Slightly more than 10 % of all patients who undergo successful surgery for prostate cancer have an elevated
risk of tumor recurrence afterwards — especially as metastases.
Cancer stem cells, a type of self - renewing cell found in tumors, are of particular interest because they are the main cell type responsible for tumor progression and for resistance to chemotherapy and radiotherapy, and therefore a major
cause of tumor recurrence after treatment.
The study demonstrated a trend toward a reduction in the incidence
of tumor recurrence in patients who had pelvic RT..
Currently, rising blood levels of prostate - specific antigen (PSA), a protein made by the prostate gland, are used as
indicators of tumor recurrence.
Kancera combines industrial and clinical experience with frontline research to target the
mechanisms of tumor recurrence and develop candidate drugs for new molecular targets.
Not only did the gene's activation seem to underlie newly diagnosed tumors, but it was also an important
driver of tumor recurrence following treatment.
In their paper published online in the Journal of Clinical Oncology, the researchers report that several genetic characteristics of more aggressive tumors were significantly more prevalent in African American patients and appeared to be associated with a greater
risk of tumor recurrence.
If the infiltrated cells are in fact differentiated tumor cells, their dissemination beyond the surgical boundary may not be the primary
cause of tumor recurrence.
Estrogens stimulate the growth of breast tissue, so in theory, the high estrogen levels associated with pregnancy could raise the risk
of tumor recurrence or death in women who have had breast cancer.
«The higher risk
of tumor recurrence that we observed among African American women was reduced when controlling for those factors, suggesting that these genomic differences contribute, at least partly, to the known racial disparity in the survival of African American and Caucasian breast cancer patients.»