Not exact matches
Older mice seem to
benefit from such an arrangement, developing healthier organs and becoming protected from age - related disease.
In FTD, any
benefit of exercise on progranulin levels would need to occur in haploinsufficient individuals and at
older ages, so we considered it important to examine exercise in Grn + / −
mice at a symptomatic age.
Although we can not rule out that exercise might also increase hippocampal progranulin in 2 - to 3 - month -
old Grn + / −
mice, there is no data that an increase of this magnitude (only 10 — 15 %) restricted to hippocampus would be sufficient to produce functional improvement, and the fact that the effect is not sustained even until ∼ 4 months of age makes it highly unlikely to yield any sustained
benefit after onset of functional changes between 6 and 12 months.
The gameplay itself is
old school by using the
mouse to click everything on the screen, however, this becomes a
benefit instead of a hindrance.