Sentences with phrase «oligodendrocytes from»

Dr. Keristead created oligodendrocytes from hESCs, and showed that an injection of these cells into rats with spinal cord injuries could significantly improve their motor functions.

Not exact matches

Hypertension drug that protects cell from endoplasmic reticulum stress and preserves oligodendrocytes and myelin during inflammation

A third class of glia, known as Schwann cells and oligodendrocytes, form insulating sleeves around neurons to keep their electric signals from diffusing.

Finally, they demonstrated that zebrafish OPCs differentiate into mature oligodendrocytes when cultured together with human motor neurons, differentiated from induced pluripotent stem cells.

«We experimentally depleted B cells from the brains of young mice and saw oligodendrocyte numbers drop significantly,» Tanabe adds.

RIPK1, the researchers found, inflicts damage by directly attacking the body's myelin production plants — nerve cells known as oligodendrocytes, which secrete the soft substance, rich in fat and protein that wraps around axons to support their function and shield them from damage.

Previous research in rodent disease models has shown that transplanted oligodendrocyte precursor cells derived from embryonic stem cells and from human fetal brain tissue can successfully create myelin sheaths around nerve cells, sometimes leading to dramatic improvements in symptoms.

At the International Society for Stem Cell Research 2017 Annual Meeting (June 14 - 17, 2017; Boston, USA), Asterias Biotherapeutics, Inc (CA, USA) will present new 9 - month efficacy and safety data from their ongoing SCiStar Phase I / IIa trial of human embryonic stem cell - derived oligodendrocyte progenitor cells.

AST - OPC1 is comprised of oligodendrocyte progenitor cells manufactured from our pluripotent embryonic stem cell platform.

Following a spinal cord injury, oligodendrocytes break down and die, preventing axons from receiving the myelin they need to send signals.

AST - OPC1, an oligodendrocyte progenitor cell population derived from human embryonic stem cells, has been shown in preclinical testing in animals and in vitro to have three potentially reparative functions that address the complex pathologies observed in demyelination disorders, such as spinal cord injuries, and multiple neurodegenerative diseases, including multiple sclerosis and white matter stroke.

Starting with transplants of human oligodendrocytes in the late 1980s [40], and more recently with populations of human oligodendrocyte progenitor cells isolated from the developing or adult CNS, or from human embryonic stem cells, it has been possible to generate extensive myelination upon transplantation into spinal cord injury or into congenital mouse models of hypomyelination [41]--[48].

My laboratory studies the molecular mechanisms underlying the enhanced vulnerability of oligodendrocytes in neurodegenerative diseases such as Alzheimer's, including the age - related impairment of oligodendrocyte regeneration from glial progenitors.

Neural stem cells from the central nervous system give rise to neurons and the myelin - producing and support cells, oligodendrocytes and astrocytes, respectively.

In vitro expanded stem cells from the developing retina fail to generate photoreceptors but differentiate into myelinating oligodendrocytes.

The observations that astrocytes and even non-neural cells (J Cell Sci 2004, J Lipid Res 2007) store and can release neurotransmitter amino acids in a way resembling synaptic release, and that oligodendrocytes have NMDA type glutamate receptors (Nature 2005), together with findings that glutamate and other neuroactive substances can be co-released from nerve endings (Eur J Neurosci 2003, Molec Neurosci 2004, Cereb Cortex 2009a), including at the neuromuscular junction (Neuroscience 2007b), suggest novel ways of intercellular communication and potential drug targets.