Sentences with phrase «of wild mice»

Researchers compared two species of wild mice — one promiscuous, one monogamous — to learn how genetic factors produce physical characteristics that may give one species an evolutionary edge.

Now, a new study of wild mice shows that they, too, can develop signs of domestication — white fur patches and short snouts — with hardly any human influence.

Not exact matches

Topical application of capsaicin on the dorsal skin of 7,12 - dimetylbenz (a) anthracene — initiated and TPA - promoted TRPV1 wild - type (WT) and TRPV1 knockout (KO) mice induced more and larger skin tumors in TRPV1 / KO mice, suggesting a TRPV1 - independent mechanism.

Build a house for a mouse, plant flowers for a butterfly garden, and meet one of our captive wild animals up close!

The video is a kind of a political Wild Mouse ride, with a touch of Jon Stewart and a touch of Ferris Bueller.

Homozygous mice carrying a null mutation for the DARPP - 32 gene exhibited minimal levels of P - facilitated sexual receptivity when compared to their wild - type littermates.

As the mice aged, their motor performance on a rotarod test (which measures how long the mouse can remain on a rotating rod) became impaired and the length of their strides were significantly shorter than the wild type control mice.

Researchers aware of this reality have now shown that transplanting gut bacteria from wild mice into «clean» lab mice has made those rodents less likely to die from the flu or develop cancer.

Steve: My own cats, well I have two, have brought in — you know, speaking of being mousers — in the last month or so, they have brought home a mouse, a snake, we still have wild snakes in New York City folks!

The gut bacteria from the wild mice were fairly similar, but the microbiomes of the lab mice were significantly different, with fewer Bacteroidetes and Proteobacteria, for example.

Now, immunologists at the National Institute of Diabetes and Digestive and Kidney Diseases in Bethesda, Maryland, have contaminated lab mice in a different way: by giving them gut bacteria from wild mice.

They repeated the experiment for three more generations of those mice, all of which retained a stable version of the same wild microbiome.

The study compared intestinal wound healing in two groups of mice: 1) typical mice (wild type) found in nature and 2) mice genetically deficient in the healing factor IL - 10, specifically in macrophages, which impairs their ability to have normal wound repair.

Cats, wild dogs, foxes, birds - of - prey, snakes and even certain kinds of insects have been known to prey heavily upon mice.

CELLS GONE WILD Turning off the gene Apc in mouse intestinal cells in a culture dish spurs out - of - control cell growth (left panel, pink).

At about 24 weeks, however, seventy percent of them developed spontaneous colitis, while none of the wild - type mice did.

Looking further into the intestinal crypts of both the transgenic and wild - type mice, the research team made what they consider a surprising finding: Not only was HMGA1 causing the stem cells themselves to self - renew or proliferate more rapidly in the transgenic animals, but it was also increasing the number of Paneth cells, a type of niche cell known to support intestinal stem cells.

What surprised us most was that the virus replicated in the vagina of wild - type mice with intact interferon response,» said Iwasaki.

Mice with two copies of this mutation (one on each chromosome) are white; those with just one copy are significantly lighter than wild - type mMice with two copies of this mutation (one on each chromosome) are white; those with just one copy are significantly lighter than wild - type micemice.

More inflammatory - type T cells and less tolerant - type T cells were found in the colon of mice without gp96 as compared to wild - type mice.

Several years ago, while creating a genetically engineered mouse that expresses high levels of the mouse HMGA1 gene to investigate its role in leukemia, Resar and her colleagues made the chance finding that the intestines of these animals were much larger and heavier than those of «wild - type» animals (or control mice that were not genetically modified).

To explore these questions Akiko Iwasaki, professor of immunobiology and investigator of the Howard Hughes Medical Institute, and her co-authors observed replication of the Zika virus in the vaginal tissue of control, wild - type mice (genetically unmodified mice) and mice lacking genes that regulate immune system proteins known as type I interferons.

Gough Island might have been largely uninhabited by humans, but 50 years later, residents of nearby islands raised questions about the unusually vicious mice that now roam the island (50 per cent heavier than wild mice anywhere in the world) and devastate the bird population.

Probing the link between adiponectin deficiency and metabolic disorders like diabetes and obesity, researchers from the Albert Einstein College of Medicine in New York City injected adiponectin into wild - type mice, diabetic mice, and obese diabetic mice.

