Marginal structural models to estimate the causal effect
of zidovudine on the survival of HIV - positive men
If the amount of virus in the woman's body is high or unknown near the time of delivery, doctors typically order an IV
of zidovudine, which passes across the placenta from a mom to her unborn baby.
Steve Schnittman of the NIH told a research meeting in Albuquerque that because there are now several drugs to treat HIV, studies
of zidovudine alone are «not relevant in 1993».
Not exact matches
Prevention
of mother - to - child transmission (PMTCT)
of HIV has been at the forefront
of global HIV prevention efforts since 1998, following the success
of the short - course
zidovudine and single - dose nevirapine clinical trials in reducing transmission.
less than or equal to lamivudine Acquired Immune Deficiency Syndrome Antiretroviral therapy, usually means 1 - 2 drugs, used in early studies Antiretroviral
zidovudine (also known as ZDV) Breastfeeding Baby Friendly Hospital Initiative Breastfeeding and HIV International Transmission Study Combined antiretroviral therapy Centers for Disease Control and Prevention Deoxyribonucleic Acid Exclusive Breastfeeding Enzyme Linked Immunosorbent Assay Food and Agrigulture Organization Fixed dose combination ART, e.g., lamividine, stavudine, and nevirapine Highly Active Antiretroviral Therapy, 3 or more drugs for more effective treatment used in later studies Human Immunodeficiency virus International Atomic Energy Agency Infant feeding Infant and young child feeding Lopinavir cubic millimetre Mother - to - Child Transmission of HIV Non-governmental organization Nevirapine Polymerase Chain Reaction People Living with HIV Prevention of Mother - to - Child Transmission Replacement Feeding Ritonavir Ribonucleic acid, one of the three major macromolecules (along with DNA and proteins) that are essential for all known forms of life single dose NVP United Nations Agencies Joint United Nations Programme on HIV / AIDS United Nations Population Fund United Nations Commissioner for Refugees United Nations Children's Fund U.S. Agency for International Development World Alliance for Breastfeeding Action United Nations World Food Programme World Health Assembly WHO 2010 Guidelines on HIV and infant feeding World Health Organization Zidovudine (same dr
zidovudine (also known as ZDV) Breastfeeding Baby Friendly Hospital Initiative Breastfeeding and HIV International Transmission Study Combined antiretroviral therapy Centers for Disease Control and Prevention Deoxyribonucleic Acid Exclusive Breastfeeding Enzyme Linked Immunosorbent Assay Food and Agrigulture Organization Fixed dose combination ART, e.g., lamividine, stavudine, and nevirapine Highly Active Antiretroviral Therapy, 3 or more drugs for more effective treatment used in later studies Human Immunodeficiency virus International Atomic Energy Agency Infant feeding Infant and young child feeding Lopinavir cubic millimetre Mother - to - Child Transmission
of HIV Non-governmental organization Nevirapine Polymerase Chain Reaction People Living with HIV Prevention
of Mother - to - Child Transmission Replacement Feeding Ritonavir Ribonucleic acid, one
of the three major macromolecules (along with DNA and proteins) that are essential for all known forms
of life single dose NVP United Nations Agencies Joint United Nations Programme on HIV / AIDS United Nations Population Fund United Nations Commissioner for Refugees United Nations Children's Fund U.S. Agency for International Development World Alliance for Breastfeeding Action United Nations World Food Programme World Health Assembly WHO 2010 Guidelines on HIV and infant feeding World Health Organization
Zidovudine (same dr
Zidovudine (same drug as AZT)
Scientists randomly assigned babies
of HIV - positive women to get nevirapine or nevirapine plus
zidovudine (AZT).
Early work by scientists at the NIH led to the discovery that the drug AZT (
zidovudine) slows the progression
of AIDS.
In a similar study with
zidovudine, only one
of 18 animals remained free
of infection after six months.
Like
zidovudine, ddI and ddC, the three existing antiviral drugs used to treat HIV, PMEA is a modified form
of one
of the building blocks
of DNA.
One case is a clinical trial
of the drug
Zidovudine, a medication that was 75 percent effective in preventing HIV positive mothers from transmitting the disease to their unborn children.
Once inside a T cell
of the immune system,
zidovudine relies on enzymes within the cell to attach phosphate groups to it before it is ready for action.
The trial was stopped when it showed that
zidovudine delayed the onset
of disease in the short term, and it was therefore considered unethical to continue giving people placebos.
Concorde set out to compare symptom - free people who started taking
zidovudine immediately they were diagnosed HIV - positive with people who did not start treatment until they had symptoms
of AIDS.
Concorde's organisers therefore decided to allow participants with CD4 counts below this level to switch from placebo to
zidovudine regardless
of whether they had symptoms yet.
Most American trials
of AZT (
zidovudine) were stopped early for ethical reasons, so data on the drug's long - term effects have been scarce until now.
As a result, 282
of 872 symptom - free people who had been on placebo switched to
zidovudine.
When atazanavir was used with newer drugs, such as tenofovir or emtricitabine, the risk
of birth defects remained higher, but there was no significant elevation in risk when atazanavir was used with older ARV drugs like
zidovudine or lamivudine.
The AIDS programme's successes include the Concorde trial, which showed that the drug
zidovudine (AZT) can not delay the onset
of AIDS in HIV - positive people without symptoms, or increase their life expectancy.
This is in accord with our findings demonstrating a
zidovudine - induced effect on nutritional parameters with zinc - adequate, but not zinc - deficient, subjects exhibiting a significant increase in the response
of peripheral blood lymphocytes to mitogens (Baum et al. 1991).
Benefit
of oral zinc supplementation as an adjunct to
zidovudine (AZT) therapy against opportunistic infections in AIDS.