Sentences with word «oligomer»

After the five month period, researchers found that the mice had dramatically lowered levels of alpha beta - 56, a specific form of oligomer previously implicated in the promotion of Alzheimer's disease memory loss.
«We have a new brain imaging method that can detect the toxin that leads to Alzheimer's disease,» said Klein, who first identified the amyloid beta oligomer in 1998.
Consistent with this, AFF 1 immunotherapy reduced the accumulation of AS neuropathology in neuronal bodies and neuropil at the cardinal sites for this LBD model (neocortex and hippocampus), and reduced the levels of AS dimers as well as oligomers in brain homogenates, while having no significant effect on monomeric AS.
However, fossil diesel fuel / biodiesel blends show a tendency to form precipitates — which can be considered as oligomers with aging.
And that sequence can form long chains called oligomers as well as fibers called fibrils.
Collective Effects in Second - Harmonic Generation from Plasmonic Oligomers, Nano Letters (2018).
In some neurodegenerative diseases like Alzheimer's, the tau protein changes into a toxic form called tau oligomers and begins clumping into neurofibrillary tangles.
Mairet - Coello G, Courchet J, Pieraut S, Courchet V, Maximov A and Polleux F. (2013) The CAMKK2 - AMPK Kinase Pathway Mediates the Synaptotoxic Effects of Abeta Oligomers through Tau Phosphorylation.
Mairet - Coello G., Courchet J., Pierault S., Courchet, V., Maximov A., Polleux F. (2013) The CAMKK2 - AMPK kinase pathway mediates the synaptotoxic effects of Aβ oligomers in vivo through Tau phosphorylation.
The antibody created at Northwestern binds to the toxic oligomers and could one day deliver therapies to the brain or help clinicians evaluate how a patient is responding to a new medication.
So the criminals choose enzymes that cut the chains into oligomers that are three or more building blocks long.
Yet, plaque formation may be considered a protective mechanism to sequester the neurotoxic soluble oligomers of amyloid β; indeed, many old people mentally sound have plaque.
This is the first time researchers have tailored one of these synthetic compounds, part of a class called PPMOs or peptide - conjugated phosphorodiamidate morpholino oligomers, to target a specific efflux pump found in bacterial cell walls, said Dr. David Greenberg, Associate Professor of Internal Medicine and Microbiology at UT Southwestern and a senior author of the study.
Moreover, a funnel - shaped pore in the Sec61 oligomer aligned with the exit of a tunnel traversing the large ribosomal subunit, strongly suggesting that both structures function together in the translocation of proteins across the endoplasmic reticulum membrane.
This new MRI probe technology is detecting something different from conventional technology: toxic amyloid beta oligomers instead of plaques, which occur at a stage of Alzheimer's when therapeutic intervention would be very late.
The CAMKK2 - AMPK kinase pathway mediates the synaptotoxic effects of Amyloid - beta oligomers through Tau phosphorylation on S262.
Importantly, we found that the inhibition of the catalytic activity of CAMKK2 or AMPK protects hippocampal neurons against the synaptotoxic effects induced by acute exposure to Aβ42 oligomers in vitro and against the loss of dendritic spines observed in the hAPPSWE,IND - expressing transgenic mouse model (J20) in vivo.
Last but not least, EP1LOGUE features a proprietary vasodilating and nitric oxide - boosting formulation of gallate - enhanced oligomers derived from grape seeds and marketed as 10x more powerful than the classic citrulline.
PS oligomer and BPA from plastic decomposition are toxic and can be metabolized, while styrene monomer is a suspected carcinogen.
Here, we used a nonlinear optical microscope equipped with doughnut - shaped polarization - structured beams to study such oligomers.
When, however, the pH value becomes acidic, the large oligomers dissociate and the protective protein is activated.
a) Plasmonic gold oligomer consisting of nanorods that are azimuthally arranged.
An alternative strategy, he noted, would be to limit the formation of trimers or other small, toxic SOD1 oligomers.
