Sentences with phrase «of tumor sequencing»

No doubt we'll be revisiting lung cancer, for which we sequenced candidate genes as part of the Tumor Sequencing Project (TSP) consortium.

Secondary rounds of tumor sequencing — possible now that the cost has fallen dramatically — could point to new mutations acquired by their cancer cells, thus suggesting further treatments.

Not exact matches

Led by Nina Bhardwaj, M.D., director of immunotherapy, the Personalized Genomic Vaccine trial uses the genetic sequence of a patient's tumor to create a customized vaccine.

It will focus its initial clinical sequencing efforts on cancer, teaming up with the Moores Cancer Center at the University of California, San Diego to sequence the genomes of every patient who is treated there, as well as perform a full genome sequence on their tumors.

To determine how the cells switch from one type to another, they took three human uterine carcinosarcoma samples and sequenced the genomes of cells in two parts of each tumor: the carcinoma and sarcoma components.

While the latter has a reputation for being hard to isolate, she explains that even degraded RNA generally contains enough intact sequence to analyze — provided investigators can detect the scarce tumor signals against the immense background of other RNA molecules in a sample.

Zhang's group is moving beyond bulk sequencing of tumor samples and is now conducting genomics on single cells.

This quantitative, targeted, multiplexed approach leverages the power of next - generation sequencing and PCR technologies, and allows the researcher to obtain a molecular snapshot of the tumor microenvironment.

A patients» tumors from cholangiocarcinoma, a rare liver cancer that typically fails chemotherapy, shrunk significantly after treatment with FGFR inhibitors, which were prescribed based on results of next generation sequencing.

Three separate groups have performed advanced sequencing on ependymomas, a tumor that occurs at the part of the brain called the posterior fossa, which is the back base of the brain including the cerebellum, pons and brainstem.

«Next generation sequencing tools were used to profile patients» tumors,» said Razelle Kurzrock, MD, director of the Center for Personalized Cancer Therapy at UC San Diego Moores Cancer Center.

The Michigan Oncology Sequencing Program (MI - ONCOSEQ) facilitates integrative sequencing analysis of tumors from patients with advanceSequencing Program (MI - ONCOSEQ) facilitates integrative sequencing analysis of tumors from patients with advancesequencing analysis of tumors from patients with advanced cancers.

A tissue slice, a tumor biopsy, or a sample of a bacterial culture yields a sequence representing the average of all of the cells within it, even though researchers know there can be tremendous variation between those cells.

In Mardis» vision of the future, doctors will sequence each patient's tumor to zero in on its unique vulnerabilities and shut down its malfunctioning genes.

Constructing a complete map of all of the genetic variation within even a small tumor, for example, would require sequencing trillions of single cells.

She has sequenced hundreds of tumor samples from across the island in an effort to understand how it evolves and how that affects the devils» survival rates.

In the next phase of the study, researchers will genetically sequence tumor cells from at least 500 patients and follow the course of their disease.

«Studies like the current one involving rhabdomyosarcoma are giving us a close - up look at the way cancer evolves in response to treatment,» said study co-author Richard K. Wilson, Ph.D., director of The Genome Institute at Washington University School of Medicine in St. Louis, where scientists have extensive expertise analyzing tumor recurrence using whole - genome sequencing.

Sequencing a single genome yields a terabyte or more of data; Dishman's kidney tumor yielded 5 terabytes.

They identified ALK - positive mesotheliomas by immunohistochemistry; confirmed with fluorescence in situ hybridization; and performed targeted next - generation sequencing of tumor DNA and RNA to get a full picture of the exact genetic rearrangement underpinning the disease.

Moderna is also doing animal safety tests of a personalized cancer vaccine that would code for immune - activating proteins unique to a person's cancer cells, based on genetic sequencing of their tumor.

The researchers analyzed the samples using immunohistochemistry and RNA sequencing to study the changes in the tumor immune microenvironment of patients who received and did not receive chemotherapy, and changes before and after chemotherapy.

Of the 104 screened patients, 102 enrolled with 91 (89 percent) having adequate tumor tissue to complete sequencing.

The latter, presented by Eric Lander of the Broad Institute in Cambridge, Massachusetts, would systematically sequence tumor samples for mutations involved in cancer to speed up the search for new drugs and diagnostics.

The 15 AACR scientists, who were already in Washington, D.C., to meet with the U.S. Food and Drug Administration on genetic testing for cancer patients, tossed around ideas including expanding NCI's tumor genome - sequencing efforts and getting the government to cover the costs of genomic tumor profiling.

The team integrated three, complementary gene sequencing approaches to look for mutations in tumor cells from SS patients: whole - genome sequencing in six subjects, sequencing of all protein - coding regions (exomes) in 66 subjects, and comparing variation in the number of copies of all genes across the genome in 80 subjects.

