Olfactory tissue transcriptomes are likely to be a rich source of novel genes for three reasons.
In addition to the eye, epidermis, and forebrain, some musculature and
olfactory tissue are also derived from donor eye field.
While both eye fields and EFTF - expressing pluripotent cells generated epidermis, forebrain, and
olfactory tissue when grafted to the anterior neural plate, transplanted eye fields also formed muscle and head mesenchyme (Figure 4 and unpublished data).
In animals with an acute sense of smell, the sinuses are largely lined by
olfactory tissue.
Transcriptomic and Proteomic Profiling Revealed High Proportions of Odorant Binding and Antimicrobial Defense Proteins in
Olfactory Tissues of the House Mouse — Barbora Kuntová — Frontiers in Genetics
Supporting this is our observation that approximately one third of both OR and VR genes with interrupted ORFs are not expressed in
olfactory tissues, a bias that had been noted previously [41].
A high proportion of the most abundantly expressed genes in our datasets, including S100a5, Obp1a, Obp1b, Lcn3, Lcn4, Mup4, Mup5, Dmbt1, Bpifa1 and 5430402E10Rik, have been previously detected in
olfactory tissues using other methods [36]--[40], but a major benefit of RNAseq is that it permits novel gene discovery.
Only 11 genes are sexually dimorphic in both
olfactory tissues.
Finally, we present evidence that hundreds of novel, putatively protein - coding genes are expressed in these highly specialized
olfactory tissues, and carry out a proof - of - principle validation.
Not exact matches
But as we get older, this process slows, and the patches of nasal
tissue without any
olfactory receptors get bigger.
In actual fact, the gene varies depending on the
tissue where it is located (cerebral cortex, cerebellum,
olfactory epithelium, etc.); in particular, what varies is the point in the «string» of code at which protein synthesis starts.
Tissue at the top of the nasal passages contains both
olfactory stem cells and «
olfactory ensheathing cells», which support and guide the growth of the neurons.
At a hospital in Portugal, the unnamed woman, a US citizen, had
tissue containing
olfactory stem cells taken from her nose and implanted in her spine.
But now a new study, published in Frontiers in Physiology, has found two
olfactory receptors in human lung
tissue.
However, two types of cells in the
olfactory epithelium (specialized
tissue responsible for sense of smell), are mixed together and form a mosaic pattern despite expressing different types of cadherins.
New study has found two
olfactory receptors in human lung
tissue.»
This specificity allowed the researchers to characterize the effect of Ggamma13 deletion on the
olfactory system without interference from changes in other
tissues.
The nose is lined with sensory
tissue, the
olfactory epithelium, that contains various types of cells, all of which arise from
olfactory stem cells (green).
Focusing their search on receptors not known to respond to any odor, the researchers identified one family of genes that appeared to be expressed in
olfactory neurons but not in other
tissues.
Smell or olfaction occurs when chemicals stimulate
olfactory receptors on a relatively small patch of
tissue located high in the nasal cavity.
(B) In situ hybridization reveals Lcn16 is expressed in glandular
tissue of the VNO and (C) Lcn17 is expressed in cells within the main
olfactory epithelium.
The whole OM samples, including the main
olfactory epithelium and underlying lamina propria, non-neuronal supporting cells, glandular
tissue and blood vessels with blood [23], yielded 46.4 million (± 4.3 million) fragments on average (Table 1).
These viruses appear to directly injure the
olfactory epithelium, the
tissue that contains the smell receptor cells.