Sentences with phrase «of uncertainty in the data»

We used methods that carefully consider potential sources of uncertainty in the data, including uncertainty in proxy calibration and in dating of the samples»

Even seemingly straightforward questions, for example «is X safe» and «is X not safe» seem like (effectively) asking the same question but they may require entirely different analysis and give different results — because of uncertainty in the data, in the results, the logical conclusions / inference required etc. etc..

In terms of remediation of the friction of scepticism in science, in recent years I have been stressing the proper, classic use of estimates of uncertainty in data, particularly one - sided bias mechanisms.

Just checking, but by implication you think the representation of the uncertainty in the data is appropriately represented here, using the standards applied in mainstream statistical inference?

Not exact matches

We are «concerned that these major findings are presented ambiguously within the Executive Summary and are inconsistent with the observations, data, and levels of uncertainty presented and discussed in the body of the draft Assessment Report,» states the review.

These risks and uncertainties include, among others: the unfavorable outcome of litigation, including so - called «Paragraph IV» litigation and other patent litigation, related to any of our products or products using our proprietary technologies, which may lead to competition from generic drug manufacturers; data from clinical trials may be interpreted by the FDA in different ways than we interpret it; the FDA may not agree with our regulatory approval strategies or components of our filings for our products, including our clinical trial designs, conduct and methodologies and, for ALKS 5461, evidence of efficacy and adequacy of bridging to buprenorphine; clinical development activities may not be completed on time or at all; the results of our clinical development activities may not be positive, or predictive of real - world results or of results in subsequent clinical trials; regulatory submissions may not occur or be submitted in a timely manner; the company and its licensees may not be able to continue to successfully commercialize their products; there may be a reduction in payment rate or reimbursement for the company's products or an increase in the company's financial obligations to governmental payers; the FDA or regulatory authorities outside the U.S. may make adverse decisions regarding the company's products; the company's products may prove difficult to manufacture, be precluded from commercialization by the proprietary rights of third parties, or have unintended side effects, adverse reactions or incidents of misuse; and those risks and uncertainties described under the heading «Risk Factors» in the company's most recent Annual Report on Form 10 - K and in subsequent filings made by the company with the U.S. Securities and Exchange Commission («SEC»), which are available on the SEC's website at www.sec.gov.

Actual results and the timing of events could differ materially from those anticipated in the forward - looking statements due to these risks and uncertainties as well as other factors, which include, without limitation: the uncertain timing of, and risks relating to, the executive search process; risks related to the potential failure of eptinezumab to demonstrate safety and efficacy in clinical testing; Alder's ability to conduct clinical trials and studies of eptinezumab sufficient to achieve a positive completion; the availability of data at the expected times; the clinical, therapeutic and commercial value of eptinezumab; risks and uncertainties related to regulatory application, review and approval processes and Alder's compliance with applicable legal and regulatory requirements; risks and uncertainties relating to the manufacture of eptinezumab; Alder's ability to obtain and protect intellectual property rights, and operate without infringing on the intellectual property rights of others; the uncertain timing and level of expenses associated with Alder's development and commercialization activities; the sufficiency of Alder's capital and other resources; market competition; changes in economic and business conditions; and other factors discussed under the caption «Risk Factors» in Alder's Annual Report on Form 10 - K for the fiscal year ended December 31, 2017, which was filed with the Securities and Exchange Commission (SEC) on February 26, 2018, and is available on the SEC's website at www.sec.gov.

The fact is that while your executives and managers may express interest in more data (more metrics, more dimensions, raw data access, more chart choices, etc.) this is an indicator of uncertainty, not of an interest to do more robust analysis.

The key uncertainty is how much the data has been distorted by the fall of China's annual Lunar New Year holidays, which were in February this year and in January in 2012 and which typically see factories shut up shop for two weeks.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

«In Canada as in the U.S. and Europe, the most common question investment consultants are asked by clients about ESG is whether an ESG - based approach will negatively impact investment performance,» said Andrew Sweeney, Institutional Portfolio Manager at RBC Global Asset Management Inc. «This and other data from the survey reveal a high level of interest and curiosity about responsible investing, including areas of significant uncertaintIn Canada as in the U.S. and Europe, the most common question investment consultants are asked by clients about ESG is whether an ESG - based approach will negatively impact investment performance,» said Andrew Sweeney, Institutional Portfolio Manager at RBC Global Asset Management Inc. «This and other data from the survey reveal a high level of interest and curiosity about responsible investing, including areas of significant uncertaintin the U.S. and Europe, the most common question investment consultants are asked by clients about ESG is whether an ESG - based approach will negatively impact investment performance,» said Andrew Sweeney, Institutional Portfolio Manager at RBC Global Asset Management Inc. «This and other data from the survey reveal a high level of interest and curiosity about responsible investing, including areas of significant uncertainty.

While the volatility follows a spate of weak economic data, it also reflects a broader uncertainty in the market.

We expect the Fed to raise rates just once this year — likely in December — and to proceed cautiously given the unevenness of the domestic economic recovery, as highlighted by weak retail sales data released last week, and global growth uncertainties.

