Sentences with phrase «old mice»

Previous studies found better muscle health and stronger healing in old mice receiving blood from a younger counterpart.

The neurons of old mice pumping young blood appeared to grow new places where they could connect with other neurons.

The technique also worked on cells from older mice, but not as well.

So experiments began, again on mice, that showed how injecting young blood into older mice had positive effects on organs, bones, tissue — pretty much every system in the body.

24 male 16 - month old mice were gathered, divided into control and experimental groups, and had all their fur shaved off.

Older mice became ill, but did not always develop infection, and they ultimately recovered.

Extra vitamin E protected older mice from a bacterial infection that commonly causes pneumonia.

The problems are many: Young blood didn't do much for old mice in other studies.

All analysis was carried out on 10 week old mice.

Old mice getting plasma from young animals performed better than those receiving plasma from other elderly mice.

This new study investigates this in old mice showing signs of age - related worsening of memory function.

A recent study carried out in mice showed that complex II activity is lower in the skin of naturally aged older mice compared to younger mice.

Previously they found that in addition to old mice benefiting from young blood, young mice exposed to old blood suffered memory declines, suggesting old blood may contain «aging» factors.

The endurance of the mice also improved, enabling them to spend an average of 57 minutes on a treadmill compared with 35 minutes for untreated old mice.

Older mice seem to benefit from such an arrangement, developing healthier organs and becoming protected from age - related disease.

Those antibodies also seemed to help the brains of older mice that had aged naturally, the team found.

In 2012, researchers reversed some of the effects of cognitive decline by pumping the blood of young mice into old mice.

Additional experiments showed that the vaccine was durable, effective for at least 6 months, and that it worked well in older mice.

The scientists drew blood from old mice, whose supply of T cells was depleted, and isolated immune cells.

Several studies in recent years have shown that treatment of old mice with PARP inhibitors or precursors to NAD + such as NMN can greatly improve health.

By injecting old mice with an enzyme that encourages the binding of acetyl groups, Fischer's team were able to flip the switch on, which improved their learning and memory performance (Science, DOI: 10.1126 / science.1186088).

I was interested to read your article on blood from umbilical cords rejuvenating old mouse brains (29 April, p 18).

Vampire stories aside, the idea of rejuvenating the body with young blood dates back to macabre 1950s experiments that stitched young and old mice together so they shared a circulatory system.

A study last year by the firm Alkahest found that injecting the blood of teenagers into old mice improved their memory, cognition and physical activity.

This is because older mice lose the capacity to excrete adequate levels of two hormones: one that stimulates egg follicles to grow and mature and another that causes the ripened egg to be released from the ovary into the reproductive tract.

The researchers extracted mammary buds, the early developing form of the mammary gland, from 14 - day - old mouse embryos, which is a critical time for mammary development in rodents, according to Speroni.

The new U-M study focused on the effects of the antibody in very young and very old mice with genetic features that mimic brittle bone disease.

Finally, we examined LTP at corticostriatal synapses in 6 - month old mice using a Hebbian protocol consisting of 4 trains of 100 Hz presynaptic stimulation paired with postsynaptic depolarization.

GREEN GLOB - LINS Spurred by a dose of misfolded proteins, a 20 - week - old mouse developed clumps of deformed proteins (green) in a cluster of cells called an islet (red) in its pancreas.

But when the activity of RbAp48 was inhibited in younger mice, Kandel's team found that they behaved like older mice in laboratory learning tasks.

But in this case, the undifferentiated stem cells, harvested from 14 - day - old mouse brains, did not simply replace neurons that had died off.

Imbalances in the composition of gut microbes in older mice cause the intestines to become leaky, allowing the release of bacterial products that trigger inflammation and impair immune function.

Plasma from old mice didn't have a strong effect when injected into young mice genetically engineered to lack VCAM1 in certain blood - brain barrier cells.

Knox is now testing whether the strategy is as effective at reactivating stem cells and regenerating damaged tissue in old mice as it is in young mice.

Because mice, like humans, lose bone as they age, the scientists also treated older mice with LLP2A - Ale.

On the other hand, in a paper recently published in the Journal of Experimental Medicine, Karsenty's team was able to show that osteocalcin is needed for the beneficial effect on cognition that occurs when older mice are given plasma from younger mice.

In 2012, Research published by Dr Sinclair of Harvard stunned researchers by showing that short term supplementation with Nicotinamide Mono - Nucleotide (NMN) reversed many aspects of aging, making the cells of old mice resemble those of much younger mice, and greatly improving their health.

Left: The gut of a mouse that received a transplant of microbes from the gut of four - day - old normal mice, and then was exposed to Salmonella, while the other received a transplant of the four - day - old mouse microbes along with added Clostridia bacteria, before being exposed to Salmonella.

When the team looked in normal old mice, they saw the same, misplaced melanocytes cells taking up the space that stem cells vacated.

We measured the abundance of 8 - OHdG in DNA (isolated from rapamycin - or vehicle - treated 26 - month - old mouse liver as well as from young control liver) using the OxiSelect Oxidative DNA Damage ELISA Kit (Cell Biolabs) according to the manufacturer's instructions.

The authors show that immune cells, specifically macrophages, from old mice increase the breakdown of noradrenaline, which is involved in fat breakdown (lipolysis) allowing fat to accumulate.

The blue - bottles buzzed about the wall, and a little old mouse picked over the rubbish among the jam pots.

Example of two 9 - year - old mouse lemurs in the Restrikal cohort.

By contrast, in older mice set the same tasks, the acetyl cap was missing and no boost in gene activity occurred during learning.

«Ovaries from reproductively old mice are fibrotic and inflamed.

The GDF11 protein commonly found in the blood of young mice (the same protein that enhanced neurogenesis in aged mice) and placed in individual older mice was thought to have the same reversal effect on hypertrophy; however, more recent research suggests another molecule besides GDF11 may be at work.