Sentences with phrase «of tumour types»

Seen in this light, a variety of tumour types can originate from the same organ.

Not exact matches

A doctor exams mammograms, a special type of X-ray of the breasts, which is used to detect tumours as part of a regular cancer prevention medical check - up at a clinic in Nice, south eastern France January 4, 2008.

Molecular characterization of the cells that undergo cell fate transition upon oncogenic Pik3ca expression demonstrated a profound oncogene - induced reprogramming of these newly formed cells and identified gene expression signatures, characteristic of the different cell fate switches, which was predictive of the cancer cell of origin, tumour type and clinical outcomes in women with breast cancers.

«However, many patients do not respond because myeloid derived suppressor cells (MDSCs), a type of inhibitory cell, are present in the tumour microenvironment.»

The experimental drug nintedanib, combined with standard chemotherapy with paclitaxel, causes a total remission of tumours in 50 % of patients suffering from early HER - 2 - negative breast cancer, the most common type of breast cancer.

In future, levels of a modified protein present in many types of tumour may help predict whether it is likely to spread.

«The study of this type of tumours has been problematic up to now due to the lack of cell models and the appropriate animal models,» says CNIC researcher Juan Carlos Ramírez, who adds that the difficulty of generating these chromosomal translocations had limited the availability of cells with this mark of the disease.

A COMPOUND that slows the proliferation of triple - negative breast cancer cells in lab tests could lead to the first drugs to target this aggressive type of tumour.

«We could get some shrinkage of the tumours with other types of treatment we tried before, but we never got a complete cell kill,» he says.

Decitabine is approved by the U.S. Food and Drug Administration to treat myelodysplastic syndromes and leukemia, and for use in clinical trials for several types of solid - tumour cancers including colorectal.

Tumours which carry mutations in KRAS genes (40 % of CCR) or BRAF genes (between 5 and 15 % of these types of cancers) are ineffectively treated and have poor prognosis.

A non-invasive, low cost blood test that could help doctors diagnose some types of malignant childhood tumour has been developed by researchers at the University of Cambridge and Addenbrooke's Hospital, Cambridge University Health NHS Foundation Trust.

The researchers found five different sub-types of HL among the patients studied: 247 cases of the nodular sclerosis (NS) type, in which the tumour nodules are large; 105 of mixed cellularity, where a mixture of different types of inflammatory cells are involved; 58 lymphocyte rich, the sub-type with the best outcome; 68 «others»; and 143 «not otherwise specified» (NOS).

NGS was possible in 117 (76.5 %) patients and revealed that 66 patients had «all RAS» wild - type tumours with no mutations in KRAS; NRAS; BRAF; or PIK3CA genes and 51 patients had tumours harbouring a mutation in at least one of these genes.

Cancer stem cells are strongly associated with the growth and recurrence of all cancers and are especially difficult to eradicate with normal treatment, which also leads to tumours developing resistance to other types of therapy.

KRAS exon 2 mutations were found in approximately 15 % of the tumours that were originally identified as wild - type.

The team used five types of antibiotics — including one used to treat acne (doxycycline)-- on cell lines of eight different types of tumour and found that four of them eradicated the cancer stem cells in every test.

«Some of these genes were either increased or decreased in the area of the tumour, no matter the type of breast cancer, and this is important because within the patterns we identified were predictable alterations.

For the first time ever, we could make a really comprehensive comparison of individual normal and tumour cells from the exact same type of tissue, taken at the same time, from the same person, and see how the cancer had developed.»

This deadly type of lung tumour is almost exclusively linked to asbestos.

The research team with international collaborators analysed more than 100 patient samples from ovarian and other cancer types to discover a distinct population of cells found in some tumours.

The same approach may be useful for boosting the effects of chemotherapy in other types of solid tumour with high levels of stroma, Ganss says.

The use of whole genome sequencing enables researchers to accurately distinguish between tumour types with different treatment strategies.

The Harvard researchers have also implicated two cancer - causing viruses: human papilloma virus, which can cause cervical cancer, and Epstein - Barr virus, which infects about 95 per cent of people and has been linked to several types of tumour.

Another research goal is to find out whether the mutation leads to specific types of tumours or cancers that are triggered at a particular time of life.

The CNIO researchers show that cell defects caused by the inhibition of Cdh1 are independent of the presence of the p53 molecule, which is mutated in different types of tumours.

The team also found that there were also cases of other cancer types in families with these hereditary mutations such as leukemias and brain tumours.

While it is present on a number of different types of cells in the body, it is expressed at higher levels on metastatic tumour cells, including those which have spread from the lung.

Laboratory work has also shown that it strongly inhibits most types of epithelial tumour, including those of the breast.

Although most of the work has been carried out using in vivo studies, Asst Prof Gasser has been collaborating with Dr Joanne Ngeow at the National Cancer Centre Singapore to characterise the process in different types of human tumours.

It is known that a diet rich in fat can increase the risk of developing prostate cancer, and that obese people are more prone to develop this type of tumour.

They analysed about a million different cell mutations in more than 7,000 tumours from the Cancer Genome Atlas covering 24 types of cancer.

IBM's Watson, the supercomputer that famously won the TV quiz Jeopardy! in 2011, is analysing gene sequences from the most aggressive types of brain tumours.

The DNA of BKV has been discovered in several types of human cancers including prostate tumours, and mouse studies suggest the virus can trigger cancer.

One of the first treatments of this type, developed as early as 2004, specifically aims at slowing the growth of new blood vessels and at preventing neovascularisation of tumours.

Intriguingly, previous research found that RASAL2 was lost in some of the luminal type of breast tumours, where it acts as a tumour suppressor.

In recent years, researchers have discovered several ways of using genome sequencing of tumours to predict whether an individual cancer patient will benefit from a specific type of medicine.

TNBC is deadly because, unlike other types of breast cancers such as estrogen receptor (ER) positive or HER2 amplified breast tumours which have effective targeted therapy, TNBC tumours do not respond to targeted therapy.

With this finding, RASAL2 could be a new potential biomarker that is associated with the high risk of TNBC, rather than all types of breast tumours.

Hart and Vile hooked up the switch gene to the marker gene and injected the DNA directly into two types of mouse tumour.

In future, other switches could be identified in other types of tumour cell.

The team found that a type of bacteria called Bifidobacteria appeared to be related to a stronger immune response and slower tumour growth.

But not all types of tumours respond to these toxic compounds.

We believe that each dog breed may correspond to one type of B - or T - cell lymphoma and so studies within and between breeds gives us a unique possibility to understand how the genetic background affects what type of tumour develops, and how its progression is regulated», says Ingegerd Elvers.

The researchers found that weight is most closely linked to tumours that are «endocrine - receptor positive» - the most common type of breast cancer, affecting 75 per cent of patients.

AN insidious type of brain tumour cuts a swathe through the brain by secreting a compound that makes healthy neurons self - destruct.

So they then went on to study the genomes of a type of paediatric brain cancer characterised not only by a mutated polymerase — like in the tumours previously examined — but also by an inactivated repair system.

«While this has solved a long - standing scientific argument about which cell types can lead to invasive skin tumours, it is far more than just a piece of esoteric knowledge,» adds Professor Simons.

Researchers from Uppsala University, Sweden, and the Broad Institute, USA, have identified both similarities and differences between a single tumour type in multiple dogs breeds; a finding they believe parallels the situation in the cancer of human patients.

It recognises the four most common types of cancer — prostate, lung, colon and breast cancer — at a very early stage, namely when the level of calcium in the blood is elevated due to the developing tumour.