Despite the backdrop of political and economic uncertainty, OPEC said that it anticipated world oil demand growth in 2016 to increase by 1.23 million barrels a day (mb / d) after a marginal upward revision, mainly to reflect better - than - expected economic data for the first half of the year.

But new data released by a group of U.S. - based economists suggests that for all of Donald Trump's day - to - day unpredictability in the U.S., economic uncertainty in Canada is far more extreme.

Q: Against the backdrop of political uncertainty, some economic data in Europe, especially in Germany, has softened a bit in recent weeks.

This uncertainty should gradually decline — for better or for worse — over the coming months, as the sequester's impact takes hold and more economic data come in, giving us a clearer picture of the forward momentum of the economy.

It is no different this time around except that in the environment characterized by fear, uncertainty, and doubt (FUD) that's prevailed since the 2008 Financial Panic, each instance of ebbing in data is feared to be the start of the next economic and market meltdown.

Carney, a former Bank of Canada governor, told reporters the outcome of the Brexit negotiation is the most important factor determining the U.K.'s economic fate, but the uncertainty surrounding it is already showing up in the data.

Nonetheless, geopolitical risk does not disappear, nor do global linkages (note the strong pull of Chinese data and market moves of late, or the uncertainty surrounding US elections in November), so fundamentals may have to strengthen much more before the BOJ takes further easing off the table.

Initially, investors were skeptical about any further tightening of monetary policy in coming months, amid escalating tensions between North Korea and the United States, further soft inflation data and uncertainty about the potentially negative effects of hurricanes Harvey and Irma on the economy.

National data pointed to continued strength in the Spanish economy but a loss of momentum in France, as French consumers reined in their spending, probably due to political uncertainty in the run - up to the country's presidential election.

Examples of these risks, uncertainties and other factors include, but are not limited to the impact of: adverse general economic and related factors, such as fluctuating or increasing levels of unemployment, underemployment and the volatility of fuel prices, declines in the securities and real estate markets, and perceptions of these conditions that decrease the level of disposable income of consumers or consumer confidence; adverse events impacting the security of travel, such as terrorist acts, armed conflict and threats thereof, acts of piracy, and other international events; the risks and increased costs associated with operating internationally; our expansion into and investments in new markets; breaches in data security or other disturbances to our information technology and other networks; the spread of epidemics and viral outbreaks; adverse incidents involving cruise ships; changes in fuel prices and / or other cruise operating costs; any impairment of our tradenames or goodwill; our hedging strategies; our inability to obtain adequate insurance coverage; our substantial indebtedness, including the ability to raise additional capital to fund our operations, and to generate the necessary amount of cash to service our existing debt; restrictions in the agreements governing our indebtedness that limit our flexibility in operating our business; the significant portion of our assets pledged as collateral under our existing debt agreements and the ability of our creditors to accelerate the repayment of our indebtedness; volatility and disruptions in the global credit and financial markets, which may adversely affect our ability to borrow and could increase our counterparty credit risks, including those under our credit facilities, derivatives, contingent obligations, insurance contracts and new ship progress payment guarantees; fluctuations in foreign currency exchange rates; overcapacity in key markets or globally; our inability to recruit or retain qualified personnel or the loss of key personnel; future changes relating to how external distribution channels sell and market our cruises; our reliance on third parties to provide hotel management services to certain ships and certain other services; delays in our shipbuilding program and ship repairs, maintenance and refurbishments; future increases in the price of, or major changes or reduction in, commercial airline services; seasonal variations in passenger fare rates and occupancy levels at different times of the year; our ability to keep pace with developments in technology; amendments to our collective bargaining agreements for crew members and other employee relation issues; the continued availability of attractive port destinations; pending or threatened litigation, investigations and enforcement actions; changes involving the tax and environmental regulatory regimes in which we operate; and other factors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commission.

Such a notion as emergence, for example, which is closely allied with the principle of indeterminacy and uncertainty and which was later to develop in physics, actually assumed more credence in physics before it took root in biology and psychology; yet it has more significant implications for the data of the organic and social sciences than for physics.

Given the paucity of hard data on which to calculate probable costs and benefits, how can responsible decisions be made in the midst of this uncertainty?

But this reckoning is burdened with still another uncertainty, apart from the question whether the data in the Gospel of John reflect the correct chronology.

Bolland's team also found multiple examples of inconsistencies between and within trials, errors in reported data, misleading text, duplicated data and text as well as uncertainties about ethical oversight.

His role, specifically, is to determine how uncertainties in the data could affect the simulation of the photochemical processes occurring in Titan's atmosphere.

«The evolutionary consequences of climate change are one of our greatest areas of uncertainty because empirical data addressing this issue are extraordinarily rare; this study is a tremendous step forward in our understanding of how climate change can influence evolutionary process and ultimately species biodiversity,» said Ryan Kovach, a University of Montana study co-author.

Given the uncertainty of finding gravitational waves, Allen and his team in 2009 expanded the Einstein@Home program to search for binary pulsars by analyzing radio - wave data from the Arecibo Observatory in Puerto Rico.

