Recombinant vaccines represent the very cutting edge
of vaccine technology in both veterinary and human medicine.
Because the H10N8 and H7N9 strains are not circulating in the general population where the trials are taking place (the U.S. and Germany), Moderna is able to study the efficacy
of its vaccine technology in naïve patient populations.
The HZI will provide expertise and technologies for adjuvants and the preclinical validation
of vaccine technologies and candidates in murine systems.
Not exact matches
«We are honored to receive this award which underscores the unique value
of our
technology platform and its game changing potential to make novel
vaccines for important human diseases.»
You not that «not many people think
of childhood
vaccines or pacemakers etc as unnatural or life extension
technology,» but they are!
Today, Cuba has a hardy biotechnology industry that exports a number
of important
vaccines, antibody - based drugs and other biomedical
technologies.
This
technology could help researchers rapidly generate new peptide drugs to test on a variety
of diseases, and it also raises the possibility
of easily producing customized cancer
vaccines for individual patients.
It's also a stark contrast to today's egg - based
technology, which takes about six months to produce a mere 100 million doses, according to Alan Shaw, CEO
of VaxInnate, a company at the forefront
of bacteria - based
vaccine production.
Poland reckons doctors will be able to use the
technology to predict whether a person is likely to respond to a
vaccine, or if they are at risk
of side effects.
VaxInnate is testing a universal flu
vaccine that would work against all strains
of the disease by using a Toll - like receptor (TLR)
technology platform.
To create a new dengue virus
vaccine, Stefan Metz, Shaomin Tian in the laboratories
of Aravinda de Silva, Chris Luft and Joe DeSimone at the University
of Carolina, Chapel Hill, USA designed nanoparticles
of various shapes and sizes using Particle Replication in Non-wetting Template (PRINT)
technology.
«However, the promising results
of this trial lay the foundations for the development
of a more cost - effective, clinically - practical
vaccine technology that could deliver similar outcomes for patients.
Phase II trials for that
vaccine candidate are set to begin within the next two months, so it will not likely be available to combat the current swine flu outbreak, which could kill as many as 90,000 Americans and land up to 1.8 million in the hospital, according to the President's Council
of Advisors on Science and
Technology (PCAST).
Other scientists add that it should force governments to rethink existing
vaccine technologies, which are only capable
of supplying
vaccine six months after a pandemic starts, and
of producing enough
vaccine for a small fraction
of the world population.
«This is a big deal,» says Nobel laureate David Baltimore, president
of the California Institute
of Technology and head
of a U.S. government advisory panel on AIDS
vaccines.
It exports a number
of vaccines, antibody - based drugs and other biomedical
technologies.
Moderna is a clinical stage pioneer
of messenger RNA (mRNA) therapeutics and
vaccines, an entirely new drug
technology that directs the body's cells to produce intracellular or secreted proteins.
Ingo Potrykus at the Swiss Federal Institute
of Technology is engineering a novel strain
of rice fortified with extra iron and vitamin A. Charles Arntzen, president
of the Boyce Thompson Institute for Plant Research at Cornell University, is working on perhaps the most ambitious genetically engineered food
of all: an edible
vaccine.
of the world since it began nearly three years ago, and he suggests a way to prevent similar disputes in the future: Developed countries should provide
technology transfer to help poor countries, allowing them to produce their own
vaccines.
Examples include changing policies to encourage older adults to remain part
of the workforce for longer (e.g., removing tax disincentives to work past retirement age), emphasising low - cost disease prevention and early detection rather than treatment (eg, reducing salt intake and increasing uptake
of vaccines), making better use
of technology (eg, mobile clinics for rural populations), and training health - care staff in the management
of multiple chronic conditions.
5) Explore new
vaccine technologies — Longer term, we need to evaluate new ways to vaccinate wild carnivores for distemper, in situations wherein use
of an injectable
vaccine is not feasible by hand or by dart.
Along with discussing the potential benefits — such as making seed
vaccines in a day and producing biofuels — some debated whether Venter's part - artificial bacterium is a major advance or simply an extension
of existing DNA
technologies.
Jury member Penny Heaton, director
of vaccine development at the Bill & Melinda Gates Foundation, said CureVac's RNA
technology had «the potential for a large and positive impact on public health,» in a statement released by the company on 10 March.
«Now I see how
vaccine technology can be used against a host
of public health issues.»
In November 2012, the company also showed, along with scientists from the Friedrich Loeffler Institute, that the
technology could lead to a new generation
of flu
vaccines.
With the completion
of the first phase
of the Human Genome Project in 2000, and the advent
of sequencing
technologies that can detect gene variations such as single nucleotide polymorphisms (SNPs), for the first time scientists have the tools in hand to find the key immune genes and genetic networks that play roles in
vaccine response.
The majority
of new drugs and
vaccines are developed within the private sector and they are developed as commercial goods so there is a lack
of a public mechanism to advance R&D
of new
technologies.
There are ongoing studies which focus on the discovery
of molecular biomarkers
of the VSV - ZEBOV
vaccine in healthy individuals using omics - based
technologies in combination with a systems biology approach,» says Ali Harandi.
Significantly, J&J's latest
vaccine uses so - called mosaic
technology to combine immune - stimulating proteins from different HIV strains, representing different types
of virus from around the world, which should produce a «global»
vaccine.
