Sentences with phrase «of vaccinia»

Plasmid contains the vaccinia K1L gene and the HIV - 192UG 037.1 p55 (subtype A) gag gene under control of the vaccinia 40K promoter.

Late last week, FDA worked with the United States Attorney to ask a court to seize the components of a product that involved the use of vaccinia virus vaccine as part of a purported treatment for cancer that FDA believes created the potential for substantial risks to patients.

They have taken extensive precautions to prevent the spread of vaccinia to health care workers and other patients from the moment he arrived.

Over one month, 30 people with an advanced form of hepatocellular carcinoma — the most common type of liver cancer — received three doses of a genetically engineered version of the vaccinia virus.

Replication of vaccinia is the first step to killing cancer cells and shrinking tumors with this approach.

Not exact matches

However, smallpox and yellow fever vaccines increase the risk of infants developing vaccinia and encephalitis.

Lederman, who says he's «obsessed» with Jenner and has been working on a biography of the scientist for 20 years, is convinced that Jenner's original vaccine, now named vaccinia, was derived from a virus circulating in horses, not cows, as folklore has it.

In a conversation about one of Evan's earlier vaccinia papers, Lederman told Evans that he'd love to know whether horsepox still works as a vaccine, but that he had had trouble getting hold of the virus.

Protein chemist Michael Way, cell biologist Sally Cudmore, and their colleagues at the European Molecular Biology Laboratory in Heidelberg and at the Pasteur Institute in Paris have found that vaccinia — a virus used in smallpox vaccines — surfs through cells on piles of actin, one of the basic structural proteins in the cellular skeleton.

Today vaccines (vaccinia is Latin for «cowpox») of all forms save 3 million lives per year worldwide, and at a bargain price.

He wonders whether it's not vaccinia, the virus used to induce smallpox resistance, but some other component of the vaccine that's prompting inflammation, perhaps bovine cells from the manufacturing process.

Geoffrey Smith and his team of virologists at Imperial College London were curious about the vaccinia virus, and set up a video microscope to watch how the virus spreads through cells.

Similarly, the entry for vaccinia, and even an essay on virology (one of 124 «windows» reviews by luminaries in their fields), mention smallpox without saying that it has been eradicated — one of the greatest achievements of medical science.

When the team tried to clone the heavy chain - only antibodies from three llamas, they could not get a set that would bind well to the several biothreats they desired to test — among them ricin, cholera toxin and vaccinia (a surrogate of smallpox virus).

Using a light microscope, researchers at the Swiss Federal Institute of Technology in Zürich watched fluorescently tagged vaccinia virus — a more benign cousin of smallpox virus — migrate toward target cells.

Did you know, for example, that the vaccinia virus is a member of one of the largest and most complex of the vertebrate viruses?

While looking carefully at the areas of cell destruction induced by the viruses — called plaques — he and colleagues noticed that vaccinia spread four times faster than its replication cycle would allow.

Cell biologist Michael Way of the London Research Institute agrees that other viruses may also use the vaccinia infection strategy.

When other vaccinia viruses come knocking, long projections of another protein, actin, shoot out from the cell membrane, causing the virus to bounce off.

(D) The average number of somatic hypermutations in the pandemic H1N1 patient plasmablast variable region genes compared with primary IgG plasmablast responses to vaccinia (small pox) or the anthrax vaccine, or after at least 4 boosters with the anthrax vaccine.

[3] Odunsi K, Matsuzaki J, Karbach J, Neumann A, Mhawech - Fauceglia P, Miller A, Beck A, Morrison CD, Ritter G, Godoy H, Lele S, duPont N, Edwards R, Shrikant P, Old LJ, Gnjatic S, Jäger E. Efficacy of vaccination with recombinant vaccinia and fowlpox vectors expressing NY - ESO - 1 antigen in ovarian cancer and melanoma patients.

On March 3, 2007, a two - year - old boy suffering from severe eczema and an unusual, widespread rash was transferred from St. Catherine's Hospital, in East Chicago, IN, to the University of Chicago's Comer Children's Hospital where he was diagnosed with eczema vaccinatum — a rare, severe, adverse reaction to the vaccinia virus.

Differences and similarities in viral life cycle progression and host cell physiology after infection of human dendritic cells with modified vaccinia virus Ankara and vaccinia virus.

The vaccinia virus 13L early / intermediate promoter is cloned upstream of the nef coding sequences.

Cytokine milieu of atopic dermatitis skin subverts the innate immune response to vaccinia virus.

The Pexa - Vec virus was originally developed by Michael Mastrangelo, MD, and Edmund Lattime, PhD, of Thomas Jefferson University in Philadelphia, who engineered the harmless vaccinia virus to infect only cancer cells and other rapidly dividing cells, as well as to stimulate immune activity, in hopes of boosting the immune response to tumors.

In another report, vaccinia was used as a vector vaccine for immunizing Balb / c mice with each of the SARS - CoV structural proteins (N, S, membrane, and envelope) and then challenged with SARS - CoV [21].

While at UConn, he researched improvements to the system for generating recombinant vaccinia viruses in the laboratory of Dr. Paulo Verardi.

Odunsi K, Matsuzaki J, Karbach J, Neumann A, Mhawech - Fauceglia P, Miller A, Beck A, Morrison CD, Ritter G, Godoy H, Lele S, Dupont N, Edwards R, Shrikant P, Old LJ, Gnjatic S, Jager E. (2012) Efficacy of vaccination with recombinant vaccinia and fowlpox vectors expressing NY - ESO - 1 antigen in ovarian cancer and melanoma patients.

To do this, a team led by Matthew Weitzman of the University of Pennsylvania crosslinked the host factors of infected human cells with the DNA of adenovirus, herpes simplex virus and vaccinia virus.

Agricola J, Munseri PJ, Nilsson C, Bakari M, Aboud S, Lyamuya EF, Tecleab T, Liakina V, Scarlatti G, Robb, ML, Earl PL, Moss B, Wahren B, Mhalu F, Ferrari G, Sandstrom E, Biberfeld G. Three - year durability of immune responses induced by HIV - DNA and HIV - modified vaccinia virus Ankara and effect of a late HIV - MVA boost in Tanzanian volunteers.

Elucidating the essential role of the A14 phosphoprotein in vaccinia virus morphogenesis: construction and characterization of a Tetracycline - inducible recombinant.

Temperature - sensitive mutants with lesions in the vaccinia virus F10 kinase undergo arrest at the earliest stage of virion morphogenesis.