Structural genomics analysis
of uncharacterized protein families overrepresented in human gut...
Integrative bioinformatics for functional annotation
of uncharacterized proteins and target discovery
We build detailed 3D atomic models
of the uncharacterized proteins and their complexes to derive hypotheses that, in close collaboration with the experimentalists, help to predict and understand their function and networks.
Drawing conclusions from this large number of proteins analyzed we have put forward a scheme for systematic localization
of uncharacterized proteins, pointing at potential pitfalls of each method and when and how you need to complement the methods or use other methods», says Emma Lundberg.
Not exact matches
1) This study reveals a previously
uncharacterized role for RNA in beebread / pollen instead
of protein, sugar and hormone in royal jelly to influence caste differentiation.
«A huge fraction
of the human «proteome» remains
uncharacterized, and this paper shows how chemical approaches can be used to uncover
proteins of a given functionality that have eluded classification based on sequence or predicted structure,» said co-senior author Benjamin F. Cravatt, chair
of TSRI's Department
of Chemical Physiology.
This initial project focused on 50
uncharacterized proteins that, based on literature searches, showed some likelihood
of being associated with human disease.
In a recent paper in the Journal
of Biological Chemistry, Franziska Dierck
of the University Medical Center
of Schleswig - Holstein and colleagues write that they identified a previously
uncharacterized z - disc
protein named CEFIP upregulated in cardiomyopathy.