Sentences with phrase «of tumour development»

This could be due mostly to the hypoglycemia stalling the rate of tumour development.

The Pan-Cancer consortium has included the tool in order to gain a more global view of the causes of tumour development.

Not exact matches

Comrades, developments over the past year on both the political and social front have once again exposed the extent of political and social disorder and dishonesty that is eating our country up like a malignant tumour — a debilitating cancer!

In conclusion, this new study identifies the cellular origin of Pik3ca - induced tumours and reveals that oncogenic Pik3ca activates a multipotent genetic program, setting the stage for future intratumoural heterogeneity at the earliest stage of tumor development.

These results have important implications for the understanding of the mechanisms controlling tumour heterogeneity and the development of new strategies to block PIK3CA induced breast cancer.

The Lund University research team has looked at how cancer cells communicate with surrounding cells and how this encourages the development of malignant tumours.

The importance of exosomes in the tumour microenvironment has been demonstrated within the field in recent years, as it has been shown that tumour development is halted if the production of exosomes inside the cancer cell is stopped.

Peng Loh of the National Institute of Child Health and Human Development in Bethesda, Maryland, and colleagues studied tumours from 99 people with liver cancer.

Broccoli extract has been shown to have an epigenetic influence so the team is interested to see if that affects the development of tumours, she says.

Published in the journal Cancer Research, the discovery has potential to lead to the development of a blood test that could predict whether cancer will spread from the prostate tumour to other parts of the body.

Their experiments in pre-clinical models proved to be successful, confirming lower tumour development with the regulation of the proteins that affect production of VLDL (precursors of LDL) and uptake of LDL by receptors from the liver.

Until now, it was not clear which form of cell death is decisive for the development of malignant liver tumours.

However, occasionally germ cells can get trapped in the wrong part of the body during development and may later turn into brain tumours, for example.

Breast cancer cells that spread to other parts of the body break off and leave the primary tumour at late stages of disease development, scientists from the Wellcome Trust Sanger Institute and their collaborators have found.

The team found that most of the genetic changes in the original breast tumour were also present in the metastatic tumours, showing that the cancer cells spread late in disease development.

The largest - ever study to sequence the whole genomes of breast cancers has uncovered five new genes associated with the disease and 13 new mutational signatures that influence tumour development.

The adhesive properties of cancer cells play a key role in the formation and development of a tumour.

Professor Geoff Pilkington, study co-author and Head of the Brain Tumour Research Centre, said: «Although this work is still at an early stage, we have demonstrated key elements that are associated with tumour cell binding to blood vessels and this may provide a target for future drug development to prevent the development of secondary tumours in the Tumour Research Centre, said: «Although this work is still at an early stage, we have demonstrated key elements that are associated with tumour cell binding to blood vessels and this may provide a target for future drug development to prevent the development of secondary tumours in the tumour cell binding to blood vessels and this may provide a target for future drug development to prevent the development of secondary tumours in the brain.

«Females do not find a mating partner within the small isolated populations any more,» explains Petra Kretzschmar, scientist at the Leibniz Institute for Zoo and Wildlife Research (IZW), «the long non-reproductive periods lead to the development of reproductive tract tumours.»

Increasing our understanding of the adhesive properties of tumours may also help to develop new treatments to halt the development and spread of primary brain tumours.»

Cell migration is highly coordinated and occurs in processes such as embryonic development, wound healing, the formation of new blood vessels, and tumour cell invasion.

The discovery could help with future development of novel treatments to prevent metastasis and secondary tumours.

Heparanase dysfunction is linked to the spread of cancers both through the breakdown of this matrix and via the subsequent release of «growth factors» — chemicals that promote tumour development.

Angiogenesis inhibition is commonly targeted in cancer treatment development that aims to starve tumours of the nutrients necessary for their survival.

It could also lead to the development of new breast cancer drugs to target tumours with a specific genetic make - up.

In the context of cancer, a high level of ROS is a major player in tumour development and growth.

