Sentences with phrase «of white fat cells»

The «browning» of white fat cells is thought to be initiated by things like exercise, exposure to cold temperatures, and our sleep hormone melatonin.

A more recent study found that cold applied to human neck fat initiated the conversion [21] of white fat cells into brown ones.

Whitehead Institute researchers report that 10 long noncoding RNAs (lncRNAs) play a vital role in the regulation of white fat cells.

Furthermore, he demonstrated that a class of drugs often used in the treatment of diabetes also reduces the harmful effects of white fat cells on bones.

In their recent study, the UCSF team reports the discovery that a class of commonly prescribed Type - 2 diabetes drugs, called TZDs (thiazolidinediones, such as Actos and Avandia), promoted the conversion of white fat cells into brown (in mice and culture dishes) by stabilizing the PRDM16 protein.

As the researchers have shown in various studies on mice, the widespread active ingredient sildenafil or a medication against pulmonary hypertension, for instance, can be used to reduce the number of white fat cells to the benefit of the brown fat cells and thus accelerate fat burning like a turbocharger.

The study shows that activating the bile acid receptor TGR5 with molecules that mimic the action of bile acids (so called «mimetics») induces a remodeling of white fat cells into beige fat cells.

«The discovery of the «brite» fat cell mechanisms and the specific regulatory areas brings us closer to understanding how reprogramming of white fat cells takes place.

Not exact matches

In the study, mice were given food until they became obese, and were then fed the drug, which increases the cellular metabolism of obesity - linked white fat cells.

The seemingly more respectable Pharmacy News reported, «White tea contains catechins, which inhibit the process of fat cell generation by stimulating thermogenesis.

And it's a production powerhouse, full of life - giving stem cells — pumping out red blood cells, white blood cells, bone cells, and fat cells.

Colostrum consists of high concentrations of immunoglobulins, maternal antibodies that protect your baby's immune system, as well as white blood cells, water, protein, fat, minerals, vitamins and carbs.

Mature milk is comprised mostly of fat, water, carbohydrates, vitamins, protein, minerals, enzymes, amino acids and white blood cells.

The study, recently published in Cell Metabolism, also found that beige fat, unlike the better - known white and brown fat, has interesting anti-diabetic effects on blood sugar metabolism that seem independent of temperature regulation.

Some white fat cells are capable of transforming into a third kind of fat, beige.

In the laboratory, irisin and FGF21 turn human white fat cells into brown fat cells over a period of six days.

Other research groups are also generating promising results through the use of drugs to convert white fat cells into brown fat and through discoveries of the pathways and hormones that control brown fat metabolism.

Previous studies have found that brown fat can be coaxed into action by activating the β3 - adrenergic receptor, which is expressed on the surfaces of brown and white fat cells, as well as on cells of the urinary bladder and other tissues.

When exposed to cold, clusters of cells within the body's white fat become beige — a color change that reflects the creation of more energy - producing mitochondria, cellular components that enable cells to burn calories and give off heat.

The group is planning future studies that look at the effect of activating ERRγ in white fat cells — which they suspect could make some white fat resemble brown fat, and potentially help treat obesity and diabetes.

In the current study, Joslin scientists were interested in learning more about miRNAs and their role in the creation of fat cells and the function of brown and white fat.

In mice, this form of lipodystrophy was also characterized by «whitening» of brown fat cells, a loss of white fat, and signs of metabolic syndrome, including insulin resistance, fat tissue inflammation, dyslipidemia (elevated cholesterol and fat), increased resting energy use, and increased markers of cardiovascular disease.

Fat accelerates aging After examining 1,122 adult women, molecular biologist Tim Spector of St. Thomas» Hospital in London concluded that extra pounds can age white blood cells as much as 8.8 years.

The challenge is to reprogram the energy storing white fat cells into so - called «brite» (brown - in - white) fat cells in the body's white adipose tissue and thus make adipose tissue burn off excess energy as heat instead of storing it.

Now researchers from the University of Southern Denmark have uncovered the mechanism by which white fat cells from humans get reprogrammed to become browner.

