Sentences with phrase «oligomers in»

Importantly, we found that the inhibition of the catalytic activity of CAMKK2 or AMPK protects hippocampal neurons against the synaptotoxic effects induced by acute exposure to Aβ42 oligomers in vitro and against the loss of dendritic spines observed in the hAPPSWE,IND - expressing transgenic mouse model (J20) in vivo.

Mairet - Coello G., Courchet J., Pierault S., Courchet, V., Maximov A., Polleux F. (2013) The CAMKK2 - AMPK kinase pathway mediates the synaptotoxic effects of Aβ oligomers in vivo through Tau phosphorylation.

Consistent with this, AFF 1 immunotherapy reduced the accumulation of AS neuropathology in neuronal bodies and neuropil at the cardinal sites for this LBD model (neocortex and hippocampus), and reduced the levels of AS dimers as well as oligomers in brain homogenates, while having no significant effect on monomeric AS.

A purified yeast Sec61 complex bound to monomeric yeast ribosomes as an oligomer in a saturable fashion.

Not exact matches

According to Collins, the oligomers could be filtered and disposed of in a BPA water treatment facility.

In contrast with pH 8.5 treatment, the BPA molecules were destroyed and no oligomers were detected.

At the same time, researchers have found that much smaller protein clusters called oligomers — made of only a few copies of these proteins — can be highly toxic to motor neuron - like cells grown in the lab and thus are more likely to be the chief causes of brain - cell death in these diseases.

In Ferris's lab, Hébrard conducted research on the formation of RNA oligomers — potential precursors of life — on clay minerals believed to be present on the primitive Earth.

The new process developed by the team, in collaboration with Dr Julien Poly from the Institut de Science des Matériaux de Mulhouse, France, is called «vinyl oligomer combination».

Research by Finch's team in the mid -»90s also led to a startling discovery in Alzheimer's research: In 1998, working with neuroscientists at Northwestern University in Evanston, Illinois, the group reported that amyloid — the insoluble protein that piles up in the Alzheimer's - afflicted brain — is also highly neurotoxic when it clusters into small but soluble oligomers, dubbed ADDLin the mid -»90s also led to a startling discovery in Alzheimer's research: In 1998, working with neuroscientists at Northwestern University in Evanston, Illinois, the group reported that amyloid — the insoluble protein that piles up in the Alzheimer's - afflicted brain — is also highly neurotoxic when it clusters into small but soluble oligomers, dubbed ADDLin Alzheimer's research: In 1998, working with neuroscientists at Northwestern University in Evanston, Illinois, the group reported that amyloid — the insoluble protein that piles up in the Alzheimer's - afflicted brain — is also highly neurotoxic when it clusters into small but soluble oligomers, dubbed ADDLIn 1998, working with neuroscientists at Northwestern University in Evanston, Illinois, the group reported that amyloid — the insoluble protein that piles up in the Alzheimer's - afflicted brain — is also highly neurotoxic when it clusters into small but soluble oligomers, dubbed ADDLin Evanston, Illinois, the group reported that amyloid — the insoluble protein that piles up in the Alzheimer's - afflicted brain — is also highly neurotoxic when it clusters into small but soluble oligomers, dubbed ADDLin the Alzheimer's - afflicted brain — is also highly neurotoxic when it clusters into small but soluble oligomers, dubbed ADDLs.

The intervening sequence RNA excised from the ribosomal RNA precursor of Tetrahymena forms linear and circular oligomers when exposed to a heating - cooling treatment in vitro.

Moreover, a funnel - shaped pore in the Sec61 oligomer aligned with the exit of a tunnel traversing the large ribosomal subunit, strongly suggesting that both structures function together in the translocation of proteins across the endoplasmic reticulum membrane.

In the brains of patients with Alzheimer's, amyloid peptides aggregate to form oligomers and plaques that are thought to be responsible for the disease symptoms.

But these days most neuroscientists agree that a tiny particle form of the same protein, called an oligomer, is the primary toxin in the illness.

Traditional methods for mapping HIV genetic material use long strings of these nucleotides, called oligomers, to find and bind to complementary strands of DNA or RNA in sample tissues.

«Non-invasive imaging by MRI of amyloid beta oligomers is a giant step forward towards diagnosis of this debilitating disease in its earliest form,» said Dravid, the Abraham Harris Professor of Materials Science and Engineering at the McCormick School of Engineering and Applied Science.

Amyloid beta oligomers now are widely believed to be the culprit in the onset of Alzheimer's disease and subsequent memory loss.

The ability to detect amyloid beta oligomers, Klein said, is important for two reasons: amyloid beta oligomers are the toxins that damage neurons, and the oligomers are the first sign of trouble in the disease process, appearing before any other pathology.

To recycle the skin, the device is soaked into recycling solution, making the polymers degrade into oligomers (polymers with polymerization degree usually below 10) and monomers (small molecules that can be joined together into polymers) that are soluble in ethanol.

Summary: Many of the steps are known in using glyoxal with hydrogen peroxide to form dicarboxylic acids and chains of hydrocarbons, known as oligomers.

Collective Effects in Second - Harmonic Generation from Plasmonic Oligomers, Nano Letters (2018).

In particular, an oligomer based on a biguanide moiety, NB325, showed wide antiviral activity in several in vitro assayIn particular, an oligomer based on a biguanide moiety, NB325, showed wide antiviral activity in several in vitro assayin several in vitro assayin vitro assays.

We are interested in the role of secretory chaperones in the biochemistry and cell biology of the neuron and have shown that two small secretory chaperones can block the formation of both Abeta oligomers and fibrils in vitro and neurootoxic aggregates in cell culture models.

Lecture 4: Replication - strand specific oligomer bias in bacterial genomes Coffee break Methods to Compare Microbial Genomes Lecture 5: 20 Methods to Compare Microbial Genomes

Small poisonous Aβ assemblies, called oligomers, bind strongly to vulnerable neurons in the brain, but in the presence of collagen VI, this binding was blocked.

Cyclic proteins that assemble from multiple identical subunits (homo - oligomers) play key roles in many biological processes, including cell signaling and enzymatic catalysis and protein function.

«Cyclic homo - oligomers play important roles in biological function,» said Sankaran.

In a recent study, researchers at Tel Aviv University found that potent extracts from cinnamon bark inhibit the toxic amyloid polypeptide oligomers and fibrils that have been found in people with age - related cognitive issueIn a recent study, researchers at Tel Aviv University found that potent extracts from cinnamon bark inhibit the toxic amyloid polypeptide oligomers and fibrils that have been found in people with age - related cognitive issuein people with age - related cognitive issues.

Low levels of BPA and PS oligomer have been proven to cause hormone disruption in animals.

This devastating form of dementia is characterized by the accumulation of beta - protein clusters in the brain known as oligomers.