Sentences with phrase «of vulnerable cell»

By understanding how certain brain cells are either vulnerable or resistant to neurodegenerative diseases, the lab has also discovered specific «profiles» of vulnerable cell types, thus advancing neuroprotective strategies for Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis (ALS).

Not exact matches

«We suspected that the young are most vulnerable because of their immature immune systems, but we didn't have a lot of hard evidence to show that before,» said study lead author Bo Hang, a Berkeley Lab staff scientist who previously found that thirdhand smoke could lead to genetic mutations in human cells.

Additionally, Belly Belly shared a baby's brain is extremely vulnerable to stress because cells are still moving where they need to be (migration) for the first year of life.

That's one of the reasons why inspectors praised the presence of telephones in cells, which allow «vulnerable boys to keep in touch with family and support networks».

And a new analysis of the STEP trial, published last November in Proceedings of the National Academy of Sciences USA, provides a warning that the very vectors (adenoviruses, which are also employed in other vaccine development work) used to distribute the inactive HIV strains can actually make the immune system more vulnerable to infection by recruiting susceptible T cells to mucous membranes, where they are more likely to be infected during sexual activity.

RARE but pernicious cancer «stem» cells, blamed for the spread and invincibility of some tumours, may be more vulnerable than we thought.

One of the cell lines was vulnerable to being cut off from glucose alone, but the others needed more interference.

In a continuation of this work, Goldman is also using mathematical modeling to pursue the most effective dose of chemotherapy to induce the vulnerable transition state of the cancer cell demonstrated in this research.

Among the compounds most vulnerable to attack by free radicals are the polyunsaturated fatty acids (PUFAs) vital to the structure and function of cell membranes.

«This is a first step,» he says, because it provides a target for therapy: somehow stimulating the SVZ to start replenishing the pool of cells that give rise to the vulnerable, depleted interneurons in CHD.

Thus, Tomasetti and Vogelstein reasoned, the tissues that host the greatest number of stem cell divisions are those most vulnerable to cancer.

The finding identifies how vulnerable cell groups react and respond differently to the accumulation of mitochondrial DNA damage seen in the disease, highlighting the need for cell - specific treatments.

The new study revives suspicions that adenoviruses cause an immune «own goal», priming people's immune systems to produce CD4 cells — the very cells that HIV prefers to infect — and, worse still, to direct those cells to the parts of the body that are most vulnerable to the virus during sex.

Although that marker, called IL21, had not previously been associated with autoimmune diseases, the gene that produces it sits right in the stretch of DNA known to make these mice vulnerable to diabetes, suggesting that IL21 might make a drug target, says Sarvetnick.Furthermore, by giving the animals a shot of dead bacteria — similar to an immunization in humans — when they were newborns, Sarvetnick and her colleagues prevented a surfeit of CD4 + and CD8 + cells.

Loss - and gain - of - function assays confirmed that cells with loss of KDM6A are vulnerable to EZH2.

A team at the University of Missouri Bond Life Sciences Center collaborated with scientists at the University of Bonn in Germany to discover genetic evidence that the parasite uses its own version of a key plant hormone and that of the plants to make root cells vulnerable to feeding.

These vulnerable patients, whose immune defenses have taken a dramatic double hit from both their original disease and the treatments required to repopulate their immune system with donor cells, are especially susceptible to a wide range of infections that typically don't cause major problems in healthy people.

The sneaky germ uses a mechanism like that of white blood cells to reach vulnerable tissues and hide from antibiotics

According to University of Helsinki scientist and Finnish Academy Research Fellow Juha Klefström, PhD, who led the study, «Myc oncoprotein not only boosts tumor cell proliferation but it also makes the cells vulnerable to cell suicide program, apoptosis.

Gradual increase of p53 levels activates apoptosis promoting protein Bak on the surface of the mitochondria making these cells vulnerable to death.

Jessica Hamzelou reports that 80 per cent of older people's brain cells are vulnerable to developing DNA damage (29 September,...

The inability of Myc transformed cells to rest and recover could explain why Myc makes cells so vulnerable to apoptosis.»

This reliance could make the cells vulnerable to disruption of the mitochondria.

«Secondary benefits of this trial include the significant improvement in clinical care for children with sickle cell disease at each of the 29 sites because each location had a designated hematologist, neurologist, neuroradiologist and psychologist working as a team to identify and decrease further injury to the brain in this vulnerable population.»

