Sentences with phrase «old mice increase»

Not exact matches

«In our study, the hyperglycemic mice had increased bone resorption [the breakdown and absorption of old bone], which outpaced the formation of new bone.

They used a somewhat bizarre technique in which two mice were sutured together in such as way that they shared a circulatory system (known as parabiosis), and found old mice joined to their youthful counterparts showed changes in gene activity in a brain region called the hippocampus as well as increased neural connections and enhanced «synaptic plasticity» — a mechanism believed to underlie learning and memory in which the strength of neural connections change in response to experience.

The researchers then confirmed that the number of singly paired chromosomes — also called univalents — was higher in older mouse and even human egg cells, indicating that age - related segregation errors could be tracked back to increased numbers of prematurely separated chromosome pairs.

«Older wombs linked to complications in pregnant mice: Increased risk of pregnancy complications for older mothers might be linked to poor placenta growth.&rOlder wombs linked to complications in pregnant mice: Increased risk of pregnancy complications for older mothers might be linked to poor placenta growth.&rolder mothers might be linked to poor placenta growth.»

In addition to improving endothelial function, the MitoQ treatment increased levels of nitric oxide, reduced oxidative stress and improved the health of the mitochondria in the arteries of old mice.

The research team selectively overexpressed a transcription factor, Klf9, only in older neurons in mice, which eliminated more than one - fifth of their dendritic spines, increased the number of new neurons that integrated into the hippocampus circuitry by two-fold, and activated neural stem cells.

The compound increased bone tissue in the older mice and prevented age - related bone loss.

Previous studies in the mouse BACHD model (6 month old), reported an age - dependent increase in mean firing rate of GP neurons and decrease in the mean firing rate of STN neurons in vitro (D.J. Surmeier, Northwestern Univ.) and in vivo (James Tepper, Rutgers Univ.).

Nearly a decade ago now, researchers demonstrated restoration of more youthful levels of liver function in old mice by adding a duplicate gene to increase amounts of this protein.

in young and old mice alike, small presynaptic boutons are decreased and large presynaptic boutons are increased in the fascia dentate and motor cortex with the average diameter of a presynaptic bouton increased by 40 % in the cortex

Administered in the food of 20 - month - old genetically engineered mice, at a stage when Alzheimer's pathology is advanced, J147 rescued severe memory loss, reduced soluble levels of amyloid, and increased neurotrophic factors essential for memory, after only three months of treatment.

When they looked at brains from these mice, the researchers noticed that hippocampal nerves that were between 1 and 2 months old could dramatically increase or decrease the amount of signaling chemicals they receive from neighboring nerves.

When administered in food at a stage when pathology is advanced in 20 - month - old transgenic AD mice, J147 rescued the severe loss of cognitive function, reduced soluble levels of Aβ and increased neurotrophic factors essential for memory.

MIT Technology Review: In New Anti-Aging Strategy, Clearing Out Old Cells Increases Mice Lifespan by 25 Percent

But macrophages from older mice acted differently: A-beta's presence incited a big increase in EP2 activity in these cells, resulting in amped - up output of inflammatory molecules and reduced generation of recruiting chemicals and A-beta-digesting enzymes.

The level of anxiety in APPswePS1ΔE9 mice was increased according to one report [39] whereas in 7 - month - and 12 - month - old mice of the same strain, there was a reduction in anxiety compared to wild type controls [40, 41]-RRB-.

Although exercise modestly increased progranulin in very young (2 - month - old) wild - type mice, this effect was limited to the hippocampus.

To test the hypothesis that exercise could increase brain progranulin levels in Grn + / − mice, we solo - housed 6 - month - old wild - type (Grn + / +), Grn + / −, and Grn − / − mice in standard mouse cages or cages with running wheels for 7.5 weeks.

Although we can not rule out that exercise might also increase hippocampal progranulin in 2 - to 3 - month - old Grn + / − mice, there is no data that an increase of this magnitude (only 10 — 15 %) restricted to hippocampus would be sufficient to produce functional improvement, and the fact that the effect is not sustained even until ∼ 4 months of age makes it highly unlikely to yield any sustained benefit after onset of functional changes between 6 and 12 months.

Greater running distance in the 2 - to 3 - month - old mice may partially explain these data, but the solo - housed wild - type mice used to test solo - versus group - housing (Fig. 5) ran similar distances as the young mice, yet did not show any increase in brain progranulin levels.

We found that exercise did not produce sufficient increases in progranulin mRNA or protein levels in hippocampus, frontal cortex, or thalamus of 4 - to 8 - month - old Grn + / − mice under conditions that were sufficient to increase hippocampal BDNF and activate neurogenesis.

We therefore tested 4 - to 8 - month - old Grn + / − mice with 4 weeks of wheel running (Fig. 4A), a time period that was previously reported to increase progranulin in wild - type mice (Asakura et al., 2011).

For that purpose, 21 - to 23 - month - old mice were treated with daily injections of either recombinant GDF11 (rGDF11, 0.1 mg / kg mouse body weight), a dosing regimen that increases GDF11 levels in old mice toward youthful levels (13), or phosphate - buffered saline (PBS)(vehicle) for 4 weeks, and their blood vessels were subsequently analyzed by using the volumetric assay described above.

Young blood induces vascular remodeling and increases blood flow in old mice.

al. «The telomerase activator TA - 65 elongates short telomeres and increases health span of adult / old mice without increasing cancer incidence» 2.

Gene therapy in old mice has been shown to cause to a 27 % increase in strength, along with regeneration of aging muscle.

The landmark 2013 study by Dr. Sinclair demonstrated that supplementation with NMN increased levels of NAD + and reversed age related degeneration in mice, giving older mice the muscle capacity, endurance and metabolism of much younger mice — the «equivalent of a human 60 year old becoming more like a 20 year old» (24).

At 8 months of age, both DIO and DR groups had increased hyperglycemic response during a glucose tolerance test, which was normalized in 16 - month - old mice.

One study showed an average 5 % increase in the lifespan of old mice — even though supplementation did not begin until the mice were nearing the end of their natural lifespan (24 months).11

The old wives tales about feeding a cold is true: when mice are exposed to the flu, they have an increased propensity to get ill — and stay sick longer — if they are on a low calorie diet.