Sentences with phrase «of uveal»

Possible disease include keratitis (inflammation of the covering over the cornea), episcleritis (nflammation of the episcleral tissue), uveitis inflammation of the uveal tract) and glaucoma (damange to the optic nerve due to high blood pressure in the eye).

While some cysts may result from abnormal contact between layers of the uveal epithelium, others are believed to be caused by inflammation inside the eye.

Uveitis is inflammation of the uveal tract, which is composed of the iris, ciliary body, and choroid (the vascular components inside the eye).

The significance of uveal cysts is still being investigated, but a relationship between the cysts and development of glaucoma has been documented.

Chaired by Prof. Dirk Schadendorf, talks covered topics which included: melanoma epidemiology in the in period since the start of the German National Skin Cancer screening programme (Dr Andreas Strang); an overview of melanoma therapies used in stage IV melanoma; adjuvant therapies and prognosis in stage III melanoma (Dr Lisa Zimmer); tumour heterogeneity, plasticity and resistance in melanoma (Alexander Roesch); epigenomics of normal and abnormal cell differentiation (Bernard Horsthermeke); and, genetics and epigenetics of uveal melanoma (Michael Zeschnigk).

Certain occupations: Observation studies have proposed that welders, farmers, fishermen, chemical workers, and laundry workers might have a higher risk of uveal melanoma.

[48] Mutations in GNAQ or GNA11 occur in the majority of uveal melanomas and drive oncogenesis via activation of the phospholipase C / protein kinase C (PKC), Rho / Rac, and Yes - associated protein pathways.

Targeted prevention of uveal melanoma is currently not possible, since the causes are not known yet.

The team analyzed 29 inherited genetic mutations previously linked with skin melanoma to determine if there was an associated risk of uveal melanoma.

Now our strong data shows the presence of novel genetic risk factors associated with this disease in a general population of uveal melanoma patients,» says Kirchhoff.

Researchers expect the data presented in this study to fuel the formation of large national and international research consortiums to conduct comprehensive, systematic analysis of inherited (germline) genome data in large cohorts of uveal melanoma patients.

Unlike other solid tumors, there has been limited progress in understanding the contribution of genetic risk factors to the development of uveal melanoma, researchers say, primarily due to the absence of comprehensive genetic data from patients as the large sample cohorts for this rare cancer type have not been available for research.

About 1,500 cases of uveal melanoma occur in the United States each year, usually among older adults.

Dr. Schwartz thinks that treatment of uveal melanoma will ultimately involve rational drug design and a combination of drugs, similar to the approach used to combat HIV infection.

In experiments with mice, the UC San Diego - led team showed that verteporfin also suppresses the growth of uveal melanoma tumors derived from human tumors.

In cases of uveal melanoma metastasis, patients typically succumb within two to eight months after diagnosis.

Not exact matches

Aura additionally announced today that the U.S. Food and Drug Administration (FDA) has granted AU - 011 fast track designation for the treatment of primary ocular melanoma, also known as uveal or choroidal melanoma.

Scientists have long suspected a genetic association with uveal melanoma because one of two gene mutations is present in approximately 70 percent of all tumors.

But uveal melanoma often spreads to the liver, and determining the metastatic status of the disease can be difficult.

Uveal collectively refers to parts of the eye, notably the iris, that contain pigment cells.

Research teams focused on both cutaneous and uveal melanoma are fast - tracking discoveries into the clinical setting, and bringing novel therapeutic options to patients in the Philadelphia region,» said Karen Knudsen, Director of the Sidney Kimmel Cancer Center.

Uveal melanoma does not respond to the drugs given to patients with melanoma on the skin; and, in fact, there is no drug approved specifically for treatment of the disease.

Though uveal melanoma is rare — there are only 2,500 cases diagnosed in the United States each year — about half of patients will develop metastatic disease, and survival for patients with advanced disease has held steady at nine months to a year for decades.

