Sentences with phrase «of tumor metabolism»

«These results highlight that 14 -3-3 sigma is an important regulator of tumor metabolism, and loss of 14 -3-3 sigma expression is critical for cancer metabolic reprogramming.»

Not exact matches

This study of 37 patients (24 men and 13 women, ages 51 to 80) who have never been treated with chemotherapy found direct correlation of the amount of cfDNA with tumor metabolism (based on PET - derived parameters), but not with metabolic tumor volume.

In a study presented in the featured clinical investigation article of the November issue of The Journal of Nuclear Medicine, they used 18F - fluorodeoxyglucose (FDG) PET / CT imaging to show that the amount of cell - free tumor DNA circulating in the bloodstream correlates with tumor metabolism (linked to cancer aggressiveness), not tumor burden (amount of cancer in the body).

Women who have high levels of both testosterone and estrogen in midlife may face a greater risk of developing benign tumors on the uterus called uterine fibroids than women with low levels of the hormones, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism.

«These tumors are genetically very complex, and we demonstrated this by showing just the sheer volume of copy number changes, and that there are multiple clones in a single metastases tumor, and changes in metabolism that reflects the tumor's ability to adapt.»

Aware that cancers rewire their metabolism in ways that could change the epigenome and that distant metastases in pancreatic cancer naturally spread to organs fed by a sugar - rich blood supply, the researchers wondered if the tumor cells had altered the way they use the basic form of sugar, glucose.

«Conversely, the necrotic part of the tumor is driven by a distinct set of glioma stem cells utilizing the BIM1 pathway and are characterized by a mesenchymal, inflammatory cell type dependent on glucose metabolism in the absence of oxygen.

«Our original hypothesis was that cancer cells were modifying their metabolism based on communications they were receiving from cells in the microenvironment near the tumor,» said Nagrath, assistant professor of chemical and biomolecular engineering at Rice and co-author of a new study describing the research in the open - access journal eLife.

Even before a successfully treated tumor starts to shrink, its metabolism and thus the pH value of the surrounding area could change.

Anna Huttenlocher, University of Wisconsin, USA Neutrophils in the Tumor Microenvironment Neutrophils, Wounds, and Cancer Progression Stefan Kaufmann, Max Planck Institute, Germany Pathology and immune reactivity: understanding multidimensionality in pulmonary tuberculosis Constitutive BAK activation as a determinant of drug sensitivity in malignant lymphohematopoietic cells Kathryn Moore, New York University, USA MicroRNA -33-dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis Lalita Ramakrishnan, University of Cambridge, UK Myeloid Growth Factors Promote Resistance to Mycobacterial Infection by Curtailing Granuloma Necrosis through Macrophage Replenishment Beth Stevens, Harvard University, USA Microglia: Dynamic Mediators of Synapse Development and Plasticity Do glia drive synaptic and cognitive impairment in disease?

One hallmark of cancer is the accelerated metabolism, high energy requirements, and increased glucose uptake by the tumor cells, the latter being the first and rate - limiting step for glucose metabolism [2,3].

The growing evidence that cancer and metabolism are connected, emerging from a number of laboratories around the world over the past 10 years, has further fueled these hopes, though scientists are still working to identify what tumors might be most responsive and which drugs most useful.

LKB1, originally identified as a tumor suppressor protein, is currently thought as a critical regulator of cellular metabolism and growth by controlling the activity of AMP - activated protein kinase (AMPK) and also 12 other kinases that are closely related to AMPK.

Yet its contribution to tumor cell proliferation only increases the evidence that changes in metabolism are a cause of cancer and not just a consequence, according to Leif Ellisen, a cancer genetics researcher and oncologist who directs the MGH Translational Research Laboratory.

Results published by the Altieri laboratory demonstrated that these molecules accumulate in mitochondria of tumor cells, where they physically interact with components of the organelle permeability transition as well as with a number of regulators of bioenergetics, including the control of protein production, lipid metabolism and ATP generation.

HIF - 1 plays important roles in critical aspects of cancer biology, including tumor angiogenesis, regulation of glucose and energy metabolism, invasion, and metastasis.

«Maybe the normal versions of oncogenes and tumor suppressors originally evolved to regulate metabolism, and their mutations alter metabolism in ways that inevitably become oncogenic,» says Thompson.

«The Metabolic Profile of Tumors Depends on Both the Responsible Genetic Lesion and Tissue Type,» by Mariia O. Yuneva et al., Cell Metabolism, Feb. 8, 2012.

We have previously termed this new paradigm «The Autophagic Tumor Stroma Model of Cancer Metabolism», or the «Reverse Warburg Effect».

Using an RNA interference screen, Swanton and his colleagues identified a set of genes involved in the regulation of mitotic arrest and in the metabolism of ceramides, lipid molecules abundant in cell membranes that influence whether tumors are sensitive to certain chemotherapy agents.

Dr. Altieri also leads a research program that studies how tumor cells evade programmed cell death and the role of mitochondria, power plant of the cells, in tumor metabolism.

Autophagy sustains mitochondrial glutamine metabolism and growth of BrafV600E - driven lung tumors.

In 1931 Otto Heinrich Warburg was awarded the Nobel Prize in Physiology for his study on the metabolism of tumors and the respiration of cells, particularly cancer cells.

They are usually full of hormones and may cause tumors and metabolism disorders.

Tumor - bearing mice fed diets high in MCTs were found to have reduced levels of the enzyme fatty acid synthase and also reduced acetyl CoA, similar to tumor free mice, suggesting cancer cell metabolism was restored back to that of normal celTumor - bearing mice fed diets high in MCTs were found to have reduced levels of the enzyme fatty acid synthase and also reduced acetyl CoA, similar to tumor free mice, suggesting cancer cell metabolism was restored back to that of normal celtumor free mice, suggesting cancer cell metabolism was restored back to that of normal cells.94

My objective was to review relevant intervention studies on the effects of intermittent fasting on energy balance, cardiovascular risk factors, glucose metabolism, neurodegenerative pathology, tumor physiology and life span.

It has been hypothesized that the reported beneficial health effects from caloric restriction on excess body weight, cardiovascular risk factors, glucose metabolism, tumor physiology, neurodegenerative pathology and life span can be mimicked by alternating periods of short term fasting with periods of refeeding, without deliberately altering the total caloric intake.

PubMed between 1973 and 2011 was searched by use of relevant MeSH terms related to the effects of intermittent fasting on excess body weight, energy balance, aging physiology, cardiovascular risk factors, glucose metabolism, tumor physiology and neurodegenerative pathology.

Inborn errors of tryptophan metabolism exist where a tumor (carcinoid) makes excess serotonin.

They evaluated graviola extract and found that it contains compounds that play a role in regulating the metabolism, survival and growth of cancer cells, shrinking tumors and reducing cancerous cells» ability to grow and spread.

Nebeling LC, Miraldi F, Shurin SB, Lerner E. Effects of a ketogenic diet on tumor metabolism and nutritional status in pediatric oncology patients: Two case reports.

Because cancer cell metabolism relies upon glucose, minimizing a tumor's access to sugar as a means to manage or even limit cancerous cell growth has been the subject of several recent cancer therapy studies.

The Metabolism of Tumors, Arnold Constable, London.

This tumor produces excess amounts of thyroid hormone, which circulates through be bloodstream and affects the metabolism of many internal organs.

In cats, brain inflammations (encephalitis), as yet unexplained degenerative changes in the cat's hippocampal portion of the brain (ref1, ref2), exposure to toxic substances, flea and tick control products, traumatic brain injuries, abnormal body metabolism, brain tumors and FIP account for most of the rest.