effective host antitumor response, and increase the survival of mice with ovarian tumors.

It is likely that a similar mechanism operates during cancer invasion, which suggests a promising alternative in which cancer treatments might work in the future, if therapies can be targeted to limit the tissue fluidity of tumors.

So a drug that blocks DDR2 from binding with collagen won't destroy the tumor, but it could inhibit the invasion of these tumors into surrounding tissue and reduce metastasis.

In the laboratory they showed how morphine can increase proliferation, migration and invasion of tumor cells.

Under the microscope, it is possible to identify invasion of the tumor into the lymph and blood vessels, this being the tumor behaviour responsible for the formation of metastases, so that it can be used as a prognostic factor.

However, when these myeloid cells migrate to tumor sites, they can differentiate to tumor associated macrophages (TAMs), which can in turn stimulate the formation of blood vessels in tumors and promote enhanced tumor cell invasion and motility.

In addition, Sox9 acts also as key orchestrator of the extracellular matrix remodeling, cell adhesion and cytoskeleton dynamics required for tumor invasion.

«BMI1 plays a substantial role in many solid tumors, including one of the most aggressive models of lung cancer, and its expression is linked with tumor growth, invasion, metastasis, prognosis and recurrence,» Levantini said.

Staging is based on tumor thickness (Breslow's measurement) and histologic level of invasion (Clark level).

Thus, in a panel of breast cancer samples, we identified tumor cells that did not form part of the bulk tumor mass, but instead were interspersed within the adjacent stroma — as if forming the forefront of cancer cell invasion.

Collectively, our results indicated that RASSF1 acts to restrict EMT and invasion by indirectly controlling YAP nuclear shuttling and activation through a RhoB - regulated cytoskeletal remodeling process, with potential implications to delay the progression of RASSF1 - hypermethylated lung tumors.

Hence, BH3 mimetics might represent an attractive approach of eliminating resistant subpopulations of cancer cells, thereby targeting both tumor cell invasion and cancer relapse.

We are focusing on a few key molecular pathways including; 1) Polycomb - mediated epigenetic gene silencing in the tumor initiation, maintenance, and invasion, 2) c - Met (receptor tyrosine kinase) signal transduction pathways in stemness and migration of these tumor cells, 3) Novel mitogenic signaling pathways that are specific to GSCs, and 4) Identification of radio - and chemo - sensitizing pathway to maximize therapeutic efficacy.

University of Hawai'i Cancer Center researchers have identified an essential driver of tumor cell invasion in glioblastoma, the most aggressive form of brain cancer that can occur at any age.

Biocellion is being used to model a variety of biological system behaviors, such as biofilm formation and wrinkling, microbial growth dynamics in complex soil structure, brain tumor growth and invasion, formation of complex bacterial colonies, and changes in blood vessels and skin cells.

HIF - 1 plays important roles in critical aspects of cancer biology, including tumor angiogenesis, regulation of glucose and energy metabolism, invasion, and metastasis.

Research fields include translational research, invasion, metastasis, disseminated tumor cells, transcription, tumor - associated proteolysis, targeted therapy, micro-RNA, molecular staging of cancer.

Through its various targets, MMP1 promotes not only tumor invasion but also breast cancer colonization to bone by mechanisms that include the release of membrane - bound EGF - like growth factors from tumor cells, leading to activation of EGF receptor signaling and suppression of OPG expression in osteoblasts, which in turn promotes the differentiation and activation of osteoclasts required for bone destruction and enhanced tumor growth in the bone microenvironment (32).

Finally, in collaboration with physicists from the Institute Curie, we are also investigating if, in addition to cellular and biochemical tumor microenvironment, mechanical pressure imposed by stroma can stimulate invasion of cancer cells.

Our results highlight FN assembly and integrin - αvβ3 expression as new hallmarks of CAFs that promote tumor invasion.

We propose a tension - based model to explain the collagen organization and the onset of invasion by forces originating from the tumor.

Metastasis begins with the invasion of tumor cells into the stroma and migration toward the blood stream.

The tumor microenvironment, and in particular stroma organization, influences the mode and dynamics of invasion.

This confirmed that the gene regulatory switch is highly specific to one cell type, monocytes and that tumor cell invasion in the absence of this population had nothing to do with deregulated macrophage activity.

They also show how this interaction can increase proliferation, migration and invasion of tumor cells, three hallmarks of cancer growth and spread.

The central focus of my future work is to elucidate the mechanisms by which tumorigenesis results in the conversion of TGFβ from a suppressor of tumor formation to a promoter of tumor growth, invasion, and metastasis.

The idea was to identify genes that were metastasis determinants by correlating gene expression with some kind of invasion assay that measured tumor progression.

Tumors thrive in a low oxygenated environment and this condition known as hypoxia promotes the invasion of cancer and its growth (1).

«consumption of abundant alkaline - forming foods can result in improvement in bone mineral density (BMD) and muscle mass, protection from chronic illnesses, reduced tumor - cell invasion and metastasis, and effective excretion of toxins from the body.

He goes on to say, «One theory is that when patients ingest our Turkey Tail mycelium, the immune system's increased populations of NK cells and their associated CD8 glycoproteins are better able to discover and bind to receptor sites on the stroma of tumors, thus allowing NK invasion.

They help block the ability of cancer cells to produce the tumor invasion enzyme in the first place, in both human colon cancer cells, and human breast cancer.

«Tumor growth, invasion, and metastasis are multistep processes» that includes not just cell proliferation, but invasion through the surrounding tissue, and «migration through basement membranes» to reach the bloodstream before the tumor can establish «new proliferating colonies» of cancer cTumor growth, invasion, and metastasis are multistep processes» that includes not just cell proliferation, but invasion through the surrounding tissue, and «migration through basement membranes» to reach the bloodstream before the tumor can establish «new proliferating colonies» of cancer ctumor can establish «new proliferating colonies» of cancer cells.

The scan revealed large adrenal tumors present on both sides without significant evidence of invasion into the vasculature or surrounding structures.

Stage 2 and Stage 3 tumors display more signs of invasion, have unclean margins, and maybe multiple tumors.

The criterion of invasion, or how much the tumor tissue invades or affects the surrounding tissue, differentiates benign from malignant tumors.

There is often evidence of lymphatic invasion on Perianal tumors.

The malignant tumors can spread quickly to other areas in your pet's body while the benign can't spread, but it can cause significant damage due to its growth and invasion of surrounding tissues.

or staggering, forgetting The symptoms associate with brain tumors vary widely but are generally caused by compressing of or invasion into the brain.