«A new regulator
of vesicle trafficking in plants: Choline transporter regulates ion homeostasis and plant growth and development.»
Not exact matches
Protein
trafficking from the endoplasmic reticulum (ER) to the Golgi apparatus involves specific uptake into coat protein complex II (COPII)-- coated
vesicles of secretory and
of vesicle targeting (v - SNARE) proteins.
25 October 2013: The 2013 Nobel Laureates who published in Science include, for Medicine, James E. Rothman, Randy W. Schekman and Thomas C. Südhof for their discoveries
of machinery regulating
vesicle traffic, a major transport system in our cells.
CTL1 mutation also altered the distribution
of ion transporters, which, combined with previous work localizing CTL1 to the trans - Golgi network, led the authors to investigate whether CTL1 played a direct role in
vesicle trafficking.
A protein that transports the simple chemical choline plays a major role in
vesicle trafficking, ion homeostasis, and growth and development in plants, according to two new studies publishing 28 December in the open - access journal PLOS Biology, by Dai - Yin Chao
of the Shanghai Institutes for Biological Sciences, China, and Sheng Luan
of the University
of California, Berkeley, USA, and co-workers.
CTL1 is also found in animal cells, Chao noted, and thus the study concluded that «characterizing CTL1 as a new regulator
of protein sorting may enable researchers to understand not only ion homeostasis in plants but
vesicle trafficking in general.»
Enrich points out that «in the cell, cholesterol controls the
trafficking of vesicles, which are responsible for transporting integrins to cell surface.
He is presently studying the role
of specific defects in apical
vesicle trafficking in the etiology
of neonatal diarrhea syndromes in human.
During a brief post-doctoral fellowship with Harvey Lodish at the Massachusetts Institute
of Technology Rothman learnt to work with viruses and cell - free systems — thus acquiring skills that would later prove invaluable for identifying molecules involved in
vesicle trafficking.
Vesicle Traffic Late in the Secretory Pathway Little is known about the mechanism
of sorting and packaging
of secretory proteins that transit from the Golgi complex to the cell surface.
Others including Randy Schekman had discovered NSF to be important for
vesicle trafficking and secretion in yeast, leading Rothman to argue that these proteins are involved in
vesicle fusion in every cell
of the animal kingdom — a universal mechanism for secretion.