Sentences with phrase «old female mice»

Four - to six - week - old female mice were used for tumor injections.

He is quick to add, however, that even though the old female mice with newly viable eggs were allowed to cavort with young, studly mice, they did not produce offspring.

Not exact matches

Older modified male mice metabolised sugar faster than normal mice and females, suggesting that SIRT6 might extend life by protecting against metabolic disorders such as diabetes.

When Tilly and his researchers studied mice that lacked the bax gene, they found that 24 - month - old females — the equivalent of 80 - to 100 - year - old humans — still have functioning, estrogen - producing ovaries.

The breeders were either old (12 month) or young (3 month) males, each bred with two young (3 month) female mice.

The team used only older, female mice because ADDE most commonly strikes that demographic in humans.

(A) Isolated islets from 3 - wk - old, female, Tg - hIAPP mice were cultured in presence of different concentrations of islet extracts (IE) from old Tg - hIAPP mice, with overt diabetic pathology and age - matched WT mice.

(A) Isolated islets from 3 - wk - old, female, Tg - hIAPP mice were cultured in presence of different concentrations of IAPP aggregates prepared in vitro from synthetic IAPP, as well as controls treated with other amyloidogenic proteins, including the Alzheimer's disease — associated protein Tau (the K18 fragment) and the bacterial amyloid Mcc.

We examined six experimental groups of 20 - week - old C57BL / 6J mice: (a) lean C57BL / 6J female mice, (b) lean C57BL / 6J male mice, (c) moderately obese C57BL / 6J male mice with diet - induced obesity, (d) moderately obese female B6.Cg Ay / + mice, (e) severely obese female B6.V Lepob / ob mice, and (f) severely obese male B6.V Lepob / ob mice.

A pair of 2 - month - old macrophage - deficient (FVB / NJ Csf1op / op) and control (FVB / NJ Csf1 + / +) female mice were a gift of E. Richard Stanley (Albert Einstein College of Medicine, New York, New York, USA).

8 - 10 wk old female and male mice are provided ad lib access to ethanol - or pair - fed diets up to 5 % ethanol for 10 days.

Male or female (5 - 6 wks old) wild type and genetically modified mice (as required for individual investigator's protocols) will be fed a high fat high sucrose diet (from Research Diets ranging in fat from 45 - 58 % of calories as fat, 26 - 39 % carbohydrate (sucrose) and 16 % protein or control diets (10 % fat, 73 % carbohydrate, 16.4 % protein or rodent chow) for up to 16 weeks.

Mice have a high incidence of Hodgkin's - like reticulum cell neoplasm at 18 months of age and pituitary tumors in old multiparous females.

One - month - old wild - type (n = 6) and p21 - null (n = 18) female mice were irradiated (+ IR) weekly for 4 weeks with 1.75 Gy.

As a control, irradiation of wild - type mice resulted in 100 % mortality after a period of 9 months after irradiation, when the mice were 11 months old (Fig. 3 ⇓ shows the survival curve of the females alone for the purpose of simplifying the discussion below); and mortality was mainly attributable to the development of T - cell lymphomas (Table 3) ⇓.

We tested this hypothesis with 3 — 6 - month - old male and female wild - type mice.

We examined the expression of Slc6a14 in breast tumours obtained from 4 - month - old PyMT - Tg female mice and in mammary glands obtained from age - matched wild - type female mice.

To prepare ovarian cells, ovarian tissues were isolated from 1 - day - old F2 female mice produced by interbreeding C57BL6 × CBA F1 mice.

Although body weight was not different, liver weights were significantly higher (P < 0.01) in 15 - mo - old mice derived from IVC in the presence of FCS than in control animals (Supplemental Table S2); this phenotype was transmitted to F1 and F2 males derived from F0 IVC males but was not transmitted to F1 females.

Female 7 - week old nude - beige - xid mice (NCI) were injected with MCF7 / HER2 cells (5 × 106) in the right mammary fat pad.

Female 13 and 52 weeks old tg2576 and APP / PS1 mice were investigated using SmartCube ™ (spontaneous behavior), NeuroCube ™ (Measurement of gait and motor function) and the PhenoCube ™ (social interaction, day / night activity and cognition) Systems.

CD4 + and CD8 + Teffs were prepared from spleens of 8 - and 11 - week - old female Balb / c, NOD, NOR, and C57BL / 6 mice (Jackson Laboratories, Bar Harbor, ME), as previously described (7).

► A male mouse is thought to be Tom Jones, and one older, female mouse is a vocal fan; at one point a pair of large underwear is thrown toward, and lands, on the male mouse's face.

These fish is hemafrodit protogini mouse grouper when it reaches gonads and female pairs when the old will change.