Sentences with phrase «of tumor necrosis factor»

Neurath MF, Fuss I, Pasparakis M, Alexopoulou L, Haralambous S, Meyer zum Büschenfelde KH, Strober W, Kollias G. 1997, «Predominant pathogenic role of tumor necrosis factor in experimental colitis in mice» Eur.

We have initiated studies regarding the hypothesis that the benzamides and nicotinamides could inhibit the production of tumor necrosis factor alpha (TNFalpha) and the inflammatory response as well as induce apoptosis via inhibition of NF - kappaB.

Bruce Beutler and Anthony Cerami provide the first demonstration of the role of tumor necrosis factor in the pathogenesis of disease.

Age is associated with an increase in levels of tumor necrosis factor (TNF) and other pro-inflammatory cytokines in the bloodstream and tissues.

Candidates are several members of the tumor necrosis factor receptor (TNFR) family, and our laboratory is focusing on a number of these molecules.

Similar to capsaicin, tumor necrosis factor is suspected to both induce and reduce cancer cell growth, and was shown to commit cells to survival when stimulating EGFR transactivation mechanisms, indicating that EGFR could act as a molecular switch determining the antiapoptotic effect of tumor necrosis factor (50).

NF - kB enables cancer cells to survive the pro-apoptotic influence of tumor necrosis factor that is released by tumor infiltrating macrophages;

For 5 years, Beckmann was engrossed in many research projects, including an investigation of tumor necrosis factor receptors (TNFRs).

Researchers in Sweden sought to determine if use of tumor necrosis factor inhibitor drugs to treat RA would result in a reduced risk of acute coronary syndrome (commonly called ACS), defined as a diagnosis of a heart attack or unstable angina (the worsening or increasing cardiac symptoms)

Hemorrhagic tumor necrosis during a pilot trial of tumor necrosis factor - alpha and anti-GD3 ganglioside monoclonal antibody in patients with metastatic melanoma.

TIA - 1 and TIAR are related proteins that bind to an AU - rich element (ARE) in the 3» untranslated region of tumor necrosis factor alpha (TNF - alpha) transcripts.

Duntas (2015) articulates, «In susceptible individuals, iodine excess increases intra-thyroid infiltrating Th17 cells and inhibits T regulatory (Treg) cells development, while it triggers an abnormal expression of tumor necrosis factor - related apoptosis - inducing ligand (TRAIL) in thyrocytes, thus inducing apoptosis and parenchymal destruction» (31, p. 721).

Enhanced secretion of tumor necrosis factor, IL - 6, and IL - 1 by isolated lamina propria mononuclear cells from patients with ulcerative colitis and Crohn's disease.

The numerous flavonoids found in astragalus appear to enhance cell - mediated immunity by increasing the number of T - helper cell type 2 cytokines, increasing levels of tumor necrosis factor and interleukin - 6, which stimulates the activity of macrophages, responsible for killing potentially harmful cells.

Michael Croft, Ph.D., and his team focus on a number of molecules that are members of the tumor necrosis factor (TNF) and tumor necrosis factor receptor (TNFR) family, a group of proteins believed to play important roles in the ability of the immune system to guard the body against harmful microorganisms.