Sentences with phrase «of yeast genome»

During his PhD he worked on three main projects: digital scanned laser light sheet fluorescence microscopy (with Dr. Ernst Stelzer), the in toto reconstruction of zebrafish embryogenesis (with Dr. Jochen Wittbrodt), and the computational analysis of the evolution of the yeast genome architecture (with Dr. Michael Knop).

An international effort to build a carefully edited version of the yeast genome from scratch has reached a milestone by completing five more of 16 chromosomes

Not exact matches

Since the gene product of YME1 is a potent suppressor of mitochondrial DNA migration into the genome of the yeast Saccharomyces cerevisiae, Tiwari and Singh investigated the human homologue of the YME1 gene, called YME1L1.

One - third of yeast genes have counterparts in the human genome, many of which are associated with diseases, such as cancer.

Venter's team, based at the J. Craig Venter Institute in Rockville, Maryland, took the genome of one bacterium, Mycoplasma mycoides, copied it and transferred it to yeast for easier modification, and then implanted it into another bacterial species, Mycoplasma capricolum.

So far researchers have sequenced the genomes of three other organisms: two kinds of bacteria and a yeast, which is a eukaryote.

The nonredundant protein sets of flies and worms are similar in size and are only twice that of yeast, but different gene families are expanded in each genome, and the multidomain proteins and signaling pathways of the fly and worm are far more complex than those of yeast.

Bacterial genomes isolated after growth in yeast are likely to be susceptible to the restriction - modification system (s) of the recipient cell, as well as their own.

«Four centuries of domestication have also left marks in beer yeast genomes associated with traits that are useful in a brewing environment,» says Maere.

Venter's team took the genome of one bacterium, Mycoplasma mycoides, copied and modified it in yeast, and then transplanted it into another bacterial species, M. capricolum.

Bacterial genomes are notoriously difficult to modify, and using transfer into yeast as an intermediate step allows scientists to use a much wider range of genetic tools for tweaking the genome.

While in yeast, the genome was altered by using yeast genetic systems and then transplanted to produce a new strain of M. mycoides.

The CRG scientists Marina Marcet - Houben and Toni Gabaldón used advanced computational methods to study the origins of the whole genome duplication in yeast to gain a more thorough understanding of this phenomenon, which is thought to have played a key role the evolution and adaption of the species.

Rather than supporting a genome duplication event at the time when yeast evolved to have twice the number of chromosomes, their data indicated that the duplicated genes had begun to diverge long before.

With EC funding, geneticists at Trinity were able to participate in three of the early genome sequencing projects in yeast, Arabidopsis, and Bacillus subtilis.

But while the Johns Hopkins team stressed the importance of techniques developed by the Human Genome Project, Fishel pointed out that his team «built on 25 years of basic scientific research» in bacterial and yeast genetics.

Professor Gianni Liti, a senior author on the paper from the Institute for Research on Cancer and Ageing, Nice, said: «We were able to study the evolution in time by combining genome sequences of the cell populations and tracking the growth characteristics of the yeast cells.

Researchers in this study used budding yeast, creating populations of cells with more than 10 million different randomised genomes, to investigate how genetic diversity affected resistance.

Studying the budding yeast Saccharomyces cerevisiae, USC's Matthew B. Taylor and Ian M. Ehrenreich found that the effects of these genetic variants can depend on four or more other variants in an individual's genome.

Boeke's team has since edited the yeast's entire genome — streamlining it and adding molecular labels to ease future work — before farming out the synthesis of the 16 rewritten chromosomes to an international consortium of geneticists and yeast biologists.

The team that built the first synthetic yeast chromosome has added five more chromosomes to their repertoire, totalling roughly a third of the organism's genome.

As scientists race to decode genomes — not just of humans but of bacteria, yeast, chimps, dogs, whales and plants — the number of DNA sequences available for analysis has grown 40,000-fold in the past 20 years, providing unprecedented insight into billions of years of species evolution.

The results, published in the April issue of G3: Genes Genomes Genetics, a publication of the Genetics Society of America, suggest that winemakers attempting to develop improved wine yeasts will need to look to creating hybrids with more exotic strains.

Sequencing the genomes of hundreds of strains of the wine yeast S. cerevisiae has revealed little genetic diversity and high levels of inbreeding.

This past year he reached a major milestone, using the machinery of yeast to manufacture a genome from scratch.

«They are going strong,» says biologist Jef Boeke of New York University, who helped lead the research as part of the Synthetic Yeast 2.0 project — an effort to build a synthetic genome for yeast that would give scientists nearly complete control oYeast 2.0 project — an effort to build a synthetic genome for yeast that would give scientists nearly complete control oyeast that would give scientists nearly complete control of it.

