Chromatin modifiers control how DNA is organized inside a cell's nucleus, and they are mutated in the majority
of urothelial cancers.
I am a urologic oncologist and surgeon - scientist focused on using modern scientific tools to improve the management
of urothelial cancers of the bladder and upper tract.
Saying current noninvasive approaches for detection
of urothelial cancer are suboptimal, researchers wanted to develop a test for bladder and UTUC cancer that would allow it to be found sooner and cheaper than current methods using cytology, which is not particularly sensitive and does not do well in detecting low - grade bladder cancer or UTUC.
Not exact matches
Cytology detected upper tract
urothelial cancers in only 10 percent
of those patients.
Of 56 patients with upper tract urothelial cancer, 75 percent tested positive using UroSEEK, including 79 percent of those with noninvasive tumor
Of 56 patients with upper tract
urothelial cancer, 75 percent tested positive using UroSEEK, including 79 percent
of those with noninvasive tumor
of those with noninvasive tumors.
UroSEEK uses urine samples to seek out mutations in 11 genes or the presence
of abnormal numbers
of chromosomes that would indicate the presence
of DNA associated with bladder
cancer or upper tract
urothelial cancer (UTUC).
A Randomized, Double - Blinded, Phase II Study
of Maintenance Pembrolizumab versus Placebo after First - line Chemotherapy in Patients with Metastatic
Urothelial Cancer
April 4, 2016 Precision medicine brings new hope to those with advanced
urothelial cancer Five
of six patients with advanced metastatic
urothelial cancer and at least one
of two specific genetic abnormalities, responded to treatment with afatinib, which was approved in 2013 by the Food and Drug Administration for patients with lung
cancer, researchers report online in the Journal
of Clinical Oncology.
The relatively low incidence
of prostate
cancer in intact dogs may suggest that testicular hormones Page 4
of 12 are in fact protective against ductal /
urothelial prostatic carcinoma, or may have indirect effects on
cancer development by changing the environment in the prostate.»