An experimental drug that targets abnormally high levels of a protein linked to cancer growth appears to significantly reduce the proliferation of prostate cancer cells in laboratory cell cultures and animals, while also making these cells considerably more vulnerable to radiation, according to results of a study led by Johns Hopkins scientists.

If a woman has an abortion, she's left with a large number of these immature cells lining her breast ducts, and she is therefore more vulnerable to cancer down the road — 30 percent more vulnerable, Brind says, than a woman who has never had an abortion.

Wilson says the process traditionally has taken so long that by the time enough new B cells were generated, the flu strain targeted already had mutated into a form no longer vulnerable to the captured crop of antibodies.

Cardiovascular disease in these young patients develops as vulnerable cells lining the interior of major arteries (vessels that carry blood away from the heart) accumulate the toxic protein and die.

Lack of dystrophin makes the muscle cell plasma membrane more vulnerable to injury.

Taking a closer look at the groups of vulnerable motor neurons, the researchers found differences in MMP - 9 expression at the single - cell level.

That could put stress on cells with weakened mitochondria, making them vulnerable to degenerative diseases such as Alzheimer's, geneticist Peter Larsen of Duke University and colleagues proposed February 24 in Alzheimer's & Dementia.

Circumcision is thought to prevent infection because the underside of the foreskin is rich in immune cells that are particularly vulnerable to HIV.

Instead of generating new cells as expected, they cause adult cells to protect vulnerable nerve tissue from inflammation

«If we can find out more information about why these subtypes of cells are protected, we may be able to use this information to tailor therapies to protect the vulnerable cells.»

In a separate set of experiments, Frank showed that the PcrV antibodies prevented the bacterium from shooting its toxin into cells, including macrophages, the immune system's scavenger cells, which are particularly vulnerable to Pseudomonas.

Long, thin fibers called axons extend from neural cells, and the particular geometry of the thalamus, with its many connections, makes it particularly vulnerable to injury.

The inability of cells to differentiate makes them vulnerable to genetic mistakes that drive cancer, since more «stemness» means a tendency toward rapid, abnormal growth seen in tumors.

Using specific, known types of cells allowed the researchers to see where the developing brain is most vulnerable, Song says.

The reason may be that their cells divide more times, increasing the chance of malignant mutation in ones that are especially vulnerable, such as cells in the skin.

Those are the cells that respond whenever the room gets dimmer or there are decrements in light; those are the ones that appear to be vulnerable at early stages of the disease and those are also the ones that are going to die first.

(14) The dopamine - producing cells of the SNc are particularly vulnerable to mutations in their mitochondrial genes, and a role for these mutations in PD is widely recognized.

In response, the cells underwent changes indicative of senescence, ceasing cell division and churning out key SASP factors.7 Notably, astrocytes were much more vulnerable to paraquat than skin cells: astrocytes went senescent at a lower concentration of the toxin than was required for skin cells, and the doses that turned skin cells senescent killed astrocytes outright.7

Honestly, no one is completely sure, but the vulnerable brain cells - called neurons - have a number of special features that might make them vulnerable.

Secondly, the secretory and other phenotypes of such cells progressively derange local and systemic metabolism and tissue function, rendering tissues more vulnerable to metastasis, promoting systemic inflammation, and otherwise impairing tissue function.

By identifying the critical genes and proteins that are targeted by both pathogens and disease - causing genetic mutations, he hopes to discover the vulnerable points in cells that can be targeted with drugs and potentially treat a multitude of diseases.

The cells that are most vulnerable to this process are muscle - related sensory neurons whose degeneration leads to the first symptoms of the disease.

These range from visual stimulation experiments that allow us to tap into the specific sets of retinal ganglion cells that are most vulnerable early in the disease, to the evolution of new imaging techniques, largely thanks to Alf Dubra and Vivek Srinivasan's work in those areas, and the ability to image retinal ganglion cells and their component parts like their axons which degenerate very early in glaucoma.

Since the goal of huntingtin lowering therapies like IONIS - HTTRx is to reduce the amount of the huntingtin protein in vulnerable brain cells, in theory this gives us a great way to tell whether the drug is doing what it's meant to do.

The most vulnerable cells in HD are brain cells called neurons, about half of the cells in the adult brain.

Larger numbers of senescent cells in a tissue make it more vulnerable to the spread of cancer, contribute to inflammation, and skew the local activity of the immune system.