This happens because the loss of blood flow in a vessel causes the local oxygen level to drop, which stimulates local
production of vascular endothelial growth factor, or VEGF, a protein which in most tissues causes the growth of new blood vessels to repair damage.
Vikas Gulati, MD Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, Nebraska Funding provided by a grant from The Alcon Foundation Project:
Effect of Vascular Endothelial Growth Factor Blockers on Aqueous Humor Dynamics
The pioneering work of Dr. Aiello helped demonstrate the
role of vascular endothelial growth factor (VEGF) in diabetic retinopathy and other retinal disorders, as well as the therapeutic potential of VEGF inhibitors in these conditions.
This happens because the loss of blood flow in a blood vessel causes the local oxygen level to drop, which stimulates local
production of vascular endothelial growth factor, or VEGF, a protein that in most tissues causes the growth of new blood vessels to repair damage.
They discovered that the placentas of preeclampsia patients showed more activity in the gene for sFlt1, a protein that blocks the
effects of vascular endothelial growth factor and placental growth factor, two key proteins necessary for an adequate placental development and normal blood vessel health.
From these cell based and clinical studies, we have developed important mechanistic ideas such as activation of protein kinase C, the
role of vascular endothelial growth factor (VEGF) and selective insulin resistance as some of the basic mechanisms for the pathogenesis of diabetic microvascular and cardiovascular diseases which are now widely studied by multiple laboratories.
-- Naringin is an inhibitor
of vascular endothelial growth factor (VEGF) release, which causes angiogenesis (formation of new blood vessels)(4).