Sentences with phrase «on animal models of disease»

Workshop on Animal models of Disease, focused mainly on Rheumatoid Arthritis and other chronic inflammatory diseases.

Research on Huntington's has thus far relied heavily on animal models of the disease, and has left many key questions unanswered.

Not exact matches

The Dr Hadwen Trust for Humane Research claims that «in some instances, reliance on inaccurate animal «models» of human disease have undoubtedly delayed medical progress.»

«Chronic inflammation of the intestine is thought to be caused by abnormal interactions between gut microbes, intestinal epithelial cells and the immune system, but so far it has been impossible to determine how each of these factors contribute to the development of intestinal bowel disease,» said Hyun Jung Kim, Ph.D., former Wyss Technology Development Fellow and first author on the study, speaking about the limitations of conventional in vitro and animal models of bacterial overgrowth and inflammation of the intestines.

More work is needed to determine whether the findings on rapamycin hold true in animal models of Leigh syndrome and other neurodegenerative diseases, and to ascertain how exactly rapamycin is altering the metabolism of the cells.

«If human organs on chips can be shown to be robust and consistently recapitulate complex human organ physiology and disease phenotypes in unrelated laboratories around the world, as suggested by early proof - of - concept studies, then we will see them progressively replace one animal model at a time.

«Our work and that of our colleagues on stress and CRF have been mechanistically implicated in Alzheimer's disease, but agents that impact CRF signaling have not been carefully tested for therapeutic efficacy or long - term safety in animal models,» said the study's principal investigator and corresponding author Robert Rissman, PhD, assistant professor in the Department of Neurosciences and Biomarker Core Director for the Alzheimer's Disease Cooperative Study disease, but agents that impact CRF signaling have not been carefully tested for therapeutic efficacy or long - term safety in animal models,» said the study's principal investigator and corresponding author Robert Rissman, PhD, assistant professor in the Department of Neurosciences and Biomarker Core Director for the Alzheimer's Disease Cooperative Study Disease Cooperative Study (ADCS).

Such ease of use will likely encourage the use of more animal models in the study of human diseases, says Rhonda Wiler, a geneticist at biotech giant Genentech in San Francisco, California, who co-chairs the Roundtable on Science and Welfare in Laboratory Animal Use (which organized the workanimal models in the study of human diseases, says Rhonda Wiler, a geneticist at biotech giant Genentech in San Francisco, California, who co-chairs the Roundtable on Science and Welfare in Laboratory Animal Use (which organized the workAnimal Use (which organized the workshop).

The IOM committee left open the possibility that chimpanzees may be a necessary animal model to address future emerging or reemerging diseases, which raised the question of whether NIH will readdress its 17 - year - old ban on funding the breeding of chimpanzees for research.

Future work will focus on identifying cellular targets of ampulexins, and potentially generating a useful animal model for the study of Parkinson's disease treatments.

Professor Bruno D'Agostino from the University of Naples said: «For many years, my research group has been working on the role of nociceptin in the regulation of airway responsiveness in animal models, and it is very interesting translating our results into clinic area regarding asthma, a disease that is forecast to grow over the next years.»

It is also intended for post-docs and scientists already working in certain of these fields and who are interested in expanding their knowledge on the potential applications of these new techniques to their models or in neighbouring pathophysiological models of analysis of genes or diseases using genetically modified animals.

Although further refinement and testing is needed, Dr. Burgess said the new techniques have the potential to speed the production of many different types of transgenic animal models that will shed new light on human development and disease.

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His research interests are focused on the molecular genetics of the inherited myopathies and neuromuscular junction disorders and the study of animal models of these disorders as a means to understand their pathophysiology as well as to develop means to monitor disease progression and therapeutic interventions.

Over the last few years, scientists have been able to recreate accurate models of human organs by embedding living tissue onto chips, allowing them to study the effects of drugs and diseases without testing on animals or humans.

[15] AFF 1 vaccination preserved sufficient functionality to allow treated model PD mice to cling on for 19 s. Hindlimb engagement is by analogy a, particularly suggestive outcome for animal models of a disease of fine motor control impairment.

Working with Ye, postdoctoral fellow Sung - Wuk Jang identified a compound called 7,8 - dihydroxyflavone that can duplicate BDNFâ $ ™ s effects on neurons and can protect them against damage in animal models of seizure, stroke and Parkinsonâ $ ™ s disease.

To test this effect on disease, the researchers used a mouse model of MS and treated the animals with a drug that inhibits SIRT1.

This isn't the first study to associate the unhealthy Western diet with autoimmune and inflammatory disease, and it did only concentrate on animal models, but the potential long - term implications of these results are undeniably disturbing.

We intend to develop a quantitative, detailed and cohesive definition of neuronal susceptibility to degeneration in the cerebral cortex, by extending data on Alzheimer disease to other dementing disorders as well as animal models of age - related illnesses, and by defining the key neurochemical and morphological characteristics linked to relative vulnerability (or resistance to degeneration) of identified neuronal populations.

Much of what is known about the course of the disease before symptoms appear is based on animal models.

I am currently working on a variety of NIH - funded projects, including areas such as bioinformatics research portals, visualization for review of chart records, and tools for aiding the discovery of animal models of human diseases.

The work in humans is complemented by laboratory work involving cell death in Parkinson's disease, effects of stimulation on hippocampal neurogenesis and animal models of deep brain stimulation.

Multiple studies show that the catechin compounds found in green tea can have various protecting effects on neurons in test tubes and animals models, potentially lowering the risk of disease like Alzheimer's and Parkinson's.

In the mouse model of MS, experimental autoimmune encephalomyelitis (EAE), positive effects of modified fasting and ketogenic nutrition on disease onset and clinical course in animals have been observed in several studies.

Furthermore, in an animal model of Huntington's disease, prolonged survival, reduced disease - associated weight loss and improved motor function was observed in animals on an alternate - day fasting diet compared to animals fed ad libitum (49).

No desirable effect was observed in an animal model of amyotrophic lateral sclerosis (ALS), indicating that intermittent fasting has no beneficial effect on the development of this motor neuron disease (51).

«Given the long and established history of curcumin as a spice and herbal medicine, its demonstrated chemopreventive and therapeutic potential, and its pharmacological safety in model system, curcumin, the bioactive extract of curcumin, promises a great future in human clinical studies designed to prevent and / or delay age - related diseases,» explained the authors of a review on these and other animal studies involving curcumin.

However, most of the positive studies on glutamine supplementation in Crohn's disease were preliminary, in vitro or involved animal models.

On this basis, a ketogenic diet has been proposed as a collateral therapeutic approach in this disease.95 Studies by Zhao et al. 96 revealed both histological and functional improvements in an animal model of amyotrophic lateral sclerosis when a ketogenic diet was given compared with when given a control diet.

Her address, «A New Medical Research Model: Advancing Human and Animal Health Humanely,» will detail the concept of a new research model predicated on a meaningful commitment by both medical and veterinary researchers to work cooperatively together to address disease and disorders in humans and animals — evaluating genetic and environmental risk factors, sensitive diagnostic indicators and novel theraModel: Advancing Human and Animal Health Humanely,» will detail the concept of a new research model predicated on a meaningful commitment by both medical and veterinary researchers to work cooperatively together to address disease and disorders in humans and animals — evaluating genetic and environmental risk factors, sensitive diagnostic indicators and novel theramodel predicated on a meaningful commitment by both medical and veterinary researchers to work cooperatively together to address disease and disorders in humans and animals — evaluating genetic and environmental risk factors, sensitive diagnostic indicators and novel therapies.

Impact of the study on quality of care: Results may serve as a model for obtaining information critical to developing veterinary continuing education and public outreach programs for animal owners for various diseases.

Prior to using the One Health model, only 8 percent of cancer drugs tested on animals with artificial disease worked on people.

The emphasis is on developing intellectual abilities and research skills through investigations of infectious diseases of food - producing, companion, and aquatic animals, as well as animal models for human disease.

Dr. Dodds has been a member of many national and international committees on hematology, animal models of human disease, veterinary medicine and laboratory animal research.

Dr. Dodds has been a member of many committees on hematology, animal models of human disease and veterinary medicine.