Sentences with phrase «oligodendrocyte precorsors»

Soto, I., Son, J., Marsh - Armstrong, N (2008) Proliferation and Oligodendrocyte Turnover in Optic Nerves of Glaucomatous DBA / 2J Mice.

Glaucomatous optic nerve injury involves early astrocyte reactivity and late oligodendrocyte loss.

The NG2 chondroitin sulfate proteoglycan is a membrane - spanning protein expressed by several types of immature progenitor cells, including oligodendrocyte progenitors, chondroblasts, skeletal muscle myoblasts, smooth muscle cells, and pericytes.

Extensive damage to white matter (myelin - rich brain areas) characterizes Alzheimer's disease, Huntington's disease, and Parkinson's disease, pointing to myelin damage and oligodendrocyte impairment as a common path to the progression of these diseases, even though each of these diseases may have a different cause.

We show that Olig2 + oligodendrocyte precursor - like glioma cells invade by single - cell vessel co-option and preserve the blood - brain barrier (BBB).

Oligodendrocyte differentiation was induced by culturing the cells in DMEM / F12, 1 % N2, and IGF - 1 (200 ng / ml).

This is the opposite situation to that reported in the oligodendrocyte lineage, for which a greater degree of pre-transplant differentiation is associated with less effective repair [54], [55].

One of the striking differences in outcome between our studies and work on oligodendrocyte and oligodendrocyte - precursor replacement lies in the finding that differentiation of precursor cells into a specific astrocyte subtype prior to transplantation provides a much greater level of benefit than transplantation of the precursor cells themselves.

Unfortunately, myelin can be easily damaged by a variety of pathological conditions, and stresses to the brain, and oligodendrocyte vulnerability to such damage is enhanced in the aged brain and in degenerative diseases.

AST - OPC1, an oligodendrocyte progenitor cell population derived from human embryonic stem cells, has been shown in preclinical testing in animals and in vitro to have three potentially reparative functions that address the complex pathologies observed in demyelination disorders, such as spinal cord injuries, and multiple neurodegenerative diseases, including multiple sclerosis and white matter stroke.

AST - OPC1 (oligodendrocyte progenitor cells) is currently in a Phase 1 / 2a dose escalation clinical trial in spinal cord injury.

In the November issue of Nature Methods, a team led by Paul Tesar, PhD, a NYSCF — Robertson Investigator at Case Western Reserve University, published a novel method in producing oligodendrocyte cells, the cells that are damaged in myelin - related disorders such as multiple sclerosis.

A key hold - up to applying this to humans has been the inability to isolate sufficient human cells of the oligodendrocyte lineage that could be used to myelinate the CNS.

Electrical stimulation of the medullary pyramid promotes proliferation and differentiation of oligodendrocyte progenitor cells in the corticospinal tract of the adult rat.

Regulation of store - operated and voltage - operated Ca2 + channels in the proliferation and death of oligodendrocyte precursor cells by golli proteins.

Human Embryonic Stem Cell - Derived Oligodendrocyte Progenitor Cell Transplants Improve Recovery After Cervical Spinal Cord Injury.

Immunological properties of human embryonic stem cell - derived oligodendrocyte progenitor cells.

Preclinical Safety of Human Embryonic Stem Cell - Derived Oligodendrocyte Progenitors Supporting Clinical Trials In Spinal Cord Injury.

AST - OPC1 is comprised of oligodendrocyte progenitor cells manufactured from our pluripotent embryonic stem cell platform.

Modulation of Canonical Transient Receptor Potential Channel 1 in the Proliferation of Oligodendrocyte Precursor Cells by the Golli Products of the Myelin Basic Protein Gene.

At the International Society for Stem Cell Research 2017 Annual Meeting (June 14 - 17, 2017; Boston, USA), Asterias Biotherapeutics, Inc (CA, USA) will present new 9 - month efficacy and safety data from their ongoing SCiStar Phase I / IIa trial of human embryonic stem cell - derived oligodendrocyte progenitor cells.

The researchers deliver a specific gene, which hitches a ride on a harmless virus, into the livers of mice, and once in the liver that gene codes for a protein called myelin oligodendrocyte glycoprotein.

Regulation of L - type Ca + + currents and process morphology in white matter oligodendrocyte precursor cells by golli - myelin proteins.