In February, researchers sequencing the genomes of commercial yeast, used in most wine production, announced that inbreeding has created low genetic diversity.

The current work is just 3 percent of the way toward creating an entirely synthetic yeast genome (there are 16 chromosomes in total) and will take many more years to finish.

So far geneticists have boarded three such species on the «Ark of Genomes,» sequencing their genomes completely: Baker's yeast (Saccharomyces cerevisiae), the nematode worm Caenorhabditis elegans and the fruit fly Drosophila melanoGenomes,» sequencing their genomes completely: Baker's yeast (Saccharomyces cerevisiae), the nematode worm Caenorhabditis elegans and the fruit fly Drosophila melanogenomes completely: Baker's yeast (Saccharomyces cerevisiae), the nematode worm Caenorhabditis elegans and the fruit fly Drosophila melanogaster.

Red Eagle's dissatisfaction with research came to a head in the summer of 2002, when he quit a summer project studying the yeast genome at the Stanford Genome Technology Cgenome at the Stanford Genome Technology CGenome Technology Center.

Previous studies on budding yeast showed that whittling down the number of copies of ribosomal DNA created a genome that was very sensitive to DNA damage.

Researchers have already constructed functioning viral and bacterial genomes, and the yeast genome project, known as Sc2.0, aims to have all 16 chromosomes — roughly 10 million base pairs — assembled by the end of next year.

Last year, researchers working to synthesize the genome of a strain of yeast began to eye a much bigger prize: assembling from scratch the 3 billion base pairs of DNA that drive a human cell.

Our genome contains counterparts to one - third of yeast genes.

Ordering DNA from commercial outfits has become as easy as ordering pizza, according to Voigt, who projects that in upcoming decades scientists will be able to whip up much larger segments of DNA: synthetic genomes for yeast, animals — perhaps even humans.

With support from the High Performance Biological Computing Group at Illinois, Zhao, Si and their colleagues analyzed the modified genomes of their most promising yeast strains.

The group took the first step toward their goal of a novel engineering strategy for yeast by creating what is known as a cDNA library: a collection of over 90 % of the genes from the genome of baker's yeast (Saccharomyces cerevisiae), arranged within a custom segment of DNA so that each gene will be, in one version, overactive within a yeast cell, and in a second version, reduced in activity.

Ever since the sequencing of the first genomes from eukaryotes — a group that includes yeast and humans — scientists have wondered why most of these creatures» DNA is devoid of genes.

With gene activity - modulating parts integrating into the genome with such high efficiency, the researchers were able to randomly generate many different strains of yeast, each with its own unique set of modifications.

But the human genome is more than 200 times as large as that of yeast and it is not clear if such a synthesis would be feasible.

Dr. Boeke is leading an international consortium that is synthesizing the genome of yeast, which consists of about 12 million base pairs.

Applications of next - generation sequencing, combined with powerful yeast genetics, now create tremendous opportunities to investigate both global contributions and specific roles of ncRNAs in genome regulation and phenotypic variation.

In addition to having its genome completely sequenced, scientists have access to strains of yeast with mutations in virtually every gene.

302 No 5651 pp 1769 - 1772 «Genes that Enhance Toxicity of a Mutant Huntington Fragment or a-synuclein in Yeast» Authors: Stephen Willingham (1), Tiago Fleming Outeiro (2), Michael J. Devit (3), Susan Lindquist (2), and Paul J. Muchowski (1)(1) Department of Pharmacology, University of Washington, Seattle, WA (2) Whitehead Institute for Biomedical Research, Cambridge, MA (3) Howard Hughs Medical Institute and Department of Genome Sciences, University of Washington, Seattle, WA

«Using a powerful combination of experimental evolution and whole - genome sequencing we determined the rate of adaptation and the types of mutations that arise in populations of yeast that are identical except for the number of copies of their genome,» says Lang.

Genome - wide genetic analysis of polyploidy in yeast.

The work consisted of performing whole - genome sequencing on 1,011 samples of yeast which yielded 1,625,809 high - quality reference - based SNPs.

The collaborative nature of the yeast community's effort was nicely summed up in the 1996 Goffeau et al. paper: «Whether they worked in large centers or small laboratories, most of the 600 or so scientists involved in sequencing the yeast genome share the feeling that the worldwide ties created by this venture are of inestimable value to the future of yeast research» and indeed this has proved true.

This change, which appears to improve yeast's chances for survival in the face of hostile environmental conditions, is an epigenetic phenomenon — a heritable alteration brought about without any change to the organism's underlying genome.

Genome sequencing, not of humans but of model organisms such as yeast and fruitfly, was in full swing by the late 1990s.