Sentences with phrase «old mouse brains»

I was interested to read your article on blood from umbilical cords rejuvenating old mouse brains (29 April, p 18).

But in this case, the undifferentiated stem cells, harvested from 14 - day - old mouse brains, did not simply replace neurons that had died off.

Not exact matches

These mice performed better than their normal counterparts on learning tests well into old age, and their brains did not exhibit the decline in neurogenesis typically seen in aged mice.

To find out more about what underlies the cognitive decline that occurs with ageing, André Fischer of the European Neuroscience Institute in Göttingen, Germany, and colleagues analysed DNA from the brains of both young and old mice that had been set tasks involving learning and memory.

By the time the mouse was 10 months old, it had also lost old plaques, as shown in these brain samples.

But the brains of 10 - month - old Alzheimer's mice that had a severely reduced amount of an enzyme called BACE1 were essentially clear of new and old plaques.

The researchers studied mice engineered to develop plaques in their brains when the animals are about 10 weeks old.

The brains of mice engineered to develop Alzheimer's disease were riddled with these plaques, clumps of amyloid - beta protein fragments, by the time the animals were 10 months old.

Ingredients in young blood can rejuvenate old mice's bodies and brains.

Eggen and his collaborators investigated the impact of high - and low - fat diets on inflammation and microglial markers in a specific brain region — the hypothalamus — of 6 - month - old mice.

They used a somewhat bizarre technique in which two mice were sutured together in such as way that they shared a circulatory system (known as parabiosis), and found old mice joined to their youthful counterparts showed changes in gene activity in a brain region called the hippocampus as well as increased neural connections and enhanced «synaptic plasticity» — a mechanism believed to underlie learning and memory in which the strength of neural connections change in response to experience.

They examined the mice's brains at 4 months old.

A preclinical study in mice published by Cell Press January 16th in the journal Cell reveals that drugs known as histone deacetylase inhibitors (HDACis) can enhance the brain's ability to permanently replace old traumatic memories with new memories, opening promising avenues for the treatment of posttraumatic stress disorder (PTSD) and other anxiety disorders.

Five years ago, researchers at the Perelman School of Medicine, University of Pennsylvania, showed that the UPR is an adaptive response to stress induced by sleep deprivation and is impaired in the brains of old mice.

Young mice paired with old mice (left chart, two - toned) made fewer new cells in the brain's hippocampus than when paired with another young mouse (yellow).

Importantly, levels of total tau and tau tangles in the brains of treated 12 - month - old mice were lower than in untreated 9 - month - old mice, suggesting that the treatment not only had stopped but reversed the buildup of tau.

MISS MATCH After paw stimulation, nerve cells in the brain of a 7 - day - old mice become active (top row, left), but blood doesn't show up (bottom row, left).

Old mice made hundreds more new brain cells when paired with a young mouse (right chart, two - toned) than when paired with an old mouse (teaOld mice made hundreds more new brain cells when paired with a young mouse (right chart, two - toned) than when paired with an old mouse (teaold mouse (teal).

Those antibodies also seemed to help the brains of older mice that had aged naturally, the team found.

Plasma from old mice didn't have a strong effect when injected into young mice genetically engineered to lack VCAM1 in certain blood - brain barrier cells.

A protein in blood can repair age - related damage in the brains and muscles of old mice, returning them to a more youthful state.

When the researchers measured the amount of virus present in different tissues, they found that, in addition to more virus in their blood and spleens, the older mice had 20-fold higher virus levels in their brains — which likely causes the excess deaths.

In the brain study, the researchers injected 15 - month - old mice — which is just over half their natural life span — with GDF11 daily for a month.

Old blood can prematurely age the brains of young mice, and scientists may now be closer to understanding how.

After the final stressors were administered, the researchers gave the young mice a round of behavioral tests and then waited until the mice reached adulthood, at about 10 weeks old, to see if their different upbringings had affected their cognitive abilities or brain morphology.

Specifically, they looked at eIF2alpha phosphorylation and the regulation of protein synthesis in the mice's hippocampus region — the part of the brain responsible for the retrieval of old memories and the encoding of new ones.

Now, the first study of its kind in mice suggests that the brain may clear away that old information in the process of forming new memories.

When Yousef injected plasma from people in their late 60s into the bodies of 3 - month - old mice — about 20 years old in human terms — the mice's brains showed signs of ageing.

Young blood gave a lift to old brains and bodies — in mice, at least.

All found that old mice get better at learning and remembering when they have young blood circulating in their brains.

The researchers measured NF - κB activation in mouse brains as they aged and noted that, while the protein was barely active in the hypothalamuses of young mice, it became increasingly active as the mice got older.

The researchers used CRISPR / Cas9 gene editing, delivered by a viral vector, to snip part of a gene producing toxic protein aggregates in the brains of 9 - month old mice.

Using a technique called parabiosis, in which the vascular systems of two mice are surgically connected, Villeda's lab had previously discovered that infusing old mice with the blood of younger mice leads to brain rejuvenation, including improvements in learning and memory, while infusions of old blood cause premature brain aging in young mice.

When they looked at brains from these mice, the researchers noticed that hippocampal nerves that were between 1 and 2 months old could dramatically increase or decrease the amount of signaling chemicals they receive from neighboring nerves.

The study found that the microglia cells — the immune cells of the brain — in middle - aged mice already showed altered activity seen in microglia from older mice.

Even 9 - month - old mice (around middle age) improved after receiving the injections, suggesting that their brains could recuperate partially after half a lifetime of damage.

To do this, a group of researchers recently used genetic techniques to remove huntingtin from adult mice of different ages, then studied their brains and behavior until old age.

Young mice normally have an abundance of RbAp48 protein in their brains, and older mice have about half as much.

We were unable to confirm the anti-inflammatory effects of exercise in the frontal cortex using inflammatory gene expression, as the Grn − / − mice used in this study (∼ 8 months when brains were collected) were not old enough to manifest these changes, which become prominent around 1 year of age (Ahmed et al., 2010; Wils et al., 2012).

To test the hypothesis that exercise could increase brain progranulin levels in Grn + / − mice, we solo - housed 6 - month - old wild - type (Grn + / +), Grn + / −, and Grn − / − mice in standard mouse cages or cages with running wheels for 7.5 weeks.

Greater running distance in the 2 - to 3 - month - old mice may partially explain these data, but the solo - housed wild - type mice used to test solo - versus group - housing (Fig. 5) ran similar distances as the young mice, yet did not show any increase in brain progranulin levels.

«After his experiments demonstrated improvements in memory and «rejuvenation» in the brain in old mice with young blood, we thought to try a small, phase one trial, in patients.»

The active ingredient THC appears to restore brain function in older mice to similar levels seen in young mice.

One of Frankland's own studies in mice, for example, found that as new brain cells are formed in the hippocampus — a region of the brain associated with learning new things — those new connections overwrite old memories and make them harder to access.

In old mice, FMD cycles promoted brain growth (hippocampal neurogenesis), which would be a nice thing to have happen in humans!

«When we provided the old mice luteolin in the diet, it reduced inflammation in the brain and, at the same time, restored working memory to what was seen in young cohorts,» study researcher Rodney Johnson, a professor at the university, said in a statement.

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The feature includes some clips of «Runaway Brain», older shorts, «House of Mouse», and even the costumed Mickey Mouse at Disney's parks, as well.

The first thing that struck me in the old brain when clutching the Kone Aimo is that it's a chunky beast, the overall width, length and height putting it firmly into the category of larger mice for the larger person who has hands capable of choking lions.