Audi spent a couple of days in the hospital on supportive care after starting chemotherapy to help avoid side effects
of tumor lysis, a syndrome that can occur and make the patient very ill when a large volume of tumor cells are rapidly killed by chemotherapy.
All of our patients had some sort
of tumor lysis syndrome.
Not exact matches
Recently, we showed that bortezomib treatment in mice bearing breast and kidney
tumors provided host survival benefit by amplifying
tumor cell caspase8 activation, CD8T cell effector molecules via increased NotchNFkB crosstalk and Fas ligandmediated
lysis of tumor cells.
Tumors can suppress CD4 + T cell activity and CTL
tumor lysis directly through secretion
of immunosuppressive factors including TGF - β1 but also PGE - 2, and IL - 10.
Instead
of targeting specific
tumor antigens, this approach relies on endogenous antigens (including neoantigens) released during
tumor lysis by treatments such as chemotherapy or local radiation.
When bone
lysis was present, malignant
tumors were diagnosed in 83 %
of patients however 17 %
of patients with radiographic evidence
of bone
lysis were diagnosed with a benign process.