Sentences with phrase «old mice as»

Not exact matches

Old input methods such as mice and keyboards are likely going to contribute to poor experiences, said Chu Hanjin, director of content alliances and solutions for AMD's Radeon Technology Group.

(And, as with the mouse who gets stuck in that old - fashioned spring trap, it must be kind of painful.)

I love that my older children have already met and fallen in love with my old friends such as Sense & Sensibility, The Great Gatsby, Moby Dick, Of Mice and Men, The Red Badge of Courage, War and Peace, The Hound of the Baskervilles, and so many, many more.

Currently, it is Maisy's Show by Lucy Cousins — mainly because, entertaining as it is, my one - year - old twins demand I read it to them several times a day, and the charm of a tap - dancing mouse with a costume made by lemurs has worn off with over-familiarity.

As for me, when I get to that voting booth I may have to fall back on that old reliable write in favorite, Mickey Mouse.

It's probably safe to say no D.J. played Modest Mouse at the uptown event, but white hair was still a hot accessory later in the night, as the older crowd gravitated towards the velvet couches (under the taxidermic animals) while younger bunches of volunteers, filmmakers, and tech consultants crowded the bars and would - be dance floor.

The scenario of hapless city slickers gamely trying to make a go of living in the country is an old classic, from Aesop's fable «The Town Mouse and the Country Mouse» and Shakespeare's As You Like It to Kaufman and Hart's 1940 play George Washington Slept Here and the»60s TV sitcom Green Acres.

In 2014, highly publicized work in the laboratories of Villeda and Tony Wyss - Coray, PhD, professor of neurology at Stanford, showed that connecting the circulatory system of a young mouse to that of an old mouse could reverse the declines in learning ability that typically emerge as mice age.

Older modified male mice metabolised sugar faster than normal mice and females, suggesting that SIRT6 might extend life by protecting against metabolic disorders such as diabetes.

By the time the mouse was 10 months old, it had also lost old plaques, as shown in these brain samples.

Current research is looking at why inhibiting certain molecules, such as mouse protein Stat3, promote muscle regeneration in mice and how to engineer orthopedic implants from stem cells to replace damaged cartilage and bone, but the results of that effort aren't expected to be necessarily aimed at the old.

As a final step, the researchers fed the CTB - MBP - containing capsules to 15 - month - old mice, the equivalent of 80 or more human years, bred to develop Alzheimer's disease.

They found that at 6 months of age, these mice had reduced capillary density and could run only half as far as normal 6 - month - old mice.

After 4 weeks of connection to young mice, the five old mice's heart tissue had thinned and softened, looking just as spry and supple as the 2 - month - olds».

They used a somewhat bizarre technique in which two mice were sutured together in such as way that they shared a circulatory system (known as parabiosis), and found old mice joined to their youthful counterparts showed changes in gene activity in a brain region called the hippocampus as well as increased neural connections and enhanced «synaptic plasticity» — a mechanism believed to underlie learning and memory in which the strength of neural connections change in response to experience.

Like all mammals, including humans, mice lose up to a third of their muscle mass and power as they get older.

A preclinical study in mice published by Cell Press January 16th in the journal Cell reveals that drugs known as histone deacetylase inhibitors (HDACis) can enhance the brain's ability to permanently replace old traumatic memories with new memories, opening promising avenues for the treatment of posttraumatic stress disorder (PTSD) and other anxiety disorders.

The scientists found that levels of a protein called GDF11 decreased in the blood of mice as they grew older.

This artificial joining of two separate animals, known as parabiosis, was a staple of physiology experiments for over a century before Irina Conboy got the idea to pair an old mouse with a young one.

«It's a nasty virus if you're a mouse» but doesn't sicken humans, Steel says of this 80 - year - old lab strain, known as PR8.

Mice lacking the receptors also retain some youthful features into old age, such as efficient oxygen metabolism (Cell, doi.org/swb).

YOUNG blood has once again shown its promise as an elixir of youth: blood from young mice helps bones of older animals heal.

The older mice were more than three times as likely to die after WNV infection.

Several years ago, researchers showed that injecting mice with a drug that stops new proteins from forming can block an old memory as it is recalled.

As these studies were being done, Malaspina asked Jay Gingrich, a psychiatrist and neuroscientist at Columbia who works with mice, whether he could look for the same effect in the offspring of older mice.

But now that we know what kinds of changes occur as these cells age, we can ask which of these changes reverse themselves when an old cell goes back to becoming a young cell» — as appeared to be the case when tissues of older mice were exposed to blood from younger mice.

By the time the mice were 3 weeks old, the researchers found that their intestines were indeed as leaky as those of mice that had been treated with a chemical that induces colitis.