According to CathPCI Registry data, opportunities exist to improve not only adherence to appropriate use criteria in patients without acute coronary syndrome (ACS) but potentially clarify areas of uncertainty.

The EPA's IG found (pdf) in 2014 «there was significant uncertainty in the study data,» meaning the EPA's assumptions on the amount of methane that spews from pipelines «may not be valid.»

This is intended to take account of some of the uncertainties inherent in data on whale populations, and requires only two kinds of data: current estimates and their statistical error; and historical details of catches.

The models take account of uncertainties in the quality of the fossil data and the reconstructed evolutionary tree, and the result was clear.

However, uncertainty in the data exposing a lack of scientific «proof» of safety can equally well be used as a lack of «proof» of harm.

However, there are large uncertainties in the estimate and it appears it is not compatible with the satellite «handshake» data transmitted from the aircraft, which is currently considered the most reliable source of information.

In addition, Erez Lieberman Aiden, the director of the Baylor College of Medicine Center for Genome Architecture, and his colleagues have recently cataloged DNA - DNA contacts in intact nuclei, rather than in DNA that previously had to be extracted from nuclei, a step that adds uncertainty to the datIn addition, Erez Lieberman Aiden, the director of the Baylor College of Medicine Center for Genome Architecture, and his colleagues have recently cataloged DNA - DNA contacts in intact nuclei, rather than in DNA that previously had to be extracted from nuclei, a step that adds uncertainty to the datin intact nuclei, rather than in DNA that previously had to be extracted from nuclei, a step that adds uncertainty to the datin DNA that previously had to be extracted from nuclei, a step that adds uncertainty to the data.

New research using data from NASA's Van Allen Probes mission helps resolve decades of scientific uncertainty over the origin of ultra-relativistic electrons in Earth's near space environment, and is likely to influence our understanding of planetary magnetospheres throughout the universe.

Co-author Dr Iain Staffell, from the Centre for Environmental Policy, said: «This tool allows us to combat one of the biggest uncertainties in the future energy system, and use real data to answer questions such as how electricity storage could revolutionise the electricity generation sector, or when high - capacity home storage batteries linked to personal solar panels might become cost - effective.»

In order to make this work, the authors describe necessary steps of a rigorous informed consent process that outlines the risks and uncertainties, close involvement of institutional review boards, and multicenter trials to collect data.

Now, it is apparent from reading even the first few pages of The Skeptical Environmentalist that Lomborg proposes to make the case that not just environmentalists, but a considerable part of the heretofore respectable environmental - science community, have been misunderstanding the relevant concepts, misrepresenting the relevant facts, understating the uncertainties, selecting data, and failing to acknowledge errors after these have been pointed out in other words, that the scientist contributors to what he calls «the environmental litany» (namely, that environmental problems are serious and becoming, in many instances more so) have been guilty of massively violating the scientists code of conduct.

The practice of science, which includes the packaging of findings from science for use in the public - policy arena, is governed by an unwritten code of conduct that includes such elements as mastering the relevant fundamental concepts before venturing into print in the professional or public arena, learning and observing proper practices for presenting ranges of respectable opinion and uncertainty, avoiding the selection of data to fit pre-conceived conclusions, reading the references one cites and representing their content accurately and fairly, and acknowledging and correcting the errors that have crept into ones work (some of which are, of course, inevitable) after they are discovered by oneself or by others.

However, sparse palaeoenvironmental data in key regions and uncertainties in climate simulations and in the dating of fossil and archaeological records have hindered progress in this field.

Our new -LCB- \ em Spitzer -RCB- observations were taken two years after the original K2 discovery data and have a significantly higher cadence, allowing us to derive improved estimates for this planet's radius, semi-major axis, and orbital period, which greatly reduce the uncertainty in the prediction of near future transit times for the -LCB- \ em James Webb Space Telescope -RCB--LRB--LCB- \ em JWST -RCB--RRB- observations.

The period where ARGO data makes up the bulk of data (2004 - 2008 in red) has a greater uncertainty only because their period of observation is much shorter (5 years), versus 11 years for the interval where XBT data predominates (1993 - 2003 in blue).

«It's time for U.S. policy - makers to reflect and decide whether the year - to - year uncertainty in National Institutes of Health budget and the proposed cuts are in our societal and national best interest,» says Bishr Omary, M.D., Ph.D., senior author of the new data - supported opinion piece and chief scientific officer of Michigan Medicine, U-M's academic medical center.

I am disturbed with the quoted uncertainty in the Schmittner paper, in light of the significant discrepancies between the sensitivity extracted from the ocean and the land data (their figure 3).

These involved calculating weights for the velocity time series from the measurement uncertainties and adjusting them in order to minimize the noise level of the combined data.

This could be because of the structural deficiency of the model, or because of errors in the data, but the (hard to characterise) uncertainty in the former is not being carried into final uncertainty estimate.

First, the quality of the data is important: whether it is the LGM temperature estimates, recent aerosol forcing trends, or mid-tropospheric humidity — underestimates in the uncertainty of these data will definitely bias the CS estimate.