Sentences with phrase «of vorinostat»

«We showed that a single dose of Vorinostat could expose the hidden virus several years ago, but it has taken two studies over the last five years to define the proper interval dosing strategy to use Vorinostat safely and effectively,» said Nancie Archin Ph.D., lead author of this study and an assistant professor in the Division of Infectious Diseases at UNC.

HBI — through their Translational Research Fund — is the primary sponsor of the vorinostat clinical trial, with supplementary funding from ACHRI.

This spring, a clinical trial will start at the Alberta Children's Hospital exploring the clinical efficacy of vorinostat in children who have failed to respond to current anti-seizure medications.

Fifty of the 61 participants completed the full 21 - day course of vorinostat.

Not exact matches

One of the more intriguing findings in the study was that increasing histone crotonylation works synergistically with other known anti-HIV latency molecules, such as the protein kinase C agonist PEP005 and the HDAC inhibitor vorinostat.

A phase I clinical trial conducted by investigators at the University of Texas San Antonio, showed that the combination of HCQ and the chemotherapy drug vorinostat in 27 patients with advanced solid tumors, including renal cell carcinoma and colon cancer, was clinically safe and inhibited autophagy.

He is now focusing on a far more potent HDAC inhibitor, a relatively untested drug called vorinostat that is currently used to treat a few rare types of cancer.

Vorinostat is currently approved by the U.S. Food and Drug Administration to treat certain types of cancer.

During a withdrawal period of 24 hours, one alcohol - exposed group was treated with an FDA - approved HDAC inhibitor called suberoylanilide hydroxamine (SAHA), also known as Vorinostat, followed by anxiety and epigenetic measures.

Five years ago, he enrolled in a study at the UNC School of Medicine, which was part of Dr. David Margolis» «kick and kill» strategy for eradicating HIV by flushing it out of hiding with a drug called Vorinostat and killing it with either a vaccine

Using cancer drug vorinostat, Kennedy believes he can boost the one working copy of TCF4 to compensate for the damaged copy — like turning up the radio when it has one broken speaker.

Vorinostat interferes with the signaling transduction pathway of T - cell receptor and synergizes with phosphoinositide - 3 kinase inhibitors in cutaneous T - cell lymphoma

Romidepsin (Istodax) and vorinostat (Zolinza) inhibit enzymes called histone deacetylases (HDACs) that tighten the coil around DNA and block expression of tumor suppressor genes.

The team believes pairing a latency reversing agent, like Vorinostat, with an antiviral immune therapy, such as a vaccine or an antibody capable of recognizing and clearing the latent cells, will be needed to achieve a cure.

Combined autophagy and HDAC inhibition: a phase I safety, tolerability, pharmacokinetic, and pharmacodynamic analysis of hydroxychloroquine in combination with the HDAC inhibitor vorinostat in patients with advanced solid tumors.