Sentences with phrase «of whole human genomes»

A diverse data set of whole human genomes are freely available for public use to enhance any genomic study or evaluate Complete Genomics data results and file formats.

The advent of accessible and relatively inexpensive high - throughput sequencing technology has resulted in extensive sequencing of whole human genomes or exomes in a research setting and seems likely to lead to an explosion of genomic sequencing in a clinical context.

By overlaying that information onto a computer model of the whole human genome, they were able to identify key factors involved in cell regulation

«Taken together, the work represents a large step towards deciphering the code that controls gene expression, and provides an invaluable resource to scientists all over the world to further understand the function of the whole human genome», says Professor Taipale.

Complete Genomics provides free public access to a variety of whole human genome data sets generated from Complete Genomics» sequencing service.

Not exact matches

Moreover, data collected from whole - genome sequencing showed that Ata's molecular composition aligned with that of a human genome.

Using advanced sequencing technologies, University of Oklahoma anthropologists demonstrate that human DNA can be significantly enriched from dental calculus (calcified dental plaque) enabling the reconstruction of whole mitochondrial genomes for maternal ancestry analysis — an alternative to skeletal remains in ancient DNA investigations of human ancestry.

Human DNA can be significantly enriched from dental calculus (calcified dental plaque) enabling the reconstruction of whole mitochondrial genomes for maternal ancestry analysis — an alternative to skeletal remains in ancient DNA investigations of human anceHuman DNA can be significantly enriched from dental calculus (calcified dental plaque) enabling the reconstruction of whole mitochondrial genomes for maternal ancestry analysis — an alternative to skeletal remains in ancient DNA investigations of human ancehuman ancestry.

He founded a new company, Celera, and gambled on a «whole - genome shotgun assembly» approach, in which the 3 billion «letters» of human DNA would be fragmented, identified, and then put together in the correct order by computer.

But think of the Human Genome Project and how much it accelerated the process of discovery and the whole field when infrastructures existed for people to share and compare.

Whole genome sequencing of modern and ancient horses unveils the genes that have been selected by humans in the process of domestication through the latest 5,500 years, but also reveals the cost of this domestication.

In addition to Affymetrix, another California company, Agilent Technologies Inc. of Palo Alto (a sponsor of ScienceNOW), has begun distributing its own human genome array as an experimental prototype, and since June, NimbleGen Systems Inc. of Madison, Wisconsin, has been using yet another whole - genome setup to support a DNA - scanning service at a lab in Iceland.

Whole - genome studies of nearly 800 people from around the world show that all modern humans from outside Africa are descended from one group of migrants

The deCODE whole genomes study is «an amazing piece of work» that «was impossible 5 years ago,» says human geneticist Daniel MacArthur of Massachusetts General Hospital in Boston and the Broad Institute in Cambridge, Massachusetts, who was not involved in the research.

Since the introduction of high - throughput machines in the mid 2000s, costs have plummeted (above, orange) and the price of sequencing a whole human genome (above, gold) has tumbled almost to the long - anticipated figure of $ 1,000.

The high degree of similarity between the mouse and human genomes is demonstrated through analysis of the sequence of mouse chromosome 16 (Mmu 16), which was obtained as part of a whole - genome shotgun assembly of the mouse genome.

The human genome contains about 3 billion base pairs, but only about 2 percent of these base pairs represent protein - coding genes, meaning that whole - exome sequencing measures the genetic alterations focused on a small but very important fraction of the genome (as opposed to techniques of whole genome sequencing, which measures every nucleotide across the entire genome, regardless of whether these genes are expressed or silent).

Together with the French gene sequencing center Genoscope, in the Paris suburb of Evry, Celera will perform the initial sequencing using the «whole - genome shotgun» approach it unleashed on the human genome.

Using whole exome sequencing (a next generation test to analyze the exons or coding regions of thousands of genes simultaneously) conducted at the Baylor College of Medicine Human Genome Sequencing Center, the researchers identified CLP1 mutations in two unrelated families with the disorder.

Almost 10 years to the day after the human genome sequence was completed, a group of researchers has unveiled the first whole genome sequences of prostate tumors.

It was only by looking across the whole human genome that we were able to identify the function of P - TEFb in the immune system, offering potential new treatments for autoimmune conditions.»

Western Pygmies I love population genetics for its ability to peer back into human history through the medium of DNA's ATCGs.One of the stars of this discipline is Sarah Tishkoff, a standout in African genetics, someone who will readily haul a centrifuge into the bush in Cameroon.Tishkoff of the University of Pennsylvania is lead author on a paper published online July 26 in Cell that details whole - genome sequencing of five individuals each from three extant hunter - gatherer groups — the Pygmies of Cameroon as well as the Hadza and the Sandawe of Tanzania.

The study broke new ground in other areas as well, yielding the first ancient whole genomes of East Asian ancestry and the highest coverage ancient human genome from Asia (7x coverage) sequenced to date.

The significant overall sequence divergence of TMAdV from known human and simian adenoviruses is highlighted by the finding that PAdV - A (porcine adenovirus A), a non - primate mammalian adenovirus, shared only a slightly less similar whole - genome pairwise identity to TMAdV of 47.0 % (Fig. 4).

