«Their fangs evolved to be like hole - punchers,» says Bryan Fry, head
of the venom evolution lab at the University of Queensland in Brisbane.
«It had not particularly occurred to me as a likely mechanism
of venom evolution,» admitted Wolfgang Wüster, a lecturer at Bangor University.
«Understanding the dynamics
of venom evolution will help us refine not only our searches for new drugs and therapies, but also our understanding of how evolution generates chemical novelties,» Binford says.
«So we have a new addition to the theory
of venom evolution; that when the target itself is under extreme negative selection pressure against change, then the toxins themselves are under similar such pressure.
Bryan Fry, head
of the Venom Evolution Laboratory at the University of Queensland, generally agreed with that view in comments emailed to Quanta.
The findings enable the postulation of a new theory
of venom evolution.
The proposed «two - speed» mode
of venom evolution highlights the fascinating evolutionary dynamics of this complex biochemical cocktail, by showing for the first time the significant roles played by different forces of natural selection in shaping animal venoms.
Not exact matches
Our study provides unique genome - wide perspectives on the adaptive
evolution of venom systems as well as protein
evolution in general.
Dr Nicholas Casewell said: «These are the first snake genomes to be sequenced and fully annotated and our results in relation to the king cobra provide a unique view
of the origin and
evolution of snake
venom, including revealing multiple genome - level adaptive responses to natural selection in this complex biological weapon system.
The results
of a large - scale survey
of venom variation in the two snake species, published January 8, 2015 in the journal Genetics, challenge common assumptions in
venom evolution research, provide crucial information for rattlesnake conservation, and will help coral snake antivenom development.
Researchers from LSTM, along with a team
of international biologists who have recently sequenced the genome
of the king cobra, say that their work reveals dynamic
evolution and adaptation in the snake
venom system, which seemingly occurs in response to an evolutionary arms race between venomous snakes and their prey.
In contrast to positive selection, the role
of purifying selection (also known as negative selection, which is the selective removal
of deleterious genetic changes from a population) has rarely been considered in
venom evolution.
According to Drs. Moran and Sunagar, «The «two - speed» mode
of evolution of animal
venoms involves an initial period
of expansion, resulting in the rapid diversification
of the
venom arsenal, followed by longer periods
of purifying selection that preserve the now potent toxin pharmacopeia.
This process was hypothesized to result from an evolutionary chemical arms race, in which the invention
of potent
venom in the predatory animals and the
evolution of venom resistance in their prey animals, exert reciprocal selection pressures.
The analyses are highlighting the tangled paths
of spider
evolution, bringing into focus the complexities
of spider silk and
venom, and suggesting molecular - based ways to study these animals» behaviors.
That surprisingly low number suggested the
evolution of new species was accompanied by rapid turnover
of the
venom genes, with old genes being abandoned and new ones with novel
venom functions suddenly arising.
«Exploring the
evolution of spider
venom to improve human health.»
The data being collected by Garb and Binford and their colleagues have the potential to increase our understanding
of the
evolution of spider
venom and contribute to the discovery
of new medicines, anti-venoms and insecticides.
It would be comforting to think that a few hundred million years
of evolution have put considerable distance between us and our insect kin, but only some
of us are immune to insect - killing
venoms.
«We only plan to produce a handful
of Venom GT's in 2016 as we are also preparing for our next
evolution, the
Venom F5», said Hennessey.