In the trial, researchers randomized 98 patients with metastatic uveal melanoma and administered selumetinib to 47, of which 81 percent had a Gnaq or Gna11 mutation.

Uveal melanoma is a cancer of the iris, ciliary body, or choroid — structures in the eye collectively known as the uvea.

Several years ago, researchers found that 80 percent of patients with uveal melanoma had mutations to GNAQ or GNA11, genes that activate signals in the mitogen - activated protein kinase (MAPK) pathway.

In one of the balancing acts of medicine, the anti-inflammatory action of the drug also increases the risk for other conditions, in this case, a rare form of eye cancer, uveal melanoma.

New research links specific inherited genetic differences (alterations) to an increased risk for eye (uveal) melanoma, a rare form of melanoma that arises from pigment cells that determine eye color.

«Genetic susceptibility to uveal melanoma has been traditionally thought to be restricted only to a small groups of patients with family history.

«But this data is also important because it indicates — for the first time — that there is a shared genetic susceptibility to both skin and uveal melanoma mediated by genetic determination of eye color.

NEW YORK, NY (June 19, 2014)-- For the first time, a therapy has been found that can delay progression of metastatic uveal melanoma, a rare and deadly form of melanoma of the eye.

The paper is titled, «Effects of Selumetinib vs. Chemotherapy on Progression - Free Survival in Uveal Melanoma.»

A Phase I / II, Open - label, Multi-center Study of the Safety and Efficacy of IMCgp100 using the Intra-patient Escalation Dosing Regimen in Patients with Advanced Uveal Melanoma

Current clinical trials include combination of intrahepatic embolization and a radiosensitizer in patients with uveal melanoma and liver - only metastases, a phase I trial that evaluates a combination therapy of BCG with ipilimumab in Stage III / IV melanoma, and several landmark international trials including a phase II trial that evaluates combination immunotherapy with nivolumab & ipilimumab.

«This is one of our major goals,» Sondek said, «to figure out how to inhibit that always - active Gα protein in uveal melanoma.»

More than one - third of patients with metastatic uveal melanoma had objective tumor regression when treated with adoptive transfer of autologous tumor - infiltrating lymphocytes.

The appearance of the moles and the melanomas in these families can be unusual and affected families are also at increased risk of other cancers such as mesothelioma and eye (uveal) melanoma.

The Department of Translational Research hosts 5 technological platforms (Genomics, Protein arrays, High - content screening, Experimental radiotherapy and Preclinical investigation), 4 labeled teams (resistance to therapy in breast cancers, translational pediatrics, angiogenesis, and immunotherapy) and 3 emergent teams (Circulating biomarkers, uveal melanoma, and new targets in triple negative breast cancers).

Analysis of cancers in the pedigree of the proband carrying the S98R variant and in two other pedigrees carrying clear loss - of - function alleles showed the presence of BAP1 - associated cancers such as renal cell carcinoma, mesothelioma and meningioma, but not uveal melanoma.

Germline mutation of the BRCA1 associated protein - 1 (BAP1) gene has been linked to uveal melanoma, mesothelioma, meningioma, renal cell carcinoma and basal cell carcinoma.

Uveal melanoma is a melanoma that occurs either in the coloured part of the eye (the iris) or other tissues nearby.

Uveitis is usually diagnosed following an examination of the ocular structures by your veterinarian or veterinary ophthalmologist utilizing instruments, which magnify and illuminate the uveal tract.

Uveitis is inflammation of the eye's uveal tract, which consists of the eye's vascular tissues.

Uveitis is an inflammation of the eye's uveal tract and glaucoma is a buildup of pressure in the eye damaging the optic nerve.

Therapies available to Hospital for Large Animals patients include laser therapy for uveal cysts, cyclosporine implants for equine recurrent uveitis, radiation and cryotherapy for different ocular cancers and state - of - the - art ocular ultrasound and ocular surgery.

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