Not exact matches
«When this question came up, I said, «Well, I have no idea,»» recalls Bartke, because the
mice were always killed in the
lab's endocrinology experiments before reaching
old age.
All a team has to do is extend a
lab mouse's life beyond the current record of 4.98 years — the equivalent of a 150 - year -
old human.
Reyes
lab began by treating
old dystrophic
mice with direct injection of THI.
In a
lab at MIT her team has genetically fast - forwarded the
mice into a condition much like dementia: They have problems making new memories and retrieving
old ones.
«It's a nasty virus if you're a
mouse» but doesn't sicken humans, Steel says of this 80 - year -
old lab strain, known as PR8.
Woloschak's 1990s work on the
old Argonne
lab mouse samples provides some hope.
Using a technique called parabiosis, in which the vascular systems of two
mice are surgically connected, Villeda's
lab had previously discovered that infusing
old mice with the blood of younger
mice leads to brain rejuvenation, including improvements in learning and memory, while infusions of
old blood cause premature brain aging in young
mice.
However, removing huntingtin in
mice older than 4 months appeared to cause no neurological problems, a stark contrast to the Dragatsis
lab's work.
Her
lab's most recent work, led by HMS Instructor Cristina Aguayo - Mazzucato, started instead with very
old mice, created for another experiment, whose beta cells emitted fluorescent signals.
This is explained by another finding from the Karsenty
lab: circulating levels of osteocalcin are much higher in younger
mice than in
older mice.
C.C. Little, the inventor of the modern
lab mouse and founder of the Jackson Laboratory, had long used «the age
old enmity of woman and the Muridae» as a sales pitch for his model organism.