The researchers hypothesize that by binding snugly to the protein, the compounds they identified may be preventing these smaller oligomers from breaking free of the amyloid - beta fibrils, thus keeping toxicity in check.
In Ferris's lab, Hébrard conducted research on the formation of RNA oligomers — potential precursors of life — on clay minerals believed to be present on the primitive Earth.
The new process developed by the team, in collaboration with Dr Julien Poly from the Institut de Science des Matériaux de Mulhouse, France, is called «vinyl oligomer combination».
However, when temperature is then decreased, type - I collagen remains a fibrillar hydrogel, whereas CMA will disassemble into triple helices or short oligomers and return to a suspension.
The intervening sequence RNA excised from the ribosomal RNA precursor of Tetrahymena forms linear and circular oligomers when exposed to a heating - cooling treatment in vitro.
Using rotelle - shaped oligomers instead of spaghetti - shaped polymers, «in principle, we should be able to double the efficiency of getting the light out» — although that remains to be proved, Lupton says.
The actin then takes any CPEB oligomers that are around and activates them, which makes more actin and causes the formation of a self - replicating prion of the CPEB.
In future projects the scientists led by Buchner, Weinkauf and Groll hope to identify the molecular switch that triggers the dissociation of large Sip1 oligomers into the smaller ones.
Their markers light up if an additional oligomer that bridges the two halves binds to both, which only occurs when they park next door to each other on the target.
In a diseased brain, the mobile amyloid beta oligomers attack the synapses of neurons, destroying memory and ultimately resulting in neuron death.
Amyloid beta oligomers bind to neurons and are distinct from amyloid plaques.
Amyloid beta oligomers now are widely believed to be the culprit in the onset of Alzheimer's disease and subsequent memory loss.
A first improvement in the junction stability can be obtained with a mild oxidation of the porous silicon surface because of the enhancement of the DHI — surface interaction, and calculations have shown that the higher oxidation states in DHI oligomers create more favorable conditions for the efficient adhesion of eumelanin on silicon surface.
WLK is co-founder of Acumen Pharmaceuticals, an Alzheimer's biotech licensed by Northwestern University to develop antibodies against toxic Amyloid - β oligomers for Alzheimer's therapeutics.
«EPPS rescues hippocampus - dependent cognitive deficits in APP / PS1 mice by disaggregation of amyloid - ß oligomers and plaques» by Kim et al. published in Nature Communications on Tuesday 8th December.
Lecture 4: Replication - strand specific oligomer bias in bacterial genomes Coffee break Methods to Compare Microbial Genomes Lecture 5: 20 Methods to Compare Microbial Genomes
Amyloid - β 42 (Aβ42) has a strong ability to oligomerize to form diffusible oligomers as well as larger polymers called fibrils that form insoluble amyloid plaques, a major hallmark of AD.
To investigate the intracellular Aβ pathology, we have performed high - magnification quantitative co - localization / exclusion analysis, using three different monoclonal antibodies specific for Aβ: 1) McSA1, against Aβ residues 1 — 12; 2) MOAB - 2, against Aβ residues 1 — 4 and 3) Nu1, a conformation - specific antibody which recognizes Aβ oligomers [40].
The protein was hard to nail down because it tends to form different sized oligomers.
Examining the animal's blood cells closely revealed the key presence of inflammasomes, the multiprotein oligomers that are responsible for recognizing infections and activating immune inflammatory processes.
Beyond the internal interactions of the protein itself, these designed oligomers can be used to explore basic questions about how the structure of signaling molecules affects the behavior of receptors and cellular response.
Researchers in Berkeley Lab's Molecular Biophysics and Integrated Bioimaging (MBIB) Division worked with University of Washington's David Baker, who led a team to design in silico and crystallize self - assembling cyclic homo - oligomer proteins.
«Cyclic homo - oligomers play important roles in biological function,» said Sankaran.
Vaso6 ™ is a gallate - enhanced oligomer made up of dimers, trimers, tetramers and pentamers that is a powerful stimulator of nitric oxide production.
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