By conducting an RNA - sequencing experiment of 103 matched tumour and normal colon mucosa samples from Danish CRC patients, 90 of which were germline - genotyped, researchers from the collaborative European project SYSCOL show that both inherited and acquired mutations in non-coding regions of the genome also contribute to cancer development and progression (Linda Koch, Nature Reviews Genetics).

The discovery of new genes involved in these repair mechanisms is very important in order to understand the development of these tumours and delve more deeply into their therapeutic vulnerabilities.

Part of the research is aimed at developing a new prognostic «biomarker» — proteins present in the cancer that identify TNBC patients at high risk of metastasis (development of secondary tumours).

Jessica Zucman - Rossi and her colleagues have shown that AAV2 leads to excessive expression of these genes which, according to the researchers, may favour tumour development.

Understanding the processes that restrain mutant cells from developing into tumours, and how they are breached when cancers do form will guide the development of strategies to reduce the chance of cancer development in individuals who have acquired a high level of mutations.

In this study the researchers achieved reprogramming of adult cells without the use of a gene which has been linked to the development of tumours.

Clinicians and investigators in the fields of veterinary and human endocrine oncology, clinical trials, pathology, and drug development will be joined in this consortium, in order to improve knowledge, development of, and access to naturally occurring canine endocrine tumours, as a model for human disease.

Mutations in p53, BRCA1 and chromosome instability are frequently associated with ovarian tumour development, but little is know about the cytoskeleton organisation in this type of tumours.

No study contained data on the effect of quitting smoking on cancer specific mortality or on development of a second primary tumour in non-small cell lung cancer.

The studies reported in the present study demonstrate that Slc6a14 plays an important role in promoting the development and growth of PyMT - driven and Neu - driven mammary tumours in mice.

When components of the TGFβ signalling pathway, e.g. Smad 2 and / or 4 are mutated, cell proliferation is uncontrolled and can lead to the development of cancerous tumours.

Because SLC6A14 is essential for tumour growth yet dispensable for normal development and tissue maintenance, small molecules that block amino acid import through this transporter could be effective and selective anti-cancer agents, particularly as components of rational drug combinations.

(D) Deletion of Slc6a14 delays the development and growth of mammary tumours also in MMTV - Neu - Tg mice.

They are seeking a Scientific Officer 2 to jointly work within our Tissue Biomarkers Team and Tumour Immunology and Inflammation Monitoring Laboratory Team (TIIML) to assist in the development and implementation of tissue biomarkers to monitor immune status and responses.

However, when crossed with PyMT - Tg mice or MMTV / Neu (mouse mammary tumour virus promoter - Neu)- Tg mice, the development and progression of breast cancer were markedly decreased on Slc6a14 − / − background.

Non-functional tumour suppressors or activated oncogenes can cause the development of cancer.

In contrast, no Slc6a14 − / − female with PyMT transgene developed tumours at 3 months of age; however, at 4 months of age, small tumour nodules became detectable (Figure 2B), indicating a marked delay in mammary tumour development in PyMT - Tg mice as a consequence of Slc6a14 deletion.

We have a range of opportunities, including funding, events and career development support, to help researchers develop their focus on brain tumours.

In previous research, the researchers discovered that freeze - dried strawberries inhibited the development of tumours in the oesophagus of rats.

The rats were exposed to 1 of the chemicals utilized in the most commonly used HRTs in the US — a progestin known as MPA (medroxyprogesterone acetate), which is also the very same synthetic hormone which accelerates development of breast tumours.

The research is the 1st to make a comparison between the cancer - fighting potency of marine versus plant - derived omega - 3s on cancer tumour development.

The study revealed that marine - derived omega - 3s are 8 times more effective for the inhibition of tumour growth and development.

Some synthetic hormones made use of in HRT accelerate development of breast tumours.

Apigenin stopped formation of new blood vessels, thus delaying, and at times blocking, tumour development.