When the research team gave old mice — the equivalent of 70 - to 80 - year - old humans — water containing an antioxidant known as MitoQ for four weeks, their arteries functioned as well as the arteries of mice with an equivalent human age of just 25 to 35 years.

Their younger cousins recovered fine, as did older mice with telomerase intact, but more than half of the aged, telomere - depleted mice died from the treatment.

Next, the researchers gave the drug to older mice that already showed signs of aging, such as muscle loss.

When the mice were given this antibody before or at the same time as old blood, they were protected from its harmful effects.

(A) Isolated islets from 3 - wk - old, female, Tg - hIAPP mice were cultured in presence of different concentrations of IAPP aggregates prepared in vitro from synthetic IAPP, as well as controls treated with other amyloidogenic proteins, including the Alzheimer's disease — associated protein Tau (the K18 fragment) and the bacterial amyloid Mcc.

The inoculum was obtained from old diabetic mice (fasting plasma glucose > 360 mg / dl), following a similar experimental paradigm as presented in Fig. 3.

Groups of male Tg - hIAPP mice were injected i.p. at 3 wk of age with 10 % pancreas homogenate from either 12 - mo - old, male, IAPP Tg mice bearing substantial islet amyloid aggregates (as shown in Fig. 1) or from age - matched, male, WT mice not expressing hIAPP.

(C) To evaluate impairment in glucose tolerance, the i.p. glucose tolerance test was performed in 16 - wk - old, Tg - hIAPP mice inoculated with pancreas extracts from old Tg - hIAPP (red line) as compared with Tg - hIAPP mice inoculated with PBS (black line).

The scientists infected 1 - day - old C57BL / 6 mice with Zika virus and found that they develop symptoms of neurological disease, such as unsteady gait and seizures that gradually fade over two weeks.

She's especially interested in how these change over time as the mouse grows older.

Male or female (5 - 6 wks old) wild type and genetically modified mice (as required for individual investigator's protocols) will be fed a high fat high sucrose diet (from Research Diets ranging in fat from 45 - 58 % of calories as fat, 26 - 39 % carbohydrate (sucrose) and 16 % protein or control diets (10 % fat, 73 % carbohydrate, 16.4 % protein or rodent chow) for up to 16 weeks.

Because mice, like humans, lose bone as they age, the scientists also treated older mice with LLP2A - Ale.

The researchers measured NF - κB activation in mouse brains as they aged and noted that, while the protein was barely active in the hypothalamuses of young mice, it became increasingly active as the mice got older.

So the team engineered a mouse model that gradually lost the enzyme as it grew older and then bred those mice with rodents that were engineered to develop amyloid plaques from an age of 75 days.

LPS as 2nd hit: After chronic ethanol feeding, 8 - 10 wk old mice are challenged with 0.7 μg LPS / g body weight or an equivalent volume of sterile, endotoxin - free saline (0.09 %).

As a control, irradiation of wild - type mice resulted in 100 % mortality after a period of 9 months after irradiation, when the mice were 11 months old (Fig. 3 ⇓ shows the survival curve of the females alone for the purpose of simplifying the discussion below); and mortality was mainly attributable to the development of T - cell lymphomas (Table 3) ⇓.

Mice that had been eating a ketogenic diet performed at least as well on memory tests at old age as they did at middle age, while mice eating the normal diet showed an expected age - associated declMice that had been eating a ketogenic diet performed at least as well on memory tests at old age as they did at middle age, while mice eating the normal diet showed an expected age - associated declmice eating the normal diet showed an expected age - associated decline.

I allowed the transgenic mice to lead me in many different directions, which caused problems as a new assistant professor trying to find a fundable niche, but it gave me a breadth of experience that I have tapped into as an older researcher.

The success of the treatment in older mice, which corresponded to late adulthood in humans, is particularly important, as this would be the age that would be targeted were this method ever to be used therapeutically in people.

Perhaps we should remember the experiments of Francesco Redi, Lazzaro Spallanzani, and Louis Pasteur — basic biological experiments that put to rest the theory of spontaneous generation, the belief that life had arisen spontaneously from dead matter (as, for instance, maggots from rotting meat and mice from bundles of old clothes)-- and not make the same mistake for the origin of the universe itself.

Young mice normally have an abundance of RbAp48 protein in their brains, and older mice have about half as much.

We were unable to confirm the anti-inflammatory effects of exercise in the frontal cortex using inflammatory gene expression, as the Grn − / − mice used in this study (∼ 8 months when brains were collected) were not old enough to manifest these changes, which become prominent around 1 year of age (Ahmed et al., 2010; Wils et al., 2012).

Greater running distance in the 2 - to 3 - month - old mice may partially explain these data, but the solo - housed wild - type mice used to test solo - versus group - housing (Fig. 5) ran similar distances as the young mice, yet did not show any increase in brain progranulin levels.