Three biopharma giants jockey for market share in
psoriatic arthritis with new data.
The play for
psoriatic arthritis indications makes sense because it would add some depth to the companies» market penetration in the psoriasis - related disease space, which already has plenty of available options.
But Novartis, Celgene, and Pfizer are now duking it in
the psoriatic arthritis space, unveiling positive clinical trial data for inflammatory drugs Cosentyx, Otezla, and Xeljanz (respectively) during the American College of Rheumatology's (ACR) annual meeting.
The company blamed slowing growth in both the psoriasis and
psoriatic arthritis markets in the U.S. due to reimbursement challenges from insurers.
One drugmaker is skipping the crowded psoriasis track altogether and going straight to
psoriatic arthritis: Pfizer, whose Xeljanz also came up big in studies presented at ACR.
Novartis this week presented data showing that patients on Cosentyx achieved long - term improvements in the signs and symptoms of
psoriatic arthritis.
Cosentyx can steadily improve the signs and symptoms of
psoriatic arthritis — including patient - reported pain — over three years, Novartis said at the American College of Rheumatology's (ACR) annual meeting.
As of early this year, they're competing in
psoriatic arthritis, too — and each drugmaker made its case this week with new data in that disease.
These are osteoarthritis (OA), rheumatoid arthritis (RA), and
psoriatic arthritis (PsA).
It couldn't have anything to do with the fact that my dad had
psoriatic arthritis, his mom had rheumatoid arthritis, and my mom's dad also had rheumatoid arthritis.
As a breastfeeding mother Christine Jones - Wollerton has personally experienced the challenges of living with psoriasis and
psoriatic arthritis.
Psoriasis and
psoriatic arthritis can also place people at risk of side effects from the long - term use of medications such as steroids and injectable medications.
3,4,5 Psoriasis and
psoriatic arthritis can affect people physically, emotionally, financially, and socially.
There are five classifications of psoriasis and five types of
psoriatic arthritis.
Twelve months later, I developed
psoriatic arthritis.
Approximately 8.5 % of psoriasis patients have
psoriatic arthritis, which is characterized by psoriasis plus inflammation of and around the joints.
The study also draws into question the biological mechanisms by which depression increases the risk for developing
psoriatic arthritis.
Meanwhile, in the private sector, Japan has also become the first nation to approve commercialization of a first - line drug for psoriasis vulgaris and
psoriatic arthritis from the Swiss pharmaceutical company Novartis.
«For many years, the rheumatology and dermatology communities have been trying to understand which patients with psoriasis go on to develop
psoriatic arthritis and how we might detect it earlier in the disease course,» explained senior investigator Cheryl Barnabe, MD, MSc, of the McCaig Institute for Bone and Joint Health and the O'Brien Institute for Public Health, Cumming School of Medicine, at the University of Calgary, Alberta, Canada.
Based on recent laboratory work demonstrating that major depressive disorder is associated with increased systemic inflammation, the team of researchers hypothesized that psoriasis patients who develop depression are at increased risk of subsequently developing
psoriatic arthritis.
A multidisciplinary team of researchers at the University of Calgary, Canada, have found that psoriasis patients who developed depression were at a 37 % greater risk of subsequently developing
psoriatic arthritis, compared with psoriasis patients who did not develop depression.
These mechanisms may include altered systemic inflammation as a consequence of depression, or even the role of lifestyle behaviors such as physical activity or nutrition, which are typically worsened by depression, and which may place an individual at risk for
psoriatic arthritis.
«The Food and Drug Administration (FDA) has announced the approval of Inflectra (infliximab - dyyb), the first biosimilar to receive approval in the U.S. for the treatment of rheumatic diseases, including rheumatoid arthritis and
psoriatic arthritis.
Ustekinumab, sold under the name Stelara, is approved by the U.S. Food and Drug Administration to treat psoriasis,
psoriatic arthritis, and Crohn's Disease.
These episodes can make the management of inflammatory arthritis, which includes rheumatoid arthritis and
psoriatic arthritis, challenging for patients and physicians.
Another complication of psoriasis is joint involvement, a condition termed
psoriatic arthritis.
They are used worldwide to treat inflammatory conditions such as rheumatoid arthritis,
psoriatic arthritis, juvenile arthritis, Crohn's colitis, ankylosing spondylitis and psoriasis.
The risk tool could also benefit people with other inflammatory rheumatic diseases that carry higher heart disease risk, such as lupus and
psoriatic arthritis.
The results of a large population study presented today at the European League Against Rheumatism Annual Congress (EULAR 2015) showed an increased risk of developing
Psoriatic Arthritis (PsA) among psoriasis patients exposed to physical trauma, particularly when the trauma involved bone and / or joints.
The results of two studies presented at the Annual European Congress of Rheumatology (EULAR) 2017 press conference revealed promising data supporting two new drug classes for the treatment of
psoriatic arthritis (PsA).
Guselkumab, a fully human monoclonal antibody targeting IL - 23, in this Phase 2 study for the treatment of PsA, was well tolerated with no unexpected safety findings in this patient population.2 Guselkumab is now being pursued in a Phase 3 development programme for
psoriatic arthritis.
Researchers led by the Arthritis Research UK Centre for Genetics and Genomics at The University of Manchester have identified genetic variants that are associated with
psoriatic arthritis (PsA) but not with psoriasis, in the largest study of PsA ever published.
The findings could, in future, lead to the identification of people with psoriasis who are at risk of developing
psoriatic arthritis.
«New effective treatments for
psoriatic arthritis patients: Promising data to support two new drug classes.»
«Although anti-TNF treatments have revolutionised the management of
psoriatic arthritis, new next - generation therapies are needed in the treatment of this disease,» he added.
Until recently opinion was divided as to whether
psoriatic arthritis was a disease in its own right, or psoriasis combined with rheumatoid arthritis.
Psoriatic arthritis (PsA) is a condition that affects approximately 10 % of those who suffer from psoriasis.
A susceptibility gene for
psoriatic arthritis maps to chromosome 16q: evidence for imprinting.
Reykjavik, ICELAND, December 13, 2002 — deCODE genetics (Nasdaq / Nasdaq Europe: DCGN) announced today that team of deCODE scientists has mapped to a small segment of chromosome 16 a gene contributing to
psoriatic arthritis.
A Susceptibility Gene for
Psoriatic Arthritis Maps to Chromosome 16q: Evidence for Imprinting American Journal of Human Genetics 2003 Jan; 72 (1): 125 - 31.
Fatigue is a frequent complaint of people with
psoriatic arthritis.
According to one recent study, people with
psoriatic arthritis had a 30 % higher incidence of hypertension when compared with people who had severe psoriasis.
If you have
psoriatic arthritis, the good news is that medication and lifestyle changes can help ease symptoms.
Some medications used to treat
psoriatic arthritis may also alleviate symptoms of depression.
I even sort of «diagnosed» a neighbor who had a sausage finger — swollen toes and fingers are common
psoriatic arthritis symptoms.
These strategies can help make living with
psoriatic arthritis more tolerable.
Up to 30 % of people with psoriasis will also have
psoriatic arthritis.
From gout to rheumatoid arthritis to
psoriatic arthritis, pinpoint the cause of your joint pain with this guide.
Psoriatic arthritis is often mistaken for rheumatoid arthritis, another chronic autoimmune disease.
The inflammation that is a hallmark of
psoriatic arthritis can damage blood vessels and increase cardiovascular risk.