After removal of similar viral genomes, bootscan plots of the whole genome and individual genes from a subset representing human / simian adenoviruses in species A — G and all non-primate vertebrate adenoviruses were generated.

In these experiments, Berger and colleagues show that somatic PREX2 mutations identified through whole - genome sequencing of human melanoma can contribute to enhanced lethality of tumor xenografts in nude mice (Figure 3B, S6B, and S6C; Berger et al., 2012).

In 2012, as part of efforts to better understand the causes of melanoma, researchers at the Broad Institute, the Dana - Farber Cancer Institute and a number of other institutes reported the results of whole genome sequencing of 25 human metastatic melanomas (Berger et al., 2012).

The American Journal of Physical Anthropology published, «Successful enrichment and recovery of whole mitochondrial genomes from ancient human dental calculus,» in a recent issue.

NORMAN — Using advanced sequencing technologies, University of Oklahoma anthropologists demonstrate that human DNA can be significantly enriched from dental calculus (calcified dental plaque) enabling the reconstruction of whole mitochondrial genomes for maternal ancestry analysis — an alternative to skeletal remains in ancient DNA investigations of human ancestry.

Last year at around this time, they announced the HiSeq X Ten system, a «factory installation» for human whole genome sequencing (only) at an incredible scale: 18,000 genomes per year, at a cost of $ 1,000 each (for consumables).

The meeting covered everything involving birds: advances in food production, the study of evolution through whole genomes, how genes form tissues and organs, human medical developments, and transgenics.

The most significant of these was the HiSeq X Ten, a 10 - instrument «factory installation» that enabled the most cost - effective human whole genome sequencing to date: 18,000 genomes per year at a consumables cost of just over $ 1,000 each (note: this does not include the costs of data storage, analysis, or the $ 10 million buy - in).

I will review recent advances in the use of nanopore sequencing for clinical microbiology and human genetics, including our collaborations on viral and bacterial diagnostic sequencing, real - time surveillance, direct RNA and human whole - genome sequencing, and discuss the opportunities and barriers around moving to sequencing as a routine test in the clinic.

Gholson J. Lyon Biochemistry, amino - terminal acetylation of proteins, human genetics, neuropsychiatric diseases, whole genome sequencing

With new, faster computing tools to sequence cancer DNA, Vogelstein's team completed 88 of the first 100 whole exomic (that is, all the genes in the genome) sequences of human cancers.

This reference database will form the foundation for a national collaboration to share human whole genome data for the benefit of all scientists.

SweGen: a whole - genome data resource of genetic variability in a cross-section of the Swedish population, European Journal of Human Genetics advance online publication 23 August 2017; doi: 10.1038 / ejhg.2017.130

We focus on developing computational methods and tools for (a) analyzing large - scale gene expression data related to human cancer in search for gene markers and disease sub-categories, (b) identifying regulatory elements such as miRNA precursors and their targets in whole genomes of plants and mammals, (c) building theoretical models of gene regulatory networks.

The use of higher resolution techniques, such as array CGH and, soon, whole genome sequencing, will enhance the ability of researchers to examine stem cell lines to determine which are best — least likely to result in diseases and other problems — to use in creating therapies for use in humans.

Reference: September 13, 2007 issue of Cell Stem Cell under the title «Whole - Genome Mapping of Histone H3Lys4 and 27 Trimethylations Reveals Distinct Genomic Compartments in Human Embryonic Stem Cells».

To reconstruct modern human evolutionary history and identify loci that have shaped hunter - gatherer adaptation, we sequenced the whole genomes of five individuals in each of three different hunter - gatherer populations at > 60 × coverage: Pygmies from Cameroon and Khoesan - speaking Hadza and Sandawe from Tanzania.

As our understanding of the noncoding portion of the genome improves, it will become even more apparent that whole - genome sequencing (and not exome sequencing) will be required to characterize the full extent of phenotypically - relevant genetic variation in humans.

The project will sequence and analyse data of 10,000 new whole genomes across Europe in the next two years, further advancing the understanding of the human genome for the entire European population.

An open - source C / C + + library of analytical tools for human genetic variation data from whole - exome and whole - genome studies.

The projects focus on two areas: human whole genome sequencing to study the genetic basis of disease, and biodiversity.

«We are very pleased to be able to offer human whole genome sequencing of up to 15,000 individual genomes per year, enabling scientists to perform internationally competitive studies of human diseases and evolution» says Ann - Christine Syvänen at NGI in Uppsala.

Analyzes whole genome and detailed clinical data from nearly 300,000 Icelanders Finds several novel variations in the sequence of the human genome modulating cholesterol levels Five variants are also causally linked to increased risk of coronary artery disease Shows...

His laboratory has also discovered and characterized a significant number of novel genes contributing to autism and human neurodevelopmental disorders, and has recently applied whole - genome sequencing technologies and large - scale genomics datasets to prenatal detection and interpretation of structural variation in the genome.

The projects focus on two areas: whole genome human DNA sequencing to study the genetic basis of disease, and studies related to biodiversity.

REYKJAVIK, Iceland, 20 September 2017 — In a major study published today, researchers at deCODE genetics use whole - genome data from 14,000 people from across the population of Iceland, including 1500 sets of parents and children, to provide the most detailed portrait to date of how sequence diversity in humans is the result of an evolving interaction between sex, age, mutation type and location in the genome.