The winners
of the prize are Maged Al - Sherbiny from Egypt, for his research on
vaccines and diagnostics against hepatitis C and schistosomiasis; plant scientist Felix Dapare Dakora from Tshwane University
of Technology, Pretoria, in South Africa for his work on legumes and soil bacteria; and Rossana Arroyo
of the Centre for Research and Advanced Studies
of Mexico's National Polytechnic Institute, who studies trichomoniasis, a parasitic disease.
The 4 - year - old institute consists
of six core research areas focused on a wide range
of technologies, from cancer
vaccines to robotic bees that will pollinate plants.
The ability to design new protein nanostructures could have useful implications in targeted delivery
of drugs, in
vaccine development and in plasmonics — manipulating electromagnetic signals to guide light diffraction for information
technologies, energy production or other uses.
«This is an important demonstration
of the possibilities opened up for immunotherapy by DMAb
technology to direct in vivo production
of antibodies
of major relevance to human cancer,» said David B. Weiner, Ph.D., executive vice president
of The Wistar Institute, director
of The Wistar Institute
Vaccine & Immunotherapy Center, W.W. Smith Charitable Trust Professor in Cancer Research, and senior author
of the study.
VIP
technology bypasses the requirement
of the host to make its own immune response against malaria, which is what occurs with a
vaccine.
The trial is sponsored by Global Health Innovative
Technology Fund (Japan) and results
of vaccine efficacy will be available in late 2018.
The
vaccine technology clearly has a biological effect that prevents dengue,» says Derek Wallace, regional director
of clinical development for Sanofi Pasteur, the French pharmaceutical firm developing the
vaccine, who reported results online today at The Lancet.
Batista was one
of a number
of scientists involved in the study from the Ragon Institute, established in the Boston area by experts from Massachusetts General Hospital, Harvard University and the Massachusetts Institute
of Technology, with the goal
of working toward development
of an effective
vaccine against HIV / AIDS.
From that chat has arisen plans for the MSD Wellcome Trust Hilleman Laboratories — named after a
vaccine scientist who worked at Merck — a non-profit research institute that it will act like a nimble biotech company with «dynamic decision - making» in the words
of Ted Bianco, director
of technology transfer at the Wellcome Trust.
IDMIT will contribute 1) To the development and validation
of assays based on flow cytometry and mass cytometry for the evaluation
of immune responses in humans and animal models; these tools will be particularly relevant for the identification
of signatures
of vaccine efficacy; 2) To the animal model platform, in particularly by providing access to NHP models and to new
technologies for in vivo imaging infections and host responses; 3) To networking activities, in particular by organising a workshop on in vivo imaging.
These
technologies are particularly powerful when looking for changes in concentrations
of multiple targets under specific conditions, such as following a
vaccine administration, infection, or a drug treatment.
Innovative imaging
technologies to monitor responses to
vaccines and infections in suitable models will provide information in characterisation
of live
vaccine (such as BCG)
of its biodistribution and persistence.
The laboratory has also all
of the
technologies required to produce recombinant bacteria expressing
vaccine antigens to be used as non-pathogenic
vaccine vectors.
TRANSVAC will further accelerate
vaccine development by developing and applying cutting - edge
technologies to address critical issues in modern
vaccine development and thereby increase the quality
of services provided.
We share and transfer our knowledge and
technologies to partners worldwide, providing opportunities for contract research and out - licensing
of (in - house) developed
vaccine technologies.
Today UNIL - VFL provides access to adjuvants, adjuvant quality control
technology, adjuvant formulation expertise,
technology transfer, training, and bespoke adjuvant R&D services, allowing partners to gain optimal benefit from the use
of adjuvants and
vaccine formulation
technology.
Finally, the HZI will help develop in vivo imaging
technologies to characterize (i)
vaccine biodistribution and persistence, and (ii) cellular and molecular changes at the injection site and in draining lymphoid tissues, helping to refine the use
of animal models.
iBET's infrastructure comprises 16 laboratories fully equipped with state -
of - the - art
technology (70 m2 each), including a BSL2 laboratory for working with viruses; a GMP Analytical Services Unit certified by the INFARMED (the Portuguese medicines authority, EMA Portuguese branch) and by DGAV (the Portuguese veterinary authority) for quality control and batch release
of human and veterinary pharmaceuticals, biopharmaceuticals as well as experimental new drugs; a GMP Mass - Spectroscopy Unit that provides state -
of - the - art MS services to the scientific community and Industry; a 2600 m2 bio-pilot plant supporting production and purification
of proteins ATMPs and
vaccines from bench top to 300 L scale and privileged access to GeniBET Biopharmaceuticals, an iBET spin - off producing ATMPs under cGMP certification for phase I / II / III clinical trials.
Through strategic partnerships with industry and nonprofit organizations, we gain access to a portfolio
of priority drugs for testing within our expert focus groups, including checkpoint inhibitors, therapeutic
vaccines, innate immune stimulants, targeted therapies, and many other promising treatments and
technologies with high therapeutic potential.
The module «Assay Development and Validation» will provide an insight into «state
of the art» applications
of SPR -
technology in the context
of vaccine development.
We use our mammalian expression
technologies to create panels
of recombinant pathogen proteins that are then used to identify new subunit
vaccine targets for infectious diseases.