Sentences with phrase «of tumor xenografts»

In these experiments, Berger and colleagues show that somatic PREX2 mutations identified through whole - genome sequencing of human melanoma can contribute to enhanced lethality of tumor xenografts in nude mice (Figure 3B, S6B, and S6C; Berger et al., 2012).

Not exact matches

EZH2 inhibition delayed tumor onset in KDM6A - null cells and caused regression of KDM6A - null bladder tumors in both patient - derived and cell line xenograft models.

We then usually move onto xenograft models and then also, if available, try to test some of these compounds in genetically engineered mouse models that have particular mutations driving tumor formation.

In a 1988 paper summarizing his findings, Fiebig concluded that xenograft mice were wonderful models for broadly testing new drugs against human tumors, but they «can not be used as a clinical routine method» for predicting patient treatment.1 The idea of using xenograft mice as personal avatars for cancer patients was discarded.

The researchers used an in vivo model of PARP inhibitor resistance in patient - derived tumor xenografts (PDXs).

«There is some talk of going into 3 - D cell models rather than xenografts, because it is so difficult and challenging to grow [the transplanted tumors],» says Manish Kohli, the Mayo Clinic oncologist leading the PROMOTE study.

Using 80 of the successful tumor xenografts — from the Greek «xenos» meaning «foreign» — he compared how the mouse's tumor responded to a drug or drug combination with the treatment response of the corresponding human patient.

NCI's efforts to develop new laboratory models of human cancer includes vastly increasing the number of human cancer cell lines (grown as two - dimensional and three - dimensional cultures) and patient - derived tumor xenografts.

Due to the high efficiency of establishing organoid models from different tissues and diseases, such as cancer, organoid technology allows the generation of large living biobanks of tumor organoids that are amenable for middle - throughput drug screens and may allow personalized therapy design, as a complement to cell line and xenograft - based drug studies (7,19).

Zebrafish larva implanted with cancer patient's tumor (red) RITA FIOR / CHAMPALIMAUD CENTRE FOR THE UNKNOWNSee R. Fior et al., «Single - cell functional and chemosensitive profiling of combinatorial colorectal therapy in zebrafish xenografts,» PNAS, doi: 10.1073 / pnas.1618389114, 2017

Finally, I have a category of «other cancers» with exomes published in 2011; these include pancreastic cysts and cell lines, gastric cancer tumors, and prostate cancer samples derived through mouse xenograft models.

Comparative genomic hybridization showed a normal pattern in the first case and a gain of chromosomal 12 in the xenografted tumor.

In a xenograft KMT2D - mutated T - lymphoma model, dual treatment with chidamide and decitabine significantly retarded tumor growth and induced cell apoptosis through modulation of the KMT2D / H3K4me axis.

(G) Immunostaining of p - ERK in tumor samples of xenografted murine models bearing KMT2D V5486 mutants treated with CHID and / or DECI.

In - vivo treatments of xenografted tumors showed significant tumor growth inhibition induced either by rituximab or gemcitabine alone and an impressive efficacy of combined treatment.

In a series of lab experiments with cell lines, human xenograft tumors in mice and primary human prostate cancer samples, the researchers demonstrated that miR - 34a inhibits prostate cancer stem cells by suppressing CD44.

It was indeed found DAXX promotes the in vivo tumorigenicity of two human PCa cell lines in a subcutaneous tumor xenograft model via suppression of autophagy [Submitted].

Accordingly, p - ERK upregulation was observed not only in tumor samples of PTCL - NOS patients with KMT2D mutations, but also in those of xenografted T - lymphoma mice bearing KMT2D V5486M mutants, the latter being inhibited by combined treatment with chidamide and decitabine (Figure 5F, G).

We also found that the EphB4 receptor expressed on the surface of breast cancer cells can promote tumor xenograft growth by enhancing blood vessel formation through interactions with its preferred ligand, ephrin - B2, present in tumor endothelial cells.

We have recently reported that the GHRH antagonist, MIA - 602, suppresses the expression of inflammatory cytokines in human TNBC tumors xenografted into nude mice.

Intraperitoneal injection of the HIF - 1α inhibitor, YC1, following tumor initiation reduces the hypoxic CSC effect in MCF7 xenografts and results in no correlation between xenograft size and MFC (Fig. 5C).

Confocal fluorescence micrographs of tumor sections from MCF7 / HER2 xenografts.

On the contrary, recent evidence indicates that XMRV is a contaminant originating from the recombination of two mouse endogenous retroviruses during passaging of a prostate tumor xenograft (CWR22) in mice, generating laboratory - derived cell lines that are XMRV - infected.

A study by Pauli and colleagues in this issue of Cancer Discovery describes the creation of a precision cancer platform for patients with advanced disease, integrating DNA sequencing of patient tumors with the generation of patient - derived organoids and xenografts.

Liu JF, Palakurthi S, Zeng Q, Zhou S, Ivanova E, Huang W, Zervantonakis IK, Selfors LM, Shen Y, Pritchard CC, Zheng M, Adleff V, Papp E, Piao H, Novak M, Fotheringham S, Wulf G, English J, Kirschmeier PT, Velculescu VE, Paweletz CP, Mills GB, Livingston DM, Brugge JS, Matulonis UA, Drapkin R.: Establishment of patient - derived tumor xenograft models of epithelial ovarian cancer for pre-clinical evaluation of novel therapeutics.

The approach is to use clinically relevant tumor models such as patient - derived xenografts (PDXs), as well as humanized and immunocompetent transgenic tumor - bearing mice to design rational combinations of novel and emerging cancer therapies, including tumor - targeting and immune - stimulating therapies, to ultimately improve treatment outcomes for cancer patients.

We next tested the ability of antibody - expressing NSCs to deliver anti-HER2 antibodies to tumor foci in vivo using a xenograft nude - beige mouse model.

Importantly, an inverse correlation was observed for ER - α — negative lines with a decrease in the proportion of MFC within the xenograft as tumor size increases (Fig. 5Bii).

Subcutaneous tumor cell implantation and purification of tumor cells from xenograft tumors.

Autophagy inhibition synergistically enhances anticancer efficacy of RAMBA, VN / 12 -1 in SKBR - 3 cells, and tumor xenografts.

This included evaluation of tumor burden in mice orthotopically xenografted, as well as analysis of the overall rate of survival.

Sulforaphane, a putative anticarcinogen in broccoli, was provided orally to mice bearing androgen - insensitive human PC - 3 xenografts, and resulted in tumor volumes of 207 ± 35 and 90 ± 22 mm3 for the control and sulforaphane groups, respectively (22).