Left: The gut of a mouse that received a transplant of microbes from the gut of four - day - old normal mice, and then was exposed to Salmonella, while the other received a transplant of the four - day -
old mouse microbes along with added Clostridia bacteria, before being exposed to Salmonella.
Not exact matches
Imbalances in the composition of gut
microbes in
older mice cause the intestines to become leaky, allowing the release of bacterial products that trigger inflammation and impair immune function.
Raised in a germ - free environment, and then given a transplant of gut
microbes from a four - day -
old normal
mouse, these
mouse were still able to resist Salmonella infection without any help from their immune system — but only when they had received a dose of added Clostridium first.
They found that the samples from the
older normal
mice had the most diversity of their gut
microbes, including Clostridia and Bacteroides bacteria not seen in the younger
mice that were still getting their nutrition entirely from mother's milk.
Nunez, Kim, Sakamoto and their colleagues carried out a careful series of experiments using both newborn and adult germ - free
mice, and samples of gut
microbes taken from the feces of 4 - day -
old, 12 - day -
old and 16 - day -
old normal
mice.