Uterine leiomyomas, also called fibroids, cause a very significant burden to women's health but relatively little has been known about the
mechanisms of tumorigenesis involved.
This protein belongs to the human protein family PIF1, the mutations of which are known to be associated with a higher
risk of tumorigenesis.
«The vaccination approach we have employed is not prophylactic but therapeutic, meaning that immunity was induced after the
onset of tumorigenesis — a scenario that resembles the clinical conditions much more closely than prophylactic immunization studies, says Anna - Karin Olsson, researcher at the Department of Medical Biochemistry and Microbiology at Uppsala University,» who has led the study.
«With a better understanding of the epigenetic landscapes in cancers, we are going to have more tools to study the
basis of tumorigenesis,» says Ren.
GPCRs and their downstream signaling are involved in cancer growth and development by controlling many
features of tumorigenesis, including immune cell - mediated functions, proliferation, invasion and survival at the secondary site.
After a two - year stint as a postdoctoral research fellow in Pharmacology in the laboratory of Dawn Quelle at the University of Iowa, where I studied the molecular
mechanisms of tumorigenesis, I made the switch to industry.
These «passenger» genes are differentially expressed between normal and tumor tissues, but they are not «drivers»
of tumorigenesis.