Sentences with phrase «of tumor suppressor»
Most importantly, it prevents the degradation of the tumor suppressor protein p53.
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Mutation in a tumor suppressor gene acts in the opposite way, causing cancer in a recessive fashion by inactivation of the tumor suppressor protein.
Romidepsin (Istodax) and vorinostat (Zolinza) inhibit enzymes called histone deacetylases (HDACs) that tighten the coil around DNA and block expression of tumor suppressor genes.
Her graduate work culminated in multiple publications in the field of cancer epigenetics and in a thesis entitled «Aberrant epigenetic silencing of tumor suppressor genes in human cancer: the roles of DNA hypermethylation and the histone code.»
Cyanidin increased SIRT6 enzyme levels in human colorectal cancer cells, and it was also discovered to decrease the expression of the Twist1 and GLUT1 cancer genes, while increasing the expression of the tumor suppressor FoXO3 gene in cells.
These findings explained why many patients only display partial loss of this tumor suppressor when diagnosed with prostate cancer.
Wilms» tumor is a childhood kidney cancer caused by the loss or inactivation of a tumor suppressor gene called QT1 on chromosome 11.
His growth - regulation research is now focused primarily on the DLC family of tumor suppressor genes and their mechanism of action.
Michelle Barton, Ph.D., was nominated and elected by her scientific peers in recognition for her contributions to understanding the function of the tumor suppressor, p53 in stem cells, particularly with respect to the discovery of TRIM24, an E3 - ligase and epigenetic regulator that is overexpressed in many cancers.
Methylation of tumor suppressor genes has been shown by Kimmel Cancer Center investigators to silence them, allowing cancers to start.
Dr. Almog received a Ph.D. from the Weizmann Institute of Science, Israel, where she was studying the molecular mechanisms regulating the activity of the tumor suppressor protein p53.
These two histones thus have a key role of epigenetic silencing of tumor suppressor genes in breast cancer (and likely other cancers), suggesting that they may represent new therapeutic targets.
Researchers have found the first connection between the loss of a tumor suppressor gene and activation of a cancer - promoting oncogene, a scenario thought to be prevalent in the initiation of many...
She chose the dynamics and function of the tumor suppressor protein p53, which plays a key role in cancer and is widely studied.
Other animal models either express oncogenes in a tissue - specific manner or shut down the expression of tumor suppressor genes in the whole tissue.
Dr. Eng and team create scoring system to facilitate identifying individuals to be referred to PTEN gene testing Researchers have discovered a method for more precise identification of individuals who should undergo testing for genetic mutations of the tumor suppressor gene PTEN, which associates with a variety of conditions including several types of cancers.
Howard Hughes Medical Institute (HHMI) researchers at the Memorial Sloan Kettering Cancer Center in New York have determined the three - dimensional structure of a tumor suppressor protein inactivating...
P53: The protein p53 plays the role of tumor suppressor, but creating a general increase in p53 levels will, in addition to reducing cancer incidence, also accelerate aging by reducing tissue maintenance through the creation of new cells.
Phosphatase and tensin homolog (PTEN): Adding an extra copy of the tumor suppressor gene PTEN to mice produces lower rates of cancer, much as expected, but also increased life span.
The cell cycle regulator p21 mediates the ability of the tumor suppressor p53 to arrest cellular proliferation.
We have found that the initiation of pancreatic cancer does not follow the classic paradigm seen in colon cancer where loss of a tumor suppressor gene initiates tumorigenesis and then acquisition of an oncogene promotes tumor formation.
Inactivation of the tumor suppressor gene RASSF1A by promoter hypermethylation represents a key event underlying the initiation and progression of lung cancer.
Loss of tumor suppressor p53 decreases PTEN expression and enhances signaling pathways leading to activation of activator protein 1 and nuclear factor kappaB induced by UV radiation.
In breast cancer, miR - 7 was shown to block invasiveness and tumorigenic potential by targeting PAK, which is consistent with the idea of tumor suppressor function of miR - 7 (25).
When normal diploid cells lose one or both copies of tumor suppressor genes, cancers can form.
«We found polyploidy in liver cells did not strongly affect the activity of some oncogenes, but it did protect against the loss of tumor suppressor genes.
