Sentences with phrase «old mice with»

The study found that after injecting six - month old mice with free radicals, and then feeding them glycowithanolides extracted from ashwagandha, lipid peroxides fell substantially.

«After his experiments demonstrated improvements in memory and «rejuvenation» in the brain in old mice with young blood, we thought to try a small, phase one trial, in patients.»

Using a technique called parabiosis, in which the vascular systems of two mice are surgically connected, Villeda's lab had previously discovered that infusing old mice with the blood of younger mice leads to brain rejuvenation, including improvements in learning and memory, while infusions of old blood cause premature brain aging in young mice.

The researchers also treated old mice with 8 injections of blood plasma taken from either young mice or other geezers.

It was one of the most mind - bending scientific reports in 2014: Injecting old mice with the plasma portion of blood from young mice seemed to improve the elderly rodents» memory and ability to learn.

In 2013, researchers reported that they were able to cure hypertrophy in mice by surgically merging the circulatory systems of an older mouse with a younger mouse.

The researchers then infected younger and older mice with the bacteria Streptococcus pneumoniae, which causes so - called pneumococcal pneumonia.

«Simply by counting cell types, we immediately saw that there were more Tregs in the older mice with diabetes than any other group.»

This artificial joining of two separate animals, known as parabiosis, was a staple of physiology experiments for over a century before Irina Conboy got the idea to pair an old mouse with a young one.

Their younger cousins recovered fine, as did older mice with telomerase intact, but more than half of the aged, telomere - depleted mice died from the treatment.

Because mice, like humans, lose bone as they age, the scientists also treated older mice with LLP2A - Ale.

Further study of older mice with greater pathology will be necessary to evaluate the effects of exercise on these neuropathological features in Grn − / − mice.

Not exact matches

(And, as with the mouse who gets stuck in that old - fashioned spring trap, it must be kind of painful.)

That same weekend I did photography at a 1 year old bday party, complete with Mr. Mouse.

The happens to me a lot, especially with my little old soul: Mouse.

The team found neonatal mice with the mutations had normal - appearing skin, and the dry itchy skin of dermatitis did not develop until the mice were a few months old, the equivalent of a young adult in human years.

I love that my older children have already met and fallen in love with my old friends such as Sense & Sensibility, The Great Gatsby, Moby Dick, Of Mice and Men, The Red Badge of Courage, War and Peace, The Hound of the Baskervilles, and so many, many more.

I worked with the American Cancer Society in the late 1980s through the 1990s and lived through the «more 6 - year - olds can recognize Joe Camel than Mickey Mouse» days.

Then, I gathered her play Minnie Mouse laptop, a few of her fake phones, one of my real phones (I admit it), a couple of my old assignment notebooks (yes, she plays with these), an old Sharp Wizard device, and one of her Fisher - Price tea set tea cups, and I arranged the items on her «desk.»

Currently, it is Maisy's Show by Lucy Cousins — mainly because, entertaining as it is, my one - year - old twins demand I read it to them several times a day, and the charm of a tap - dancing mouse with a costume made by lemurs has worn off with over-familiarity.

To find out more about what underlies the cognitive decline that occurs with ageing, André Fischer of the European Neuroscience Institute in Göttingen, Germany, and colleagues analysed DNA from the brains of both young and old mice that had been set tasks involving learning and memory.

For this procedure, a smaller, younger mouse is paired with a larger, older, and more aggressive mouse.

The brains of mice engineered to develop Alzheimer's disease were riddled with these plaques, clumps of amyloid - beta protein fragments, by the time the animals were 10 months old.

Using a surgical technique called parabiosis to join the circulatory system of a young mouse with that of an old one, the researchers studied the effects of young blood on elderly cells, and vice versa.

Lemere's team looked at the effects of another complement protein in older Alzheimer's - like mice with advanced disease.

After 18 - month - old mice were treated with NMN for two months, their capillary density was restored to levels typically seen in young mice, and they experienced a 56 to 80 percent improvement in endurance.

The experiment would have been very difficult with older optogenetic devices, which are tethered to a power source and can inhibit the movement of the mice.

Additionally, the researchers report online today in Cell, old mice injected with this protein for 30 days developed younger, stronger heart tissue.

Wagers, Lee, and their colleagues used parabiosis to yoke together five 2 - year - old mice (downright ancient in mouse years) with 2 - month - old counterparts.

A preclinical study in mice published by Cell Press January 16th in the journal Cell reveals that drugs known as histone deacetylase inhibitors (HDACis) can enhance the brain's ability to permanently replace old traumatic memories with new memories, opening promising avenues for the treatment of posttraumatic stress disorder (PTSD) and other anxiety disorders.

Reyes lab began by treating old dystrophic mice with direct injection of THI.

«It's remarkable, using a lowly house mouse to monitor a major milestone in human history,» says Melinda Zeder, curator of Old World archaeology at the Smithsonian National Museum of Natural History in Washington, D.C., who wasn't involved with the study.

When the pups get older, they will learn to paddle through water mazes or bury black marbles in their bedding, giving researchers insight into how their memory and behavior compare with that of typical mice.

The lead driller, Dennis Duling, a 61 - year - old former farmer with a gray beard, sat in the control room, his calloused hand on a mouse, surveying sensor readings on a computer.

He is quick to add, however, that even though the old female mice with newly viable eggs were allowed to cavort with young, studly mice, they did not produce offspring.

The breeders were either old (12 month) or young (3 month) males, each bred with two young (3 month) female mice.

Young mice paired with old mice (left chart, two - toned) made fewer new cells in the brain's hippocampus than when paired with another young mouse (yellow).

Enter a mutant mouse strain that is afflicted at a young age with many of the diseases common to older humans.

Old mice made hundreds more new brain cells when paired with a young mouse (right chart, two - toned) than when paired with an old mouse (teaOld mice made hundreds more new brain cells when paired with a young mouse (right chart, two - toned) than when paired with an old mouse (teaold mouse (teal).

Changes in muscle repair with aging were determined by injecting the old mice and young mice (neither group exercised) with snake venom commonly used to induce muscle injury in rodent studies.

The endurance of the mice also improved, enabling them to spend an average of 57 minutes on a treadmill compared with 35 minutes for untreated old mice.

Muscle fibres in old mice injected with GDF11 doubled in size to match that of 2 - month old mice.

In the brain study, the researchers injected 15 - month - old mice — which is just over half their natural life span — with GDF11 daily for a month.

Several years ago, researchers showed that injecting mice with a drug that stops new proteins from forming can block an old memory as it is recalled.

Following transmission by mosquitoes, the early specific (also called adaptive) immune response to WNV is thought to be dominated by antibodies, and, consistent with this, the researchers found that older mice had less potent WNV - specific antibody responses during the early phase of infection.

As these studies were being done, Malaspina asked Jay Gingrich, a psychiatrist and neuroscientist at Columbia who works with mice, whether he could look for the same effect in the offspring of older mice.

And he found that the response was abnormal in mice with older fathers.

The researchers harvested satellite cells from both healthy and injured muscle tissue of young mice and from healthy tissue of old mice; extracted these cells» DNA with the histone coatings intact; and used tagged antibodies targeting the different kinds of marks to find which spots on those histones were flagged with either «stop» or «go» signals.

By the time the mice were 3 weeks old, the researchers found that their intestines were indeed as leaky as those of mice that had been treated with a chemical that induces colitis.

With wavy channels that almost resemble a school of rainbow - colored fish, this microscopic image shows molecular signs of insulation forming on the sciatic nerve of a 14 - day old mouse.