RNA sequencing of both single and clustered CTCs from breast cancer patients identified several genes expressed at elevated levels in CTC clusters, one of which — a protein called plakoglobin — also was overexpressed in the primary tumors of patients with reduced survival.

His laboratory develops and deploys new biochemical and computational methods in functional genomics, to elucidate the genetic basis of human disease and human physiology, and to create and deploy novel techniques in next - generation sequencing and algorithms for tumor evolution, genome evolution, DNA and RNA modifications, and genome / epigenome engineering.

Three years earlier, investigators had found genetic sequences of the novel retrovirus in prostate tumors from men with that disease.

Navin's team developed a new sequencing approach called Nuc - Seq, revealing that different subtypes of breast cancer displayed varied tumor diversity.

Upon sequencing the DNA, they found that DNA fragments containing mutated genes — markers of tumors — were typically smaller than healthy versions of the gene from within the same patient.

A multicenter team of researchers reports that a full genomic analysis of tumor samples from a small number of people who died of pancreatic cancer suggests that chemical changes to DNA that do not affect the DNA sequence itself yet control how it operates confer survival advantages on subsets of pancreatic cancer cells.

Hadfield and his colleagues are doing large - scale genomic analyses of different tumor types, as part of the massive Genomics England project to sequence 100,000 British genomes.

To illuminate the process, the Yale team sequenced normal, primary, and metastatic tumor tissue from multiple individuals, including subjects with a range of cancer types.

DNA sequencing demonstrated how cancer evolved from a primary tumor in the cervix to metastases in the kidney, liver, and ovary of a patient.

In 2011, she joined the institution's molecular diagnostics laboratory where she has been developing translational next generation sequencing assays and bioinformatics workflows for the Molecular Tumor Profiling Lab of the Yale Cancer Center.

During the last three years the Spanish Consortium for the Study of the Genome of the Chronic Lymphatic Leukemia, where the researchers of the present study already collaborate, has sequenced the genome of hundreds of patients with the more common leukemia in our society, identifying new mechanisms of tumor progression and new therapeutic targets.

Unregulated growth is due in large part to the fact that tumor cells can rebuild protective ends of their chromosomes, which are made of repeated DNA sequences and proteins.

Without the genome sequence of Lacks» healthy cells or that of her original tumor, it is difficult to trace the origin of these alterations.

Of the several thousand cancer patients treated annually at the Heidelberg National Center for Tumor Diseases (NCT), whole - genome sequencing of tumors is offered to all patients who might benefit, says EilOf the several thousand cancer patients treated annually at the Heidelberg National Center for Tumor Diseases (NCT), whole - genome sequencing of tumors is offered to all patients who might benefit, says Eilof tumors is offered to all patients who might benefit, says Eils.

New research from George Vasmatzis, Ph.D., of the Department of Laboratory Medicine and Pathology at Mayo Clinic, finds liquid biopsies from blood tests and DNA sequencing can detect a return of ovarian cancer long before a tumor reappears.

First, iCAGES analyzes the patient's entire genome, comparing it to the genomic sequence of the patient's tumor to identify possible cancer - causing variants.

Surprisingly, they found that although the patterns of gene expression — as shown by the RNA sequencing — differed between the hepatocellular carcinomas and the liver cancers with biliary phenotype and depended on the histological type, the overall pattern of mutations in the cells was actually similar between the tumors — of either type — that had emerged in patients who had had infections with either hepatitis C or B, and were different in patients without such infections.

Cranberries also contain a number of compounds that benefit human health — including some that have been shown to inhibit the growth of tumor cells — and sequencing work may reveal more about them.

This led to development of newer technology, called single cell sequencing (SCS), that has had a major impact in many areas of biology, including cancer research, neurobiology, microbiology, and immunology, and has greatly improved understanding of certain tumor characteristics in cancer.

The research team developed a new method called highly multiplexed single - nucleus sequencing (HM - SNS) to investigate CNA's clonal substructure and evolution in a cohort of 12 TNBC patients, whose tumors had been surgically removed prior to further therapy.

HM - SNS allows researchers to sequence the genomes of single tumor cells and study multiple cells simultaneously, both lowering the cost and boosting data analysis for such studies.

NYGC computational biologists and members of the Simon Laboratory at The Rockefeller University discussed the possibility of using a series of computer algorithms to search for sequence differences between the tumor samples and samples of healthy liver tissue.

Information obtained via single - cell sequencing from cells sampled from each core indicate the likely location of a cancerous tumor (dotted lines encompassing cores 2, 3 and 6).

A University of Colorado Cancer Center study published in the journal Oncogene used next - generation sequencing technologies to perform the most detailed DNA - based analysis to date of 25 commonly used bladder cancer cell lines, allowing researchers to match patient tumors with their closest genetic cell line match, and demonstrated genetic alterations that may make cells more or less sensitive to common therapies.