The fact is that one of the key differences between «beige fat», which appears when administering melatonin, and «white fat», is that «beige fat» cell mitochondria express levels of UCP1 protein, responsible for burning calories and generating heat.

Researchers have turned their attention to these cells because some of the sugar and fat they burn is stored in the body and might otherwise lead to increases in white fat, the form that increases in obesity.

«What is exciting about our discovery is that low concentrations of TGR5 - selective molecules are sufficient to promote the beiging of white fat - storing cells, thereby bypassing the need to increase the total bile acid pool,» says Laura Velazquez, first - author of the paper.

The findings, published today in the journal Cell, give new insights into how the brain regulates body fat and may lead to more effective ways to lose weight and prevent obesity by promoting the conversion of white fat to brown fat.

There are three different types of fat cells: white fat cells, which store energy; brown fat cells, which expend energy; and the so - called «beige» fat cells, which are functionally related to brown cells while being located in typically white - fat depots.

In the new paper, Kajimura's team collaborated with the laboratory of Yasushi Ishihama, PhD, of the University of Kyoto, Japan, to search for differences in how white and brown fat cells respond to the cold using a technique called phosphoproteomics.

When they exposed these mice to the cold, the animals developed far fewer beige fat cells than did normal animals, suggesting that macrophages were key to browning of white fat.

The omentum's immune functions come from groups of small, white filters located among the fat cells.

Activating RXR triggered a cascade of changes in muscle precursor cells and white fat that ultimately converted them into brown fat - like cells.

Scientists at the University of Bonn have shown in mice that excess pounds can simply be melted away by converting unwanted white fat cells into energy - consuming brown slimming cells.

Prof. Dr. Alexander Pfeifer from the Institute of Pharmacology and Toxicology at the University of Bonn has spent years researching how harmful white fat cells can be converted into desirable brown fat cells.

The brown cells possess an extremely high number of mitochondria — these cell power stations «burn» white fat by converting it into thermal energy.

More beige fat cells and fewer white fat cells could reduce the symptoms or negative health outcomes of metabolic diseases like diabetes, obesity.

Now, however, a team of researchers led by Yu - Hua Tseng, Ph.D., Investigator in the Section on Integrative Physiology and Metabolism at Joslin Diabetes Center and an Associate Professor of Medicine at Harvard Medical School, has created cell lines of human brown and white fat precursor cells that will help investigators to pick apart the factors that drive the development and activity of each type of cell.

The scientists discovered that when cBAT is deficient, cBAT cells send a signal through the sympathetic nervous system to increase production of rBAT within white fat.

Detection of this CD29 marker eventually may help in selecting white fat precursor cells that can be transformed for obesity treatments, Dr. Tseng comments.

Using white fat tissue from liposuction or weight - loss surgery, «we might purify a population of these progenitor cells from an obese individual expressing C29 with high potential to become energy - dissipating cells,» she explains.

In analyses of the cell lines, precursor white fat cells from two subjects responded strongly to BMP7 but such cells from the other two subjects did not.

In one example, Dr. Tseng's group previously had shown that exposing precursor white fat cells to a protein known as BMP7 helps to spur the creation of brown fat cells.

Mice that received normal levels of prenatal vitamin A, from a regular diet, were born with more fat - loading white fat cells, fewer brown fat cells and fewer blood vessels.

The team says that this is a result of the oil triggering receptors in the digestive tract, activating the sympathetic nervous system and converting white fat cells into the beige variety.

It's secreted by the adipose tissue, largely, but also a number of other tissues have been shown to produce leptin, but the major source is the white adipose tissue which is basically fat cells.

Added to this is the fact that white fat also damages the hematopoietic stem cells of bone marrow which could results in reduced blood cell formation in bone with excess fatty infiltration.

December 21, 2016 — Noteworthy NIH advances in basic research include an expanded map of the human brain, nanoparticles that convert white fat to calorie - burning brown fat, and a 3 - D cell culture model of the placenta.

Unlike ubiquitous white fat cells, which lounge around storing fat, rarer brown ones burn fat at a higher rate as part of a duty to keep us warm.