The researchers propose that adding insulin to the mix
of venom toxins enabled predatory cone snails to disable entire schools of swimming fish with hypoglycemic shock.
Not exact matches
A newly identified
toxin in the
venom of a tropical centipede helps the arthropod to overpower giant prey in about 30 seconds.
These adaptations include the massive and rapid expansion
of gene families that produce
venom toxins, providing the snake with a highly toxic protein mixture required to overcome a variety
of different prey and also circumvent any resistance to
venom that may have developed in such prey.
Venom from an eastern diamondback rattlesnake in the Everglades is distinct from the cocktail
of toxins delivered by the same species in the Florida panhandle area, some 500 miles away.
The diversification
of these
toxins correlates directly with their functional importance in prey capture, for example the most pathogenic king cobra
toxin family have undergone massive expansion, while, in contrast,
venom proteins with less important functions do not participate in the evolutionary arms race occurring between snakes and their prey.
Armed with the both the king cobra and Burmese python genome the team was able to show that, despite previous hypotheses that
venom genes evolve «early» in the lineage leading to snakes,
venom gene families do not duplicate early, in fact the study shows that the rapid and extensive expansion
of functionally important
venom toxin families is restricted to the venomous «advanced» snake lineage.
Ken Shea and colleagues at the University
of California, Irvine, used melittin, the
toxin in bee
venom, as the antigen (the substance triggering an immune reaction).
The researchers identified 5
toxins within the snake
venom and used a technique called SPOT - synthesis to identify the sections
of the
toxin (epitopes) that are recognized by coral snake antivenom antibodies.
Now, researchers report that they have devised nanoparticles that sop up a variety
of common
venom toxins in test tube studies, a key stride in coming up with the first ever broad - spectrum snake antivenom.
Later on, when the sea anemones grow big and become predators themselves, their
venom adapts to their new lifestyle by producing a different kind
of toxin, one best suited to catch small fish and shrimp.
According to Drs. Moran and Sunagar, «The «two - speed» mode
of evolution
of animal
venoms involves an initial period
of expansion, resulting in the rapid diversification
of the
venom arsenal, followed by longer periods
of purifying selection that preserve the now potent
toxin pharmacopeia.
Claudio Vita and his colleagues at the protein engineering department
of CEA, the French nuclear research agency in Gif - sur - Yvette, are using the
toxins found in scorpion
venom as a chemical scaffold to build novel proteins for use as drugs (Proceedings
of the National Academy
of Sciences, vol 92, p 6404).
The fact that
venoms are mixtures
of specifically targeted
toxins rather than single
toxins is exactly what makes them such rich sources
of potential drugs — that's all a drug is, really, a compound that has a desired effect on our bodies.
«So we have a new addition to the theory
of venom evolution; that when the target itself is under extreme negative selection pressure against change, then the
toxins themselves are under similar such pressure.
«These findings raise important questions relating to the processes that other venomous animals may have used to generate their
venom toxins,» wroteNicholas Casewell, senior lecturer and Wellcome Trust research fellow with the Alistair Reid Venom Research Unit at the Liverpool School of Tropical Medicine, in a summary dispatch published alongside the Current Biology p
venom toxins,» wroteNicholas Casewell, senior lecturer and Wellcome Trust research fellow with the Alistair Reid
Venom Research Unit at the Liverpool School of Tropical Medicine, in a summary dispatch published alongside the Current Biology p
Venom Research Unit at the Liverpool School
of Tropical Medicine, in a summary dispatch published alongside the Current Biology paper.
Black widow (Latrodectus mactans) The
venom of the black widow contains a nerve
toxin that produces excruciating pain throughout the body.
A new study by Rice University biophysicists offers the most comprehensive picture yet
of the molecular - level action
of melittin, the principal
toxin in bee
venom.
The insulin genes were more highly expressed in the
venom gland than genes for some
of the established
venom toxins.
Dr. Levy says that proper doses
of vitamin C can safely and effectively eliminate the threat
of all viruses — as well as
toxins from drug overdoses and even
venom from snake bites.