Sentences with phrase «of tumor metastasis»

Takeda K, Hayakawa Y, Smyth MJ, Kayagaki N, Yamaguchi N, Kakuta S, Iwakura Y, Yagita H, Okumura K. Involvement of tumor necrosis factor - related apoptosis - inducing ligand in surveillance of tumor metastasis by liver NK cells.

Despite this clinical importance, the exact pathologic process of tumor metastasis is as yet poorly understood, and deciphering the exact molecular mechanism of this process is of paramount importance to identify specific therapeutic targets for this devastating disease.

The researchers also report that radiation sensitivity may be dependent on the anatomic location of the tumor metastasis.

Not exact matches

According to Irving Weissman of the Stanford University School of Medicine in Palo Alto, California: «We showed that even after the tumor has taken hold, the antibody can either cure the tumor or slow its growth and prevent metastasis.»

After adjusting for age, tumor location, and stage, researchers from Cleveland Clinic's Dermatology & Plastic Surgery Institute discovered that women diagnosed with malignant melanoma during their pregnancy or within one year of giving birth were 5.1 - times as likely to die, 6.9 - times as likely to experience metastasis, and 9.2 - times more likely to have a recurrence.

«Once this novel tumor - homing agent binds to the EphA2 receptor, the oncogene functions as a cancer - specific molecular Trojan horse for paclitaxel, carrying the drug inside the cancel cell, killing the cell, and thwarting metastasis,» said Maurizio Pellecchia, a professor of biomedical sciences at UCR's School of Medicine who led the research.

Triple negative patients usually have shorter survival time after diagnosis of brain metastasis, suggesting that these tumor cells adapt much more readily once they've moved to the brain.

Aside from the feat of answering the longstanding question of how the lymph system arises, understanding how it forms and develops can provide important insights into disease, from metastasis to the abnormal accumulation of lymph fluids, particularly in the wake of surgery to remove cancerous tumors.

Tumor metastasis is a leading cause of patient morbidity and mortality, and no treatments are currently available that specifically target metastasis formation.

But when their functioning is altered, as the UCL researchers observed in tumor cells, the mitochondria can promote cell migration, thus leading to the formation of metastasis.

Metastasis, the strategy adopted by tumor cells to transform into an aggressive form of cancer, are often associated with a gloomy prognosis.

The discovery of a treatment capable of blocking the mechanism responsible for the formation of metastasis and the existence of a family of promising compounds, is encouragement for their future assessment in a clinical study that aims to validate a preventive treatment against tumor metastasis.

According to Srikumar P. Chellappan, Ph.D., chair of the Department of Tumor Biology at Moffitt, «these cells can also contribute to the metastasis of tumors as well as the reappearance of tumors after they have been eliminated from the body.»

It is this overproduction of superoxide that leads to the formation of metastasis and, consequently, the growth of a tumor.

This is one of the first research studies to highlight the importance of the location of the metastasis as well as the location of the original primary tumor, in predicting response to radiation therapy.

According to Srikumar Chellappan, Ph.D., chair of the Department of Tumor Biology at Moffitt, «we expect that this study will lead to new therapeutic strategies to combat cancer metastasis.

Excessive adipose or fat tissue, for example, raises circulating levels of estrogen, which is associated with tumor creation and metastasis.

Metastasis, the process that allows some cancer cells to break off from their tumor of origin and take root in a different tissue, is the most common reason people die from cancer.

«Given the devastating impact of cancer metastasis and the dire need for therapies to combat tumor spread, we're highly encouraged by these findings and excited about the therapeutic possibilities they open up.»

Looking to target a key pathway in order to interfere with the processes that lead to tumor spread, a research team led by Irwin H. Gelman, Ph.D., of Roswell Park Cancer Institute (RPCI) has identified a new suppressor of cancer metastasis that may point the way toward development of more effective treatments for prostate cancers and other malignant solid tumors.

The tumor - cell survival factors uncovered by this study might one day be targeted with drugs to further diminish people's risk of metastasis.

«What we may be looking at,» he adds, «is a future way to prevent metastasis to many organs simultaneously» using drugs that make tumor cells let go of the blood vessels they cling to.

«This study has provided strong evidence demonstrating that the molecular signature of metastasis exists prominently in the primary tumor,» says Mary Hendrix, a cancer researcher at the University of Iowa in Iowa City.

In recent years, atypical protein kinase C signaling has been found in the tissue invasion and metastasis of multiple tumors.

Runx2 has been linked to bone metastasis in several solid tumors, though researchers did not analyze the solid tumors for expression of bone - related genes.

Last fall, Bergö's group reported that ingestion of extra antioxidants drove the metastasis of melanoma in a mouse model, though they didn't have any effect on the primary tumor.

With these in vitro test methods, the KU researchers have shown that anti-CD44s antibody can reduce pancreatic cancer cell growth, metastasis and ability of the tumors to recur after radiation therapy.