But when the mice were engaged in just one type of learning, humanized and wild mice did equally well on all the tests.

«None of the neurotrophic factor manipulations influenced amyloid deposition, while they all had effects on memory function, also in wild - type mice without amyloid beta pathology,» says Susanna Kemppainen, MSc, who presented the results in her doctoral thesis.

The treatment was shown to improve long - term memory performance of APP / PS1 and wild - type mice.

This is because, on treating with the antibiotic ampicillin, no inflammation was observed in wild - type SPF mice with the induction of TH1 cells as described above, but it was caused in IL (interleukin)-10-deficient SPF mice.

Geneticist Jiří Forejt of the Czech Academy of Sciences» Institute of Molecular Genetics in Prague wasn't looking for it when he caught wild mice and bred them with lab mice to study diversity of immune system genes.

After intracerebral injection of the recombinant prion, wild - type mice developed neurological signs in ~ 130 days and reached the terminal stage of disease in ~ 150 days.

In neurons of DIXDC1 mutant mice (center) the dendrites — neural antennae that receive input from other brain cells — have fewer of the dendritic spines (white with red arrows)-- the receiving half of most synaptic inputs — compared to dendrites in wild type mice (left).

For prevention studies, they injected mouse α - syn synthetic preformed fibrils into wild - type, normal mice, as a control, and then immediately treated the mice with Syn303, one of the MAbs used (or IgG, another type of common antibody, for the control mice).

(Left) Blood smears from anemic mice indicate irregular shapes of red blood cells; (right) wild type mice indicate normal shapes of red blood cells.

Next, they showed that deer mice and oldfield mice build the same kinds of burrows in the lab as in the wild — two very different environments.

In the new work, the researchers fed two common emulsifiers, CMC and polysorbate 80, to both a genetically susceptible mouse strain and wild - type mice — those without genetic mutations that would put them at increased risk of IBD or metabolic syndrome.

The wild - type mice didn't develop colitis, but showed low - grade inflammation in their intestines and several features of metabolic syndrome: slight weight gain, increased body fat and food intake, and higher blood sugar levels, which indicate poor glucose regulation associated with diabetes.

He says, however, because they are small and easy to keep in captivity — unlike wild mice, which are notoriously difficult to maintain in cages — wall lizards would make a good model species for experiments designed to determine the effects of toxins on mortality, reproduction and growth.

The genetics of adaptation in wild mice.

The researchers followed up with two experiments: in one, they injected vasopressin into the brains of mouse parents from both of the wild species, and in the other, they genetically manipulated vasopressin neurons in the brains of house mice (Mus musculus) to excite them.

Male and female mice lacking Neuroligin - 3 modify the behavior of their wild - type littermates.

Professor Mark Viney and colleagues from the University of Bristol and the London School of Hygiene & Tropical Medicine studied the immune systems of 460 wild mice taken from 12 sites in the UK and compared them with mice bred in captivity.

(A) Histology of control diet (CD) and Western diet (WD)- fed wild - type (WT) and FXR knockout (KO) mice of both genders.

He was part of a team that found that, in mice with mitochondria from both lab and distantly related wild populations, one mitochondrial lineage tended to dominate.

However, the magnitude of these behavioral responses in knockout mice was 40 % lower than in wild - type mice.

Whereas 65 percent of new neurons in wild mice ended up in the olfactory bulb, little more than 9 percent of the mutants» neurons were able to complete the journey.

In addition, blood estrogen levels at late stages of pregnancy were found to be about two times higher in Nrk mutant mice than in wild - type mice, suggesting that Nrk is also involved in the regulation of synthesis or secretion of estrogen.

Induction of the immediate - early gene c - fos was observed after a nighttime light pulse in both wild - type and knockout mice.

Instead of using the traditional method of introducing genetic mutations into mice to create «knockout» mice — or animals with customized genes — they found they were able to find naturally occurring variants among animals in the wild.

Acute alcohol - treated FOXO3 - deficient mice developed more severe liver injury than that of wild - type mice, and this was attributed to decreased expression of autophagy - related genes.

This is a visualization of the process of transferring gut microbiota from wild mice to laboratory mice.