Sentences with phrase «of tumour samples»

Several studies have demonstrated the feasibility of molecular screening of tumour samples for matching patients with cancer to targeted therapies.

There is substantial clinical impact of performing genetic profiling of tumour samples in order to identify specific mutations and match those mutations with targeted therapies; one of the earliest forms of «personalised» or «precision» medicine.

Not exact matches

The team found that exposing samples of human glioblastoma tumours grown in a dish to the Zika virus destroyed the cancer stem cells.

Scientists at The Institute of Cancer Research, London, analysed 177 tumour samples from patients with stage I non-seminomatous tumours enrolled in clinical trials through the Medical Research Council (MRC) Clinical Trials Unit.

In each person, the team found more than 100 mutations in the various tumour samples analysed; only about one - third of them occurred in all samples.

It will soon be time to take samples of the 3 cm invisible tumour hidden in the patient's left lung.

Nearly all cancers are still diagnosed by doctors taking a sample of the tumour, a so - called biopsy, then slicing it thinly and staining it with two vegetable dyes used for more than 100 years.

However, biopsies are prone to sampling errors and so may not be representative of the tumour as a whole.

In research funded by Sparks charity, Great Ormond Street Hospital Children's Charity and Cancer Research UK, researchers at the University of Cambridge have developed a test for blood and cerebrospinal fluid samples that looks for a specific panel of four pieces of short genetic code known as microRNAs, which are found in greater quantities in malignant germ cell tumours.

Thanks to our surgeons, we were able to obtain samples along normal - looking ducts close to the nipple and close to the tumour, as well as samples on the opposite side of the same breast to study and compare.»

«We therefore looked for patient characteristics that would account for this result; next generation sequencing (NGS) of the genes of interest was performed on the archival tissue samples from the patients» primary tumours,» explained Ciardiello.

In a study of 40 patients with high grade serous ovarian cancer, the researchers monitored tumour DNA that could be detected in a blood sample taken before each chemotherapy treatment.

The research team with international collaborators analysed more than 100 patient samples from ovarian and other cancer types to discover a distinct population of cells found in some tumours.

Prostate cancer researchers have mapped the impact of an acquired mutation that alters epigenetic identity, the make - up of DNA, in about 50 % of patient tumour samples.

This is in part due to the difficulty in acquiring samples of tumours that have spread to other tissues.

The team analysed levels of PTEN in around 500 ovarian tumour samples.

Samples of tumours from bowel cancer patients given different doses of resveratrol showed that even lower doses can get into cancer cells and potentially affect processes involved in tumour growth.

To do this, they switched from using dead tumour cell samples to patient - derived tumour cell lines, in which fresh samples of a person's tumour are grafted onto mice and grown to the required volumes.

In lab experiments, the research team used cell lines derived from 40 patient tumour samples to identify that CD151 contributes to the survival of cells of high - grade serous ovarian cancer origin.

The authors of the work also show that NANOG is increased in patient - derived tumour samples from stratified epithelia.

In collaboration with Dr Gabriele Bonatz from the Augusta clinics in Bochum (Brustzentrum), Hatt's team confirmed the existence of TRPV1 in tumour cells in nine different samples from patients suffering from breast cancer.

The outcome was the same; but Colletta's group could compare samples of tumours from women who had been taking tamoxifen with those who had never taken the drug.

These samples are then transferred to a mass spectrometer, which compares the combination of biomolecules with reference data collected from tumours and healthy tissue.

The method has been tested on many thousands of samples where the primary tumour was already identified, and it has proven extremely precise.

Oncologists were then required to obtain government approval before sending tumour samples out of the country for testing.

Doctors will take blood samples and tumour biopsies at intervals up to two months after the injection of TILs.

Carried out in cells in the laboratory, in mice and in samples from patients» tumours, the researchers showed this «safe haven» lets melanoma cells turn on a parallel set of cell signals that helps them survive.

By conducting an RNA - sequencing experiment of 103 matched tumour and normal colon mucosa samples from Danish CRC patients, 90 of which were germline - genotyped, researchers from the collaborative European project SYSCOL show that both inherited and acquired mutations in non-coding regions of the genome also contribute to cancer development and progression (Linda Koch, Nature Reviews Genetics).

The technique is insensitive to the level of mutated cancer cells in the sample, and the information about mutations can be linked directly to the way the tumour cells are growing in the tissue sample.

As part of this global aim we have demonstrated that one of the most abundant stromal populations, the cancer associated fibroblasts (CAFs), can sample and present tumour antigen to T cells in an antigen specific - antigen dependent manner resulting in T cell deletion.

Scientists looked at tumour samples and found that the drug penetrates the core of the tumour as well as the surrounding areas which contain smaller numbers of cancerous cells.

Clinical genomics involves the analysis of clinical tumour samples.

From the dogs» samples, researchers were able to prove that some cells in the vicinity of tumours act the same way as the cells would, in similar circumstances, behave in humans.

This may occur before surgery, if a small sample of dog tumour is collected.

When he commenced radiotherapy for treatment of the tumour in 2005 his consultant referred him to the Care Fertility Clinic in Northampton so that samples of his sperm could be taken and frozen for use in future reproduction.