Part of the cytoskeleton, vimentin gives flexibility and structure to the cell, but it is also a marker of epithelial - mesenchymal transition (EMT), which is considered a crucial event for metastasis in epithelial tumors.

Circulating tumor cell (CTC) clusters — clumps of from 2 to 50 tumor cells that break off a primary tumor and are carried through the bloodstream — appear to be much more likely to cause metastasis than are single CTCs, according to a study from investigators at the Massachusetts General Hospital (MGH) Cancer Center.

Their study, in the journal Oncotarget, is the most extensive analysis to date of gene expression's role in ccRCC tumor growth and metastasis.

One application is the prognosis of the melanoma: the authors show in tumor biopsies that the amount of RAB7 in a cutaneous tumor defines the risk of developing metastasis.

In an article titled, «Allergen Induced Pulmonary Inflammation Enhances Mammary Tumor Growth and Metastasis: Role of CH13L1,» featured on the cover of the current issue of the Journal of Leukocyte Biology, this new research suggests inflammation raises the level of a known biomarker of cancer, called «chitinase -3-like-1» or «CHI3L1,» in the inflamed tissue, which leads to increased metastasis and faster cancer growth in thMetastasis: Role of CH13L1,» featured on the cover of the current issue of the Journal of Leukocyte Biology, this new research suggests inflammation raises the level of a known biomarker of cancer, called «chitinase -3-like-1» or «CHI3L1,» in the inflamed tissue, which leads to increased metastasis and faster cancer growth in thmetastasis and faster cancer growth in that tissue.

This blood vessel normalization results in an increased barrier function on the one hand — thereby blocking cancer cell dissemination and metastasis - and in enhanced tumor perfusion on the other hand, which increases the response of the tumor to chemotherapy.

According to Semenza, «Chemotherapy may kill more than 99 percent of the cancer cells in a tumor but fail to kill a small population of cancer stem cells that are responsible for subsequent cancer relapse and metastasis.»

Loss of either GSTO1 or RYR1, the researchers report, decreased the number of cancer stem cells in the primary tumor, blocked metastasis of cancer cells from the primary tumor to the lungs, decreased the duration of chemotherapy required to induce remission and increased the duration of time after chemotherapy was stopped that the mice remained tumor - free.

Where these three cells come in contact is where tumor cells can enter blood vessels — a site called a tumor microenvironment of metastasis, or TMEM.

Treatment with an investigational CAR T - cell therapy induced complete remission of a brain metastasis of the difficult - to - treat tumor diffuse large - B - cell lymphoma (DLBCL), which had become resistant to chemotherapy — the first report of a response to CAR T - cells in a central nervous system lymphoma.

Investigators found that NPTX2 was expressed in all stages of kidney cancer, especially metastasis, which suggests it plays an important role in tumor development and progression.

Metastasis, or cancer spread by the formation of tumors at new sites, is generally what makes cancers deadly because surgery and other treatments are unlikely to find and destroy every cancer cell.

«If you can get a better handle on the biology of the primary tumor, and the elements of the tumor that may be more or less dangerous, then you don't need to worry about testing every single metastasis for treatment decisions.»

The work also reinforces the importance of finding tumor cell clusters in the blood as a mechanism of detecting cancer metastasis earlier.

The research suggests that a cytokine produced by inflammatory cells near a prostate tumor induces cancer cells to decrease production of a protein that blocks metastasis.

When the protein is present, these cells that start out round and stuck together in a pattern resembling cobblestones become irregularly shaped and tend to detach from the tumor site in an uncoordinated way — hallmarks of metastasis.

To test this idea, the researchers utilized two mouse models of human breast cancer metastasis and found dormant disseminated tumor cells residing upon the membrane microvasculature of lung, bone marrow and brain tissue.

«The result was an extensive inhibition of tumor growth and prevention of metastasis to the lung in HER2 - positive animal models of breast cancer,» notes Navasona Krishnan, Ph.D., a postdoctoral investigator in the Tonks lab who performed many of the experiments and is lead author on the paper reporting the results.

By identifying the cause of this metastasis — which often happens quickly in lung cancer and results in a bleak survival rate — Salk scientists are able to explain why some tumors are more prone to spreading than others.

She is investigating the role of glycosylated molecules in tumor progression and metastasis, tissue - and species - specific expression of lectin receptors that play a role in regulating host innate immune responses and inflammation, and the immunological mechanisms underlying chronic inflammation and cancer development.

Surgeons use this procedure, known as «sentinel lymph node mapping,» to determine the extent of cancer metastasis after removing a tumor.

Tumor metastasis is the primary cause of mortality in cancer patients and remains the major challenge for cancer therapy.

Metastasis (the spread of cancer from its primary site to other places in the body) to the ovaries can result in Krukenberg tumors.