Sentences with phrase «of unaffected carriers»
Laws of population genetics predict that, on a purely theoretical ground, such a high number of genes should translate into an extremely elevated frequency of unaffected carriers of mutations.
http://www.completegenomics.com/ Not exact matches
Antonis C. Antoniou, Ph.D., of the University of Cambridge, England, and colleagues included 6,036 BRCA1 and 3,820 BRCA2 female carriers (5,046 unaffected and 4,810 with breast or ovarian cancer or both at study entry) in the analysis.
They predicted that unaffected mothers are «carriers» of devastating mutations that are preferentially transmitted to children affected with severe ASD.
Interestingly, the carrier - but - unaffected cases exhibit higher innate expression of wildtype PRPF31, likely a compensatory mechanism that prevents disease.
Risk - reducing surgery increases survival in BRCA1 / 2 mutation carriers unaffected at time of family referral.
With this type of disease, there are no unaffected «carrier» cats — all cats with an abnormal gene will be clinically affected.