If you are attending ISSCR 2017, you can attend the Asterias workshop, titled «Clinical Development of hESC - derived Oligodendrocyte Progenitors for the Treatment of Spinal Cord injury» on June 13, 2017 at 10:45 am.

That type of cell, an oligodendrocyte, insulates connections in the spinal cord, allowing them to conduct electricity.

Most of these trials involve stem cell — derived neural progenitor cells, which can turn into several different types of brain or spinal cord cells, or oligodendrocyte progenitor cells, which create the myelin sheaths that insulate and protect nerve cells.

Cerebral white matter injury (WMI) persistently disrupts myelin regeneration by oligodendrocyte progenitor cells (OPCs).

Ten people will receive injections into the injury site of hESC - derived oligodendrocyte progenitor cells, which stimulate the growth of new and severed nerves and recoat damaged nerves with myelin.

Previous research in rodent disease models has shown that transplanted oligodendrocyte precursor cells derived from embryonic stem cells and from human fetal brain tissue can successfully create myelin sheaths around nerve cells, sometimes leading to dramatic improvements in symptoms.

Researchers at the Stanford University School of Medicine have succeeded in transforming skin cells directly into oligodendrocyte precursor cells, the cells that wrap nerve cells in the insulating myelin sheaths that help nerve signals propagate.

Using tumor models for both astrocytoma and oligodendroglioma, which are very similar to human tumors, they could show that one and the same cell type, called oligodendrocyte precursor cells, could give rise to both tumor forms.

Most of these trials involve stem cell - derived neural progenitor cells, which can turn into several different types of brain or spinal cord cells, or oligodendrocyte progenitor cells, which create the myelin sheaths that insulate and protect nerve cells.

PDGFRα is a cell surface tyrosine kinase receptor involved in organ development and tumor progression, it is present in multiple cell types such as mesenchymal cells, neurons, astrocytes, megakaryocytes and oligodendrocyte progenitor.

Investigators (Fumitaka Sato, PhD, et al) tested resveratrol in autoimmune and viral models of MS.. In the autoimmune model, experimental autoimmune encephalomyelitis (EAE) was induced in 6 - week - old mice using myelin oligodendrocyte glycoprotein (MOG) 35 - 55 peptide.

To test the suitability of guanabenz as a potential treatment for MS, Popko and his team exposed cultured oligodendrocyte cells to interferon gamma — a molecule that increases inflammation — resulting in greatly increased myelin loss and cell death.

The larger orange shape is an oligodendrocyte.

«We experimentally depleted B cells from the brains of young mice and saw oligodendrocyte numbers drop significantly,» Tanabe adds.

Oligodendrocyte death, occurring after a spinal cord injury, activates a process called de-myelination that results first in damage to surviving neuronal connections and finally in death of the affected neurons.

«Our findings provide direct evidence that B cells reside in the mouse neonatal brain and promote both oligodendrocyte proliferation and neuron myelination.

B - 1a cells in meningeal space secrete natural antibodies, which promote the proliferation of oligodendrocyte precorsors.

Geron Corp., which earlier got permission to administer stem cell — derived oligodendrocyte progenitors to treat spinal injury, has been bogged down in delays and may not begin its trial until late next year.

Oligodendrocyte death results in immune - mediated CNS demyelination.

The reason, say researchers: the hormone stimulates production of more oligodendrocyte stem cells, leading to more oligodendrocytes and therefore more myelin.

One mature oligodendrocyte can coat about 50 axon segments with myelin.

This type of stem cell, called an oligodendrocyte progenitor cell, is found in the brain and spinal cord.

Normally, the cells Nobel used for the test would divide and give rise to a specialized type of cell in the central nervous system called an oligodendrocyte.

«There are currently no therapies which successfully reverse the damage seen in the more than 12,000 individuals who suffer a spinal cord injury each year in the United States alone,» says Dr. Richard G. Fessler, professor of neurological surgery at Rush University Medical Center and principal investigator for the Phase 1 clinical trial involving AST - OPC1 (oligodendrocyte progenitor cells).

Neural stem cells differentiate into three different cell types: neurons (purple), oligodendrocytes (red), which produce axon insulation, and astrocytes (green), which also support neurons.

It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.

Drosha degrades the messenger RNA for NFIB in the adult hippocampal stem cells and prevents the expression of this transcription factor which is necessary for the differentiation of oligodendrocytes and thus blocks their development and therefore biases differentiation towards neurons.