They discovered that the number of tumor suppressor genes or oncogenes in a chromosome correlated with how often the whole chromosome or part of the chromosome was deleted or duplicated in cancers.
This study aimed to determine whether epithelial - derived MMP9 has a defensive role of tumor suppressor in CAC and the underlying molecular mechanism.
Loss of the tumor suppressor p53 often contributes to therapy resistance in tumors.
The loss of the tumor suppressor gene PTEN has been linked to tumor growth and chemotherapy resistance in the almost invariably lethal brain cancer glioblastoma multiforme (GBM).
There is no way to directly target the loss of the tumor suppressor, but Ler et al. found another strategy to effectively treat tumors with this mutation.
Loss of tumor suppressor KDM6A amplifies PRC2 - regulated transcriptional repression in bladder cancer and can be targeted through inhibition of EZH2
In a previous study, his team worked with other collaborators to identify the potential role of extra copies of the tumor suppressor gene (p53) that increase the elephant's ability to eliminate pre-cancerous cells with DNA damage.
Mice with only one working copy of tumor suppressor Mus81 have prostate (left) and muscle (right) cancers, among others.
Dozens of tumor suppressor genes have been identified, but most are poorly understood.
A single addition or subtraction of a few carbon and hydrogen ions can determine the silencing of a tumor suppressor gene or the overexpression of an oncogene.
Working with colleagues at St. Vincent's Hospital in Sydney, Martin identified two individuals who had the characteristics of hereditary nonpolyposis colorectal cancer, which is usually caused by a mutation that inactivates one of a person's two copies of the tumor suppressor gene MLH1, but who showed no signs of mutation.
«Epigenetic silencing of tumor suppressor promotes endometrial cancer.»
After EZH2 enzymes rise, their levels taper off, and then, the scientists found two to three-fold increases in a protein called DNMT1, which maintains DNA methylation in the «start» location of a variety of tumor suppressor genes that normally suppress cell growth.
Preferential glycolysis has been associated with activated oncogenes and loss of tumor suppressors, both of which confer other hallmark capabilities on cancer cells.
During the multistep process of carcinogenesis, decreased expression of tumor suppressors is often caused by epigenetic modification or abnormal degradation (48, 49).
Downregulation of tumor suppressors and upregulation of proto - oncogenes can directly inhibit the ability of a cell to undergo programmed cell death while simultaneously stimulating growth and division.
Combining genetics, live - imaging, laser ablation and computer simulations, we aim to analyze whether distinct or similar mechanisms can account for the common role of tumor suppressors and proto - oncogenes in cell - cell contact regulation.
Not exact matches
However, the impact of the two methylation - regulating enzymes was still seen at 10 to 15 months, when scientists found decreased expression of hundreds of genes — many of which are key tumor suppressor genes such as BMP3, SFRP2 and GATA4 — in the smoke - exposed cells and a five - or - more-fold increase in the signaling of the KRAS oncogene that is known to be mutated in smoking - related lung cancers.
However, no mutations were found in the KRAS gene itself or the tumor suppressor genes during the 15 - month period of cigarette smoke exposure.
BRCA1 is a tumor - suppressor gene; the deletion of the two letters disabled its protective function.
In this special section of Science, expert contributors retrace the long and tortuous path leading to the mapping and identification of the BRCA1 gene; discuss the ways in which BRCA mutation status has been integrated into the clinical management of patients in high - risk families; and highlight the role of the BRCA proteins in preserving the structural and numerical integrity of chromosomes throughout the cell cycle, a function that may explain their tumor suppressor activity.
One type of cell, the polymorphonuclear myeloid - derived suppressor cell (PMN - MDSC), was present exclusively in the induced tumors.
A pre-clinical study of two drugs designed to boost T cell performance, has revealed the agents, when give in combination, may enhance the immune system's ability to kill melanoma tumors deficient in the tumor suppressor gene PTEN.
«Our study identified miR - 182 as a glioblastoma tumor suppressor that reduces the expression of several oncogenes that promote cancer development,» said senior author of the study Alexander Stegh, an assistant professor in the Ken and Ruth Davee department of neurology and of medicine at Northwestern University Feinberg School of Medicine.