The findings suggest that Cell Painting may provide researchers with an inexpensive, high - throughput means to understanding the functions
of uncharacterized genes — a category that currently includes more than 30 percent of the human genome.
Not exact matches
James Collins, a professor
of biomedical engineering at Boston University who was not associated with this research, says, «Efforts in synthetic biology to create complex
gene circuits are often hindered by unanticipated or
uncharacterized interactions between submodules
of the circuits.
They also suggest that «this strategy may facilitate control
of... viruses
uncharacterized at the molecular level, regardless
of their genome type or variations in
gene products.»
Though some
of the affected
genes have been identified, the physical manifestations
of these alterations remain largely
uncharacterized.
There is evidence that a substantial portion
of the
uncharacterized risk for breast cancer is genetic, and this has encouraged the search for additional breast cancer predisposition
genes.
Through systematic annotation
of the resulting movies, we developed a phenotypic profiling system, which shows high correlation with cellular processes and biochemical pathways, thus enabling us to predict new functions for previously
uncharacterized genes.
This observation suggests that the bulk
of genes involved in Nasonia immune response remain
uncharacterized, with the current study being the first identification
of additional candidate
genes for immunity based on functional response to infection.
University
of Michigan researchers have discovered a new cause
of congenital myopathy: a mutation in a previously
uncharacterized gene, according...
In some cases these seem to represent novel, previously
uncharacterized antimicrobial peptides, but many more
of these immune - inducible
genes are difficult to characterize in the absence
of detailed functional studies.