Sentences with phrase «of tumor samples from»

Thirty companies and academic groups will receive the same set of tumor samples from individual patients and will try to predict the best neoantigens.

«Furthermore, analysis of tumor samples from large cohorts of colorectal cancer patients revealed that activation of the loop is associated with metastasis,» Hermeking reports.

A multicenter team of researchers reports that a full genomic analysis of tumor samples from a small number of people who died of pancreatic cancer suggests that chemical changes to DNA that do not affect the DNA sequence itself yet control how it operates confer survival advantages on subsets of pancreatic cancer cells.

The finding, reported by a Stand Up to Cancer - Prostate Cancer Foundation Dream Team in the May 21 edition of the journal Cell, is based on an analysis of tumor samples from 150 men with metastatic prostate cancer that no longer responded to standard hormone - blocking therapy.

She has sequenced hundreds of tumor samples from across the island in an effort to understand how it evolves and how that affects the devils» survival rates.

Not exact matches

To determine how the cells switch from one type to another, they took three human uterine carcinosarcoma samples and sequenced the genomes of cells in two parts of each tumor: the carcinoma and sarcoma components.

For example, TCGA, with genomic data on 33 tumor types taken from samples from 11,000 patients, is finishing 2018 by publishing a series of papers and holding a symposium.

The focus of those hopes is the liquid biopsy: a test that could detect and analyze a solid tumor from biomarkers in the bloodstream or other easily sampled body fluids, such as saliva.

Even after initial purification of the sample, liquid biopsies typically contain much more nucleic acid from healthy cells than from tumors.

HBI member V. Wee Yong, PhD and research associate Susobhan Sarkar, PhD, and their team including researchers from the Department of Clinical Neurosciences and the university's Southern Alberta Cancer Research Institute, looked at human brain tumor samples and discovered that specialized immune cells in brain tumor patients are compromised.

In blood samples from 1005 patients with eight types of tumors that had evidently not yet metastasized, the test detected between 33 % and 98 % of cases, depending on the tumor type (see graph, above).

31: The percentage of genetic mutations shared by all the tumor samples taken from a patient with kidney cancer.

«This gives us novel and exciting new therapeutic options to pursue based on results from drug screenings of primary tumor samples from patients.»

Researchers said the importance of collecting tissue samples from recurrent tumors will grow as more targeted therapies become available.

To that end, in collaboration with the University of Zurich and MD Anderson Cancer Center, the researchers tested melanoma tumor samples from human patients undergoing treatment with the same targeted therapies.

The investigators looked at 4,278 tumor samples from a tissue repository of patients with GI tract cancers.

Spearheaded by first author Christopher McNair, PhD, a graduate student in the laboratory of Dr. Knudsen, the study undertook an extensive analysis of tumor samples and cell - free DNA samples from patients with advanced, lethal - stage prostate cancer.

Using tumor samples from a patient, they do lab tests to determine which substances can first make the different types of cancer cells uniform and then effectively kill them.

A global analysis of metabolites and small molecules in urine samples from patients with adrenal cancer has identified four biochemicals that, when measured together, can distinguish malignant from benign adrenal tumors, according to study results presented at the 2015 Annual Clinical Congress of the American College of Surgeons.

Analysis of blood and tissue samples from one patient revealed that plakoglobin was expressed in CTC clusters but not single CTCs and also was expressed in some portions of both the primary tumor and metastases.

Using tumor samples from the Women's Healthy Eating and Living clinical trial, researchers identified stem - like tumor cells as being characterized by low levels of the molecule p53 upregulated modulator of apoptosis (PUMA).

From tissue and cell samples from five glioblastoma patients, the scientists obtained 33 individual cancer cells capable of reproduction, which grew into very different tumors in the From tissue and cell samples from five glioblastoma patients, the scientists obtained 33 individual cancer cells capable of reproduction, which grew into very different tumors in the from five glioblastoma patients, the scientists obtained 33 individual cancer cells capable of reproduction, which grew into very different tumors in the lab.

A total of 67 biochemical features discriminated cancer from benign tumors in these samples, but only four specific metabolites could be considered as biomarkers for cancer: creatinine riboside, tryptophan, Nε, Nε, Nε - trimethyllysine, and 3 - methylhistidine.

A new investigation of more than 48,000 stored tumor samples finds evidence of a key deficiency in a repair mechanism designed to keep DNA from being mutated and causing cancer.

To see whether Lin28 might be a factor in Wilms tumor development, Daley and an international team of collaborators measured the gene's expression in tumor samples from 105 Wilms patients.

To streamline this process, Uhlén's team has created standardized arrays containing microscopic samples from 48 kinds of normal human tissue and 20 types of tumors.

To better understand the formation of metastases in pancreatic cancer, Christine Iacobuzio - Donahue, M.D., Ph.D., professor of pathology at Memorial Sloan Kettering Cancer Center, collected tumor samples from eight patients with the most common form of pancreatic cancer (pancreatic ductal adenocarcinoma) immediately after their deaths.

The researchers next will turn to analyzing the presence of myoferlin in samples from numerous human tumor types available in an Ohio State tissue bank, which will allow them to compare protein levels in tumors to clinical outcomes for the patients who provided the samples.

Unlike other solid tumors, there has been limited progress in understanding the contribution of genetic risk factors to the development of uveal melanoma, researchers say, primarily due to the absence of comprehensive genetic data from patients as the large sample cohorts for this rare cancer type have not been available for research.

«In the tumor sample from a patient with high NRP - 1 expression, there was a significant improvement in the efficacy of the nanoparticle to induce tumor shrinkage,» said Nel.

Using all the existing data that was available, Andrechek, along with MSU doctoral student Daniel Hollern, analyzed 1,172 mouse mammary tumor samples from 26 different preclinical models and was able to compile one of the largest databases to show which strains of mice were best suited to study a particular type of human breast cancer.

Analyzing the poly - G profiles of primary and metastatic colon cancer samples from 22 patients revealed that how the primary and metastatic tumors related to each other was different for each patient.

Cells were extracted from the biopsy of her tumor sample for use in research without her knowledge or consent.

Answering important clinical questions — such as whether genetic diversity is a risk factor for aggressive tumor development or how it relates to treatment resistance — requires analyzing samples from many patients with different types of cancer.

The researchers were able to replicate this finding by comparing the healthy thyroid tissues in GTEx to 500 samples taken from thyroid tumors, compiled by The Cancer Genome Atlas, and giving support to the extensive impact of FOXE1 on cellular state.

The total environmental DNA of grape crown gall tumor disease is revealed in the genetic profile based on 52 tissue samples of crown gall tumor taken from 16 grapevine species.

Information obtained via single - cell sequencing from cells sampled from each core indicate the likely location of a cancerous tumor (dotted lines encompassing cores 2, 3 and 6).

To confirm that the missing mutations were important for generating an immune response, the researchers cultured a subset of the neoantigen protein fragments containing the tumor mutations with immune cells taken from three patients» blood samples.

Analysis of liver tumor samples from patients showed that NRF2 expression correlated with tumor metastasis.

Working in mouse models of breast cancer and breast tumor samples from patients, Longmore and his colleagues showed that a protein that sits on the surface of tumor cells, called DDR2, binds to collagen and activates a multistep pathway that encourages tumor cells to spread.

To search for other characteristics of ccRCC tumors that influences immunotherapy response or resistance, the researchers used whole - exome DNA sequencing to analyze tumor samples from 35 patients treated in a clinical trial with the checkpoint blocker nivolumab (Opdivo).

Researchers also can't draw inferences from a single sample on the frequency of tumors in the Neandertal population, he says.

In the first cohort, researchers led by Jeeyun Lee, MD, from Sungkyunkwan University School of Medicine in Seoul, performed whole exome sequencing on samples from paired synchronous primary and metastatic tumors.

The researchers used an enhanced version of a technique they developed called CAPP - Seq to isolate and sequence circulating tumor DNA, or ctDNA, from blood samples from the patients.

Overall, including all genomic variations present in most if not all tumor cells (clonal) as well as those present only in subsets of the cancer cells (subclonal) from tumor tissue, the researchers detected a total of 864 genetic changes in tissue samples across the three tumor types, and 627 (73 %) of those were also found in the blood.

In a landmark paper, Cancer Research UK funded scientists alongside an international team of researchers read all of the DNA in tumor samples from 10 men with prostate cancer.

In collaboration with Dr. Omer Iqbal, from the Department of Pathology, they are analyzing the genetics and biology of tumor samples to find how they differ from samples of tumors not linked to radiation.

Searching for T cells that had infiltrated the tumors, they collected as many as 50 T cell samples from a single tumor; next, the team tested each batch of T cells against other tumor samples from the same patient.

Notably, the researchers found that, using their methods, highly reactive TILs could be obtained from some 90 % of the ovarian cancer patients whose tumor samples they examined.

Charles Swanton, a cancer geneticist at the Francis Crick Institute in London, and colleagues analyzed 1,206 clear - cell renal cell carcinoma (ccRCC) tumor samples from 101 patients as part of the Tracking Cancer Evolution